Univariate and multivariate analysis for OS and time to AML transformation in MDS patients
| . | OS (univariate analysis) . | OS (multivariate analysis) . | AML transformation (univariate analysis) . | AML transformation (multivariate analysis) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age, y (above vs below the median) | 1.9 | 1.1-3.2 | .013 | 1.7 | 0.9-3.0 | .065 | NS | |||||
| IPSS risk groups* (high vs low) | 2.2 | 1.7-2.8 | < .001 | 2.1 | 1.6-2.8 | < .001 | 2.9 | 2.1-4 | < .001 | 3.2 | 2.1-4.7 | < .001 |
| Transfusion dependence (yes vs no) | 2.9 | 1.7-5.1 | < .001 | 2.3 | 1.3-4.2 | .005 | 2.4 | 1.1-5 | .023 | 2.2 | 1-4.9 | .042 |
| ASXL1mut vs ASXL1wt | 2.0 | 1.2-3.5 | .007 | NS | 2.8 | 1.4-5.6 | .002 | NS | ||||
| RUNX1mut vs RUNX1wt | 2.0 | 1-4.1 | .044 | NS | 4.6 | 2.2-9.9 | < .001 | 3.1 | 1.3-7.4 | .009 | ||
| TP53mut vs TP53wt | 4.4 | 2.1-9.1 | < .001 | 2.0 | 1-4.7 | .041 | 3.9 | 1.5-10.2 | .006 | NS | ||
| CBLmut vs CBLwt | 2.6 | 1.1-6.0 | .027 | 4.4 | 1.7-11.6 | .002 | 4.3 | 1.7-11.3 | .003 | 4.1 | 1.4-12.4 | .01 |
| DNMT3Amut /SF3B1wt vs all other | 2.4 | 1.1-5.5 | .033 | NS | 2.7 | 1.1-7.7 | .04 | NS | ||||
| SRSF2mut /TET2wt vs all other | 2.3 | 1.1-5.1 | .031 | NS | 2.9 | 1.1-7.6 | .02 | NS | ||||
| ZRSR2mut/TET2wt vs all other | 2.2 | 1.0-4.9 | .042 | 3.3 | 1.4-7.7 | .006 | 2.4 | 0.9-6.8 | .077 | 3.6 | 2-4.2 | .026 |
| . | OS (univariate analysis) . | OS (multivariate analysis) . | AML transformation (univariate analysis) . | AML transformation (multivariate analysis) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age, y (above vs below the median) | 1.9 | 1.1-3.2 | .013 | 1.7 | 0.9-3.0 | .065 | NS | |||||
| IPSS risk groups* (high vs low) | 2.2 | 1.7-2.8 | < .001 | 2.1 | 1.6-2.8 | < .001 | 2.9 | 2.1-4 | < .001 | 3.2 | 2.1-4.7 | < .001 |
| Transfusion dependence (yes vs no) | 2.9 | 1.7-5.1 | < .001 | 2.3 | 1.3-4.2 | .005 | 2.4 | 1.1-5 | .023 | 2.2 | 1-4.9 | .042 |
| ASXL1mut vs ASXL1wt | 2.0 | 1.2-3.5 | .007 | NS | 2.8 | 1.4-5.6 | .002 | NS | ||||
| RUNX1mut vs RUNX1wt | 2.0 | 1-4.1 | .044 | NS | 4.6 | 2.2-9.9 | < .001 | 3.1 | 1.3-7.4 | .009 | ||
| TP53mut vs TP53wt | 4.4 | 2.1-9.1 | < .001 | 2.0 | 1-4.7 | .041 | 3.9 | 1.5-10.2 | .006 | NS | ||
| CBLmut vs CBLwt | 2.6 | 1.1-6.0 | .027 | 4.4 | 1.7-11.6 | .002 | 4.3 | 1.7-11.3 | .003 | 4.1 | 1.4-12.4 | .01 |
| DNMT3Amut /SF3B1wt vs all other | 2.4 | 1.1-5.5 | .033 | NS | 2.7 | 1.1-7.7 | .04 | NS | ||||
| SRSF2mut /TET2wt vs all other | 2.3 | 1.1-5.1 | .031 | NS | 2.9 | 1.1-7.6 | .02 | NS | ||||
| ZRSR2mut/TET2wt vs all other | 2.2 | 1.0-4.9 | .042 | 3.3 | 1.4-7.7 | .006 | 2.4 | 0.9-6.8 | .077 | 3.6 | 2-4.2 | .026 |
NS indicates not significant.
IPSS-low indicates IPSS-low risk or intermediate-1; and IPSS-high, IPSS-high or intermediate-2.