List of down-regulated genes (HIF1α−/− LSCs vs WT LSCs)
| Symbol . | Gene name . | Relative fold change, Log2 . |
|---|---|---|
| Mcpt2 | Mast cell protease 2 | −1.63 |
| Tnfrsf9 | Tumor necrosis factor receptor superfamily, member 9 | −1.61 |
| Mcpt1 | Mast cell protease 1 | −1.57 |
| Rps25 | Ribosomal protein S25 | −1.43 |
| Mcpt4 | Mast cell protease 4 | −1.33 |
| Bnip3 | BCL2/adenovirus E1B-interacting protein 3 | −1.28 |
| Cox7c | Cytochrome c oxidase, subunit viic | −1.20 |
| Tph1 | Tryptophan hydroxylase 1 | −1.16 |
| Gzmb | Granzyme B | −1.01 |
| Bnip3 | BCL2/adenovirus E1B-interacting protein 3 | −0.95 |
| Plod2 | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | −0.94 |
| Ccr2 | Chemokine (C-C motif) receptor 2 | −0.87 |
| Slc16a3 | Solute carrier family 16 (monocarboxylic acid transporters), member 3 | −0.87 |
| Lipo1 | Lipase, member O1 | −0.87 |
| Cma1 | Chymase 1, mast cell | −0.85 |
| Dntt | Deoxynucleotidyltransferase, terminal | −0.85 |
| Xcr1 | Chemokine (C motif) receptor 1 | −0.84 |
| Hmgb1 | High mobility group box 1 | −0.83 |
| Marcks | Myristoylated alanine-rich protein kinase C substrate | −0.82 |
| Gapdh | Glyceraldehyde-3-phosphate dehydrogenase | −0.81 |
| Serpine1 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 | −0.79 |
| Gimap4 | GTPase, IMAP family member 4 | −0.77 |
| Akr1c12 | Aldo-keto reductase family 1, member C12 | −0.74 |
| Itgae | Integrin alpha E, epithelial associated | −0.70 |
| Ebf1 | Early B-cell factor 1 | −0.69 |
| Maob | Monoamine oxidase B | −0.68 |
| Tlr3 | Toll-like receptor 3 | −0.65 |
| Cd36 | CD36 antigen | −0.65 |
| Kmo | Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | −0.65 |
| Il13ra1 | Interleukin 13 receptor, alpha 1 | −0.65 |
| Stat4 | Signal transducer and activator of transcription 4 | −0.64 |
| Slamf7 | SLAM family member 7 | −0.63 |
| Il7r | Interleukin 7 receptor | −0.61 |
| Cdkn1b | Cyclin-dependent kinase inhibitor 1B | −0.60 |
| Sucnr1 | Succinate receptor 1 | −0.60 |
| Irf8 | Interferon regulatory factor 8 | −0.59 |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | −0.58 |
| Nov | Nephroblastoma overexpressed gene | −0.56 |
| Ptprg | Protein tyrosine phosphatase, receptor type, G | −0.55 |
| Socs2 | Suppressor of cytokine signaling 2 | −0.53 |
| Irf5 | Interferon regulatory factor 5 | −0.51 |
| Igfbp5 | Insulin-like growth factor–binding protein 5 | −0.50 |
| Slamf6 | SLAM family member 6 | −0.50 |
| Slc2a1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | −0.50 |
| Lef1 | Lymphoid enhancer-binding factor 1 | −0.49 |
| Cd96 | CD96 antigen | −0.49 |
| Symbol . | Gene name . | Relative fold change, Log2 . |
|---|---|---|
| Mcpt2 | Mast cell protease 2 | −1.63 |
| Tnfrsf9 | Tumor necrosis factor receptor superfamily, member 9 | −1.61 |
| Mcpt1 | Mast cell protease 1 | −1.57 |
| Rps25 | Ribosomal protein S25 | −1.43 |
| Mcpt4 | Mast cell protease 4 | −1.33 |
| Bnip3 | BCL2/adenovirus E1B-interacting protein 3 | −1.28 |
| Cox7c | Cytochrome c oxidase, subunit viic | −1.20 |
| Tph1 | Tryptophan hydroxylase 1 | −1.16 |
| Gzmb | Granzyme B | −1.01 |
| Bnip3 | BCL2/adenovirus E1B-interacting protein 3 | −0.95 |
| Plod2 | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | −0.94 |
| Ccr2 | Chemokine (C-C motif) receptor 2 | −0.87 |
| Slc16a3 | Solute carrier family 16 (monocarboxylic acid transporters), member 3 | −0.87 |
| Lipo1 | Lipase, member O1 | −0.87 |
| Cma1 | Chymase 1, mast cell | −0.85 |
| Dntt | Deoxynucleotidyltransferase, terminal | −0.85 |
| Xcr1 | Chemokine (C motif) receptor 1 | −0.84 |
| Hmgb1 | High mobility group box 1 | −0.83 |
| Marcks | Myristoylated alanine-rich protein kinase C substrate | −0.82 |
| Gapdh | Glyceraldehyde-3-phosphate dehydrogenase | −0.81 |
| Serpine1 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 | −0.79 |
| Gimap4 | GTPase, IMAP family member 4 | −0.77 |
| Akr1c12 | Aldo-keto reductase family 1, member C12 | −0.74 |
| Itgae | Integrin alpha E, epithelial associated | −0.70 |
| Ebf1 | Early B-cell factor 1 | −0.69 |
| Maob | Monoamine oxidase B | −0.68 |
| Tlr3 | Toll-like receptor 3 | −0.65 |
| Cd36 | CD36 antigen | −0.65 |
| Kmo | Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | −0.65 |
| Il13ra1 | Interleukin 13 receptor, alpha 1 | −0.65 |
| Stat4 | Signal transducer and activator of transcription 4 | −0.64 |
| Slamf7 | SLAM family member 7 | −0.63 |
| Il7r | Interleukin 7 receptor | −0.61 |
| Cdkn1b | Cyclin-dependent kinase inhibitor 1B | −0.60 |
| Sucnr1 | Succinate receptor 1 | −0.60 |
| Irf8 | Interferon regulatory factor 8 | −0.59 |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | −0.58 |
| Nov | Nephroblastoma overexpressed gene | −0.56 |
| Ptprg | Protein tyrosine phosphatase, receptor type, G | −0.55 |
| Socs2 | Suppressor of cytokine signaling 2 | −0.53 |
| Irf5 | Interferon regulatory factor 5 | −0.51 |
| Igfbp5 | Insulin-like growth factor–binding protein 5 | −0.50 |
| Slamf6 | SLAM family member 6 | −0.50 |
| Slc2a1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | −0.50 |
| Lef1 | Lymphoid enhancer-binding factor 1 | −0.49 |
| Cd96 | CD96 antigen | −0.49 |
See Table 1 for expansion of abbreviations.