Proportion of patients with LIC < 7, 7-14, or > 14 mg Fe/g dw at EOS (last observation carried forward) and mean actual dose categories by iron intake
| . | Iron intake during study, mg/kg/d . | ||
|---|---|---|---|
| < 0.3 (n = 83) . | 0.3-0.5 (n = 266) . | > 0.5 (n = 44) . | |
| LIC category at EOS, n (%) | |||
| < 7 mg Fe/g dw | 36 (43.4) | 120 (45.1) | 20 (45.5) |
| 7-14 mg Fe/g dw | 30 (36.1) | 77 (28.9) | 13 (29.5) |
| > 14 mg Fe/g dw | 17 (20.5) | 69 (25.9) | 11 (25.0) |
| Mean actual dose during study, n (%) | |||
| 5 to < 15 mg/kg/d | 15 (18.1) | 29 (10.9) | 2 (4.5) |
| 15 to < 25 mg/kg/d | 45 (54.2) | 145 (54.5) | 23 (52.3) |
| 25 to < 35 mg/kg/d | 23 (27.7) | 89 (33.5) | 19 (43.2) |
| ≥ 35 mg/kg/d | 0 | 3 (1.1) | 0 |
| Final actual dose during study, n (%) | |||
| 5 to < 15 mg/kg/d | 16 (19.3) | 20 (7.5) | 2 (4.5) |
| 15 to < 25 mg/kg/d | 32 (38.6) | 115 (43.2) | 11 (25.0) |
| 25 to < 35 mg/kg/d | 28 (33.7) | 93 (35.0) | 26 (59.1) |
| ≥ 35 mg/kg/d | 7 (8.4) | 38 (14.3) | 5 (11.4) |
| . | Iron intake during study, mg/kg/d . | ||
|---|---|---|---|
| < 0.3 (n = 83) . | 0.3-0.5 (n = 266) . | > 0.5 (n = 44) . | |
| LIC category at EOS, n (%) | |||
| < 7 mg Fe/g dw | 36 (43.4) | 120 (45.1) | 20 (45.5) |
| 7-14 mg Fe/g dw | 30 (36.1) | 77 (28.9) | 13 (29.5) |
| > 14 mg Fe/g dw | 17 (20.5) | 69 (25.9) | 11 (25.0) |
| Mean actual dose during study, n (%) | |||
| 5 to < 15 mg/kg/d | 15 (18.1) | 29 (10.9) | 2 (4.5) |
| 15 to < 25 mg/kg/d | 45 (54.2) | 145 (54.5) | 23 (52.3) |
| 25 to < 35 mg/kg/d | 23 (27.7) | 89 (33.5) | 19 (43.2) |
| ≥ 35 mg/kg/d | 0 | 3 (1.1) | 0 |
| Final actual dose during study, n (%) | |||
| 5 to < 15 mg/kg/d | 16 (19.3) | 20 (7.5) | 2 (4.5) |
| 15 to < 25 mg/kg/d | 32 (38.6) | 115 (43.2) | 11 (25.0) |
| 25 to < 35 mg/kg/d | 28 (33.7) | 93 (35.0) | 26 (59.1) |
| ≥ 35 mg/kg/d | 7 (8.4) | 38 (14.3) | 5 (11.4) |
Only patients with a LIC value at both start of deferasirox and EOS evaluated with the same method (either SQUID or biopsy) are included. EOS values represent the last observation carried forward after starting deferasirox, irrespective of length of deferasirox exposure.