PFS and OS in prognostic subgroups
| Characteristics . | FCR 5-year rate, % . | FC 5-year rate, % . | HR (95% CI) . | P value . |
|---|---|---|---|---|
| PFS | ||||
| All patients (N = 817) | 46.8 | 25.5 | 0.59 (0.50-0.69) | <.001 |
| Age | ||||
| <65 years (N = 572) | 48.3 | 25.2 | 0.57 (0.47-0.70) | <.001 |
| ≥65 years (N = 245) | 43.2 | 26.1 | 0.63 (0.47-0.85) | .003 |
| Binet stage | ||||
| A (N = 40) | 60.2 | 28.9 | 0.44 (0.18-1.12) | .084 |
| B (N = 522) | 47.7 | 25.4 | 0.55 (0.46-0.68) | <.001 |
| C (N = 252) | 43.0 | 25.3 | 0.71 (0.53-0.95) | .023 |
| Sex | ||||
| Female (N = 210) | 58.8 | 33.1 | 0.58 (0.40-0.83) | .003 |
| Male (N = 607) | 42.6 | 23.0 | 0.59 (0.49-0.72) | <.001 |
| Cytogenetic abnormalities | ||||
| 17p deletion (N = 51) | 15.3 | 0.0 | 0.47 (0.25-0.90) | .023 |
| 11q deletion (N = 142) | 31.4 | 11.4 | 0.47 (0.32-0.68) | <.001 |
| Trisomy 12 (N = 61) | 61.6 | 23.7 | 0.41 (0.20-0.81) | .01 |
| Normal (N = 138) | 42.8 | 37.6 | 0.83 (0.54-1.26) | .365 |
| 13q deletion (N = 224) | 63.3 | 31.0 | 0.44 (0.31-0.62) | <.001 |
| IGHV mutational status | ||||
| UNM (N = 392) | 33.1 | 19.4 | 0.65 (0.52-0.82) | <.001 |
| MUT (N = 230) | 66.6 | 36.2 | 0.47 (0.33-0.68) | <.001 |
| NOTCH1 mutation | ||||
| Wild type (N = 560) | 48.0 | 25.3 | 0.55 (0.45-0.68) | <.001 |
| Mutated (N = 62) | 26.7 | 25.8 | 1.01 (0.57-1.78) | .974 |
| SF3B1 mutation | ||||
| Wild-type (N = 507) | 49.1 | 27.8 | 0.60 (0.48-0.74) | <.001 |
| Mutated (N = 114) | 31.3 | 14.9 | 0.53 (0.35-0.80) | .003 |
| OS | ||||
| All patients (N = 817) | 78.7 | 66.9 | 0.68 (0.54-0.89) | .001 |
| Age | ||||
| <65 years (N = 572) | 80.9 | 69.2 | 0.63 (0.47-0.84) | .002 |
| ≥65 years (N = 245) | 73.9 | 61.6 | 0.81 (0.54-1.20) | .288 |
| Binet stage | ||||
| A (N = 40) | 94.4 | 66.0 | 0.11 (0.01-0.84) | .034 |
| B (N = 522) | 82.1 | 66.8 | 0.59 (0.44-0.80) | .001 |
| C (N = 252) | 69.0 | 67.3 | 1.02 (0.68-1.53) | .918 |
| Sex | ||||
| Female (N = 210) | 81.3 | 64.5 | 0.56 (0.34-0.93) | .003 |
| Male (N = 607) | 77.8 | 67.8 | 0.71 (0.55-0.93) | <.001 |
| Cytogenetic abnormalities | ||||
| 17p deletion (N = 51) | 36.0 | 18.2 | 0.64 (0.32-1.25) | .19 |
| 11q deletion (N = 142) | 85.8 | 55.1 | 0.35 (0.20-0.61) | <.001 |
| Trisomy 12 (N = 61) | 91.5 | 77.4 | 0.54 (0.19-1.55) | .251 |
| Normal (N = 138) | 74.0 | 81.2 | 1.31 (0.73-2.35) | .370 |
| 13q deletion (N = 224) | 87.1 | 73.1 | 0.49 (0.28-0.84) | .01 |
| Characteristics . | FCR 5-year rate, % . | FC 5-year rate, % . | HR (95% CI) . | P value . |
|---|---|---|---|---|
| PFS | ||||
| All patients (N = 817) | 46.8 | 25.5 | 0.59 (0.50-0.69) | <.001 |
| Age | ||||
| <65 years (N = 572) | 48.3 | 25.2 | 0.57 (0.47-0.70) | <.001 |
| ≥65 years (N = 245) | 43.2 | 26.1 | 0.63 (0.47-0.85) | .003 |
| Binet stage | ||||
| A (N = 40) | 60.2 | 28.9 | 0.44 (0.18-1.12) | .084 |
| B (N = 522) | 47.7 | 25.4 | 0.55 (0.46-0.68) | <.001 |
| C (N = 252) | 43.0 | 25.3 | 0.71 (0.53-0.95) | .023 |
| Sex | ||||
| Female (N = 210) | 58.8 | 33.1 | 0.58 (0.40-0.83) | .003 |
| Male (N = 607) | 42.6 | 23.0 | 0.59 (0.49-0.72) | <.001 |
| Cytogenetic abnormalities | ||||
| 17p deletion (N = 51) | 15.3 | 0.0 | 0.47 (0.25-0.90) | .023 |
| 11q deletion (N = 142) | 31.4 | 11.4 | 0.47 (0.32-0.68) | <.001 |
| Trisomy 12 (N = 61) | 61.6 | 23.7 | 0.41 (0.20-0.81) | .01 |
| Normal (N = 138) | 42.8 | 37.6 | 0.83 (0.54-1.26) | .365 |
| 13q deletion (N = 224) | 63.3 | 31.0 | 0.44 (0.31-0.62) | <.001 |
| IGHV mutational status | ||||
| UNM (N = 392) | 33.1 | 19.4 | 0.65 (0.52-0.82) | <.001 |
| MUT (N = 230) | 66.6 | 36.2 | 0.47 (0.33-0.68) | <.001 |
| NOTCH1 mutation | ||||
| Wild type (N = 560) | 48.0 | 25.3 | 0.55 (0.45-0.68) | <.001 |
| Mutated (N = 62) | 26.7 | 25.8 | 1.01 (0.57-1.78) | .974 |
| SF3B1 mutation | ||||
| Wild-type (N = 507) | 49.1 | 27.8 | 0.60 (0.48-0.74) | <.001 |
| Mutated (N = 114) | 31.3 | 14.9 | 0.53 (0.35-0.80) | .003 |
| OS | ||||
| All patients (N = 817) | 78.7 | 66.9 | 0.68 (0.54-0.89) | .001 |
| Age | ||||
| <65 years (N = 572) | 80.9 | 69.2 | 0.63 (0.47-0.84) | .002 |
| ≥65 years (N = 245) | 73.9 | 61.6 | 0.81 (0.54-1.20) | .288 |
| Binet stage | ||||
| A (N = 40) | 94.4 | 66.0 | 0.11 (0.01-0.84) | .034 |
| B (N = 522) | 82.1 | 66.8 | 0.59 (0.44-0.80) | .001 |
| C (N = 252) | 69.0 | 67.3 | 1.02 (0.68-1.53) | .918 |
| Sex | ||||
| Female (N = 210) | 81.3 | 64.5 | 0.56 (0.34-0.93) | .003 |
| Male (N = 607) | 77.8 | 67.8 | 0.71 (0.55-0.93) | <.001 |
| Cytogenetic abnormalities | ||||
| 17p deletion (N = 51) | 36.0 | 18.2 | 0.64 (0.32-1.25) | .19 |
| 11q deletion (N = 142) | 85.8 | 55.1 | 0.35 (0.20-0.61) | <.001 |
| Trisomy 12 (N = 61) | 91.5 | 77.4 | 0.54 (0.19-1.55) | .251 |
| Normal (N = 138) | 74.0 | 81.2 | 1.31 (0.73-2.35) | .370 |
| 13q deletion (N = 224) | 87.1 | 73.1 | 0.49 (0.28-0.84) | .01 |