Inhibition of HDAC enzymes
| Enzyme . | IC50, nM . | Potency (fold) vs HDAC6 . |
|---|---|---|
| HDAC1 | 58 | 12 |
| HDAC2 | 48 | 10 |
| HDAC3 | 51 | 11 |
| HDAC4 | 7000 | 1500 |
| HDAC5 | 5000 | 1100 |
| HDAC6 | 4.7 | |
| HDAC7 | 1400 | 300 |
| HDAC8 | 100 | 21 |
| HDAC9 | > 10 000 | > 2100 |
| HDAC11 | > 10 000 | > 2100 |
| Sirtuin 1 | > 10 000 | > 2100 |
| Sirtuin 2 | > 10 000 | > 2100 |
| Enzyme . | IC50, nM . | Potency (fold) vs HDAC6 . |
|---|---|---|
| HDAC1 | 58 | 12 |
| HDAC2 | 48 | 10 |
| HDAC3 | 51 | 11 |
| HDAC4 | 7000 | 1500 |
| HDAC5 | 5000 | 1100 |
| HDAC6 | 4.7 | |
| HDAC7 | 1400 | 300 |
| HDAC8 | 100 | 21 |
| HDAC9 | > 10 000 | > 2100 |
| HDAC11 | > 10 000 | > 2100 |
| Sirtuin 1 | > 10 000 | > 2100 |
| Sirtuin 2 | > 10 000 | > 2100 |