Immunohistochemical staining results, cell of origin classification based on GC/non-GC algorithms, according the presence or the absence of MYC aberration
| Cases . | MYC+ . | MYC− . | P . |
|---|---|---|---|
| Parameter | n (%) | n (%) | |
| IHC | |||
| CD10 | 27 | 127 | |
| Positive | 16 (60) | 84 (66) | .0137 |
| Negative | 11 (40) | 43 (34) | |
| BCL6 | 26 | 128 | |
| Positive | 20 (77) | 88 (69) | .4065 |
| Negative | 6 (23) | 40 (31) | |
| MUM1/IRF4 | 27 | 128 | |
| Positive | 9 (33) | 62 (48) | .1523 |
| Negative | 18 (67) | 66 (52) | |
| FOXP1 (Barrans) | 27 | 128 | |
| Positive | 22 (81) | 86 (67) | .1420 |
| Negative | 5 (19) | 42 (33) | |
| BCL2 | 27 | 128 | |
| Positive | 22 (81) | 31 (76) | .5239 |
| Negative | 5 (19) | 97 (24) | |
| GC/non-GC algorithm publication | |||
| Hans et al18 | 27 | 125 | |
| GC | 17 (63) | 57 (46) | .1017 |
| Non-GC | 10 (37) | 68 (54) | |
| Muris et al19 | 27 | 126 | |
| Group 1 | 22 (82) | 80 (63) | .0719 |
| Group 2 | 5 (19) | 46 (37) | |
| Nyman et al20 | 23 | 123 | |
| ABC | 5 (22) | 30 (24) | .7846 |
| Others | 18 (78) | 93 (76) | |
| Cell of origin based on GEP | 3 | 24 | |
| GC | 3 (100) | 13 (54) | |
| ABC | 0 (0) | 11 (46) |
| Cases . | MYC+ . | MYC− . | P . |
|---|---|---|---|
| Parameter | n (%) | n (%) | |
| IHC | |||
| CD10 | 27 | 127 | |
| Positive | 16 (60) | 84 (66) | .0137 |
| Negative | 11 (40) | 43 (34) | |
| BCL6 | 26 | 128 | |
| Positive | 20 (77) | 88 (69) | .4065 |
| Negative | 6 (23) | 40 (31) | |
| MUM1/IRF4 | 27 | 128 | |
| Positive | 9 (33) | 62 (48) | .1523 |
| Negative | 18 (67) | 66 (52) | |
| FOXP1 (Barrans) | 27 | 128 | |
| Positive | 22 (81) | 86 (67) | .1420 |
| Negative | 5 (19) | 42 (33) | |
| BCL2 | 27 | 128 | |
| Positive | 22 (81) | 31 (76) | .5239 |
| Negative | 5 (19) | 97 (24) | |
| GC/non-GC algorithm publication | |||
| Hans et al18 | 27 | 125 | |
| GC | 17 (63) | 57 (46) | .1017 |
| Non-GC | 10 (37) | 68 (54) | |
| Muris et al19 | 27 | 126 | |
| Group 1 | 22 (82) | 80 (63) | .0719 |
| Group 2 | 5 (19) | 46 (37) | |
| Nyman et al20 | 23 | 123 | |
| ABC | 5 (22) | 30 (24) | .7846 |
| Others | 18 (78) | 93 (76) | |
| Cell of origin based on GEP | 3 | 24 | |
| GC | 3 (100) | 13 (54) | |
| ABC | 0 (0) | 11 (46) |
GC indicates germinal center; GEP, gene expression profiling; and ABC, activated B cell.