CLL3/CLL8(FCR) comparison: multivariate prognostic factor analysis (Cox backward; n = 234)
| End point . | Variable . | P . | HR . | Lower CL . | Upper CL . |
|---|---|---|---|---|---|
| PFS | IGHV unfavorable | < .001 | 3.81 | 2.39 | 6.05 |
| Treatment CLL8(FCR) | .004 | 1.79 | 1.21 | 2.65 | |
| TTRT | IGHV unfavorable | < .001 | 3.88 | 2.22 | 6.77 |
| OS | IGHV unfavorable | .001 | 3.23 | 1.62 | 6.44 |
| Binet stage B | .083 | 5.85 | 0.79 | 43.1 | |
| Binet stage C | .014 | 12.62 | 1.69 | 94.42 | |
| Age (y) | .017 | 1.053 | 1.009 | 1.098 |
| End point . | Variable . | P . | HR . | Lower CL . | Upper CL . |
|---|---|---|---|---|---|
| PFS | IGHV unfavorable | < .001 | 3.81 | 2.39 | 6.05 |
| Treatment CLL8(FCR) | .004 | 1.79 | 1.21 | 2.65 | |
| TTRT | IGHV unfavorable | < .001 | 3.88 | 2.22 | 6.77 |
| OS | IGHV unfavorable | .001 | 3.23 | 1.62 | 6.44 |
| Binet stage B | .083 | 5.85 | 0.79 | 43.1 | |
| Binet stage C | .014 | 12.62 | 1.69 | 94.42 | |
| Age (y) | .017 | 1.053 | 1.009 | 1.098 |
Covariates considered for all end points were treatment CLL8(FCR) vs CLL3; FISH karyotype (11q-, +12, 13q- single, all other categories pooled); IGHV unfavorable vs favorable; Binet stage A, B, C; leukocyte count > 50/nL vs less; and age. Only covariates remaining in the final models are listed.
HR indicates hazard ratio.