Table 3 Multivariable survival analysis... | American Society of Hematology

Table 3

Multivariable survival analysis of the intermediate-risk group

Variable		OS				EFS
Variable		Hazard ratio	Lower	Upper	P	Hazard ratio	Lower	Upper	P
FLT3^ITD × NPM1	+ −	1.23	0.79	1.92	.37	1.54	1	2.37	.05
	−+	0.73	0.43	1.25	.25	0.7	0.42	1.17	.17
	++	1.09	0.66	1.79	.74	0.94	0.58	1.52	.81
FLT3^TKD	+	1.13	0.67	1.93	.64	0.99	0.6	1.63	.95
N-RAS	+	0.99	0.59	1.68	.99	1.28	0.79	2.08	.32
CEBPA^SM	+	0.99	0.35	2.81	.99	0.84	0.3	2.36	.75
CEBPA^DM	+	0.21	0.1	0.44	< .001	0.26	0.14	0.51	< .001
IDH1	+	1.09	0.67	1.79	.73	1.31	0.83	2.06	.25
IDH2	+	0.66	0.4	1.1	.11	0.79	0.49	1.27	.32
EVI1*	+	1.15	0.72	1.83	.56	1.3	0.83	2.04	.26
BAALC		1.43	0.43	4.72	.56	1.07	0.35	3.28	.91
CD34		5.09	1.73	15.01	< .001	4.47	1.62	12.32	< .001
MN1		0.59	0.21	1.67	.32	0.7	0.25	1.95	.49
ERG		4.13	1.01	16.86	.05	3.93	1.05	14.62	.04
ABCB1		0.84	0.32	2.22	.72	0.67	0.26	1.68	.39
BCL2		0.34	0.12	0.96	.04	0.42	0.15	1.15	.09
WT1		0.68	0.28	1.64	.39	0.66	0.29	1.53	.34
FLT3		0.75	0.28	2	.56	0.66	0.25	1.74	.41
INDO1		0.7	0.3	1.61	.4	0.69	0.32	1.51	.36

Variable		OS				EFS
Variable		Hazard ratio	Lower	Upper	P	Hazard ratio	Lower	Upper	P
FLT3^ITD × NPM1	+ −	1.23	0.79	1.92	.37	1.54	1	2.37	.05
	−+	0.73	0.43	1.25	.25	0.7	0.42	1.17	.17
	++	1.09	0.66	1.79	.74	0.94	0.58	1.52	.81
FLT3^TKD	+	1.13	0.67	1.93	.64	0.99	0.6	1.63	.95
N-RAS	+	0.99	0.59	1.68	.99	1.28	0.79	2.08	.32
CEBPA^SM	+	0.99	0.35	2.81	.99	0.84	0.3	2.36	.75
CEBPA^DM	+	0.21	0.1	0.44	< .001	0.26	0.14	0.51	< .001
IDH1	+	1.09	0.67	1.79	.73	1.31	0.83	2.06	.25
IDH2	+	0.66	0.4	1.1	.11	0.79	0.49	1.27	.32
EVI1*	+	1.15	0.72	1.83	.56	1.3	0.83	2.04	.26
BAALC		1.43	0.43	4.72	.56	1.07	0.35	3.28	.91
CD34		5.09	1.73	15.01	< .001	4.47	1.62	12.32	< .001
MN1		0.59	0.21	1.67	.32	0.7	0.25	1.95	.49
ERG		4.13	1.01	16.86	.05	3.93	1.05	14.62	.04
ABCB1		0.84	0.32	2.22	.72	0.67	0.26	1.68	.39
BCL2		0.34	0.12	0.96	.04	0.42	0.15	1.15	.09
WT1		0.68	0.28	1.64	.39	0.66	0.29	1.53	.34
FLT3		0.75	0.28	2	.56	0.66	0.25	1.74	.41
INDO1		0.7	0.3	1.61	.4	0.69	0.32	1.51	.36

Mutation present (or absent) groups denoted with (+) or (−). The reference category for binary mutation markers is mutation absent (−). The reference category for the combined aberration in FLT3^ITD and NPM1 is both mutations absent.

EVI expression categorized with the reference category EVI < 1.15.

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