Table 2 Univariable survival analysis in... | American Society of Hematology

Table 2

Univariable survival analysis in the intermediate-risk group

Variable		OS				EFS
Variable		Hazard ratio	Lower	Upper	P	Hazard ratio	Lower	Upper	P
NPM1	+	0.73	0.55	0.97	.03	0.69	0.53	0.9	.006
FLT3^ITD	+	1.41	1.06	1.86	.017	1.3	0.99	1.7	.059
FLT3^TKD	+	0.82	0.51	1.32	.418	0.74	0.47	1.16	.192
N-RAS	+	0.94	0.57	1.54	.798	1.23	0.77	1.94	.386
CEBPA^SM	+	1.01	0.38	2.72	.984	0.8	0.3	2.16	.662
CEBPA^DM	+	0.38	0.19	0.74	.004	0.45	0.25	0.81	.007
IDH1	+	0.83	0.52	1.31	.414	0.97	0.64	1.47	.877
IDH2	+	0.74	0.47	1.17	.199	0.79	0.51	1.21	.273
FLT3^ITD × NPM1	+−	1.67	1.13	2.46	.01	1.76	1.21	2.58	.003
	−+	0.63	0.42	0.94	.022	0.64	0.45	0.93	.018
	++	1.03	0.72	1.47	.875	0.9	0.64	1.27	.549
EVI1*	+	1.78	1.17	2.7	.007	2.01	1.34	3.02	< .001
BAALC		3.16	1.74	5.72	< .001	2.9	1.63	5.16	< .001
CD34		3.81	2.17	6.67	< .001	3.57	2.11	6.05	< .001
MN1		2.41	1.37	4.23	.002	2.51	1.46	4.32	< .001
ERG		3.69	1.65	8.26	.001	3.48	1.63	7.43	.001
ABCB1		0.99	0.51	1.93	.983	0.92	0.49	1.73	.798
BCL2		1.07	0.5	2.3	.861	1.19	0.57	2.46	.644
INDO1		0.65	0.32	1.36	.254	0.69	0.35	1.38	0.3

Variable		OS				EFS
Variable		Hazard ratio	Lower	Upper	P	Hazard ratio	Lower	Upper	P
NPM1	+	0.73	0.55	0.97	.03	0.69	0.53	0.9	.006
FLT3^ITD	+	1.41	1.06	1.86	.017	1.3	0.99	1.7	.059
FLT3^TKD	+	0.82	0.51	1.32	.418	0.74	0.47	1.16	.192
N-RAS	+	0.94	0.57	1.54	.798	1.23	0.77	1.94	.386
CEBPA^SM	+	1.01	0.38	2.72	.984	0.8	0.3	2.16	.662
CEBPA^DM	+	0.38	0.19	0.74	.004	0.45	0.25	0.81	.007
IDH1	+	0.83	0.52	1.31	.414	0.97	0.64	1.47	.877
IDH2	+	0.74	0.47	1.17	.199	0.79	0.51	1.21	.273
FLT3^ITD × NPM1	+−	1.67	1.13	2.46	.01	1.76	1.21	2.58	.003
	−+	0.63	0.42	0.94	.022	0.64	0.45	0.93	.018
	++	1.03	0.72	1.47	.875	0.9	0.64	1.27	.549
EVI1*	+	1.78	1.17	2.7	.007	2.01	1.34	3.02	< .001
BAALC		3.16	1.74	5.72	< .001	2.9	1.63	5.16	< .001
CD34		3.81	2.17	6.67	< .001	3.57	2.11	6.05	< .001
MN1		2.41	1.37	4.23	.002	2.51	1.46	4.32	< .001
ERG		3.69	1.65	8.26	.001	3.48	1.63	7.43	.001
ABCB1		0.99	0.51	1.93	.983	0.92	0.49	1.73	.798
BCL2		1.07	0.5	2.3	.861	1.19	0.57	2.46	.644
INDO1		0.65	0.32	1.36	.254	0.69	0.35	1.38	0.3

Mutation present (or absent) groups are denoted with (+) or (−). The reference category for all binary mutation markers is mutation absent (−). The reference category for the combined aberration in FLT3^ITD and NPM1 is both mutations absent.

EVI1 expression categorized with the reference category EVI1 < 1.15.

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