Summary of transplanted population, development of leukemia, and frequency of leukemic-initiating population
Experimental design . | No. of mice developing leukemia (latency in days) . | |||||||
---|---|---|---|---|---|---|---|---|
No. of cells transplanted . | No. of mice per group . | Bulk . | MPP . | CMP . | GMP . | GMP-L . | MEP . | B220+CD19+ . |
1 000 000 | 2 | 2 (27 ± 2) | 2 (21 ± 2) | 2 (33 ± 1) | 2(33 ± 0) | 0 | 0 | 0 |
100 000 | 4 | 4 (33 ± 1) | 4 (35 ± 1) | 4 (34 ± 0) | 4 (42 ± 2) | 0 | 0 | 0 |
10 000 | 6 | 6 (39 ± 2) | 6 (33 ± 1) | 6 (76 ± 13) | 5 (61 ± 8) | 0 | 0 | 0 |
1000 | 6 | 6 (40 ± 1) | 6 (42 ± 7) | 0 | 0 | 0 | 0 | 0 |
100 | 6 | 2 (152 + 20) | 6 (71 ± 3) | 0 | 0 | 0 | 0 | 0 |
10 | 6 | 0 | 2 (85 ± 5) | 0 | 0 | 0 | 0 | 0 |
Frequency of LIC in sorted population | 1:234 | 1:22 | 1:4,341 | 1:7,212 | NA | NA | NA |
Experimental design . | No. of mice developing leukemia (latency in days) . | |||||||
---|---|---|---|---|---|---|---|---|
No. of cells transplanted . | No. of mice per group . | Bulk . | MPP . | CMP . | GMP . | GMP-L . | MEP . | B220+CD19+ . |
1 000 000 | 2 | 2 (27 ± 2) | 2 (21 ± 2) | 2 (33 ± 1) | 2(33 ± 0) | 0 | 0 | 0 |
100 000 | 4 | 4 (33 ± 1) | 4 (35 ± 1) | 4 (34 ± 0) | 4 (42 ± 2) | 0 | 0 | 0 |
10 000 | 6 | 6 (39 ± 2) | 6 (33 ± 1) | 6 (76 ± 13) | 5 (61 ± 8) | 0 | 0 | 0 |
1000 | 6 | 6 (40 ± 1) | 6 (42 ± 7) | 0 | 0 | 0 | 0 | 0 |
100 | 6 | 2 (152 + 20) | 6 (71 ± 3) | 0 | 0 | 0 | 0 | 0 |
10 | 6 | 0 | 2 (85 ± 5) | 0 | 0 | 0 | 0 | 0 |
Frequency of LIC in sorted population | 1:234 | 1:22 | 1:4,341 | 1:7,212 | NA | NA | NA |
NA indicates not applicable.