Chelator dose at baseline and follow-up by liver and iron burden
| Chelator . | Chelator dose, mg/kg/d, mean (SD) . | ||||||
|---|---|---|---|---|---|---|---|
| Baseline LIC, mg/g dw . | Baseline cardiac T2*, ms . | ||||||
| < 4 . | 4 to < 7 . | 7 to < 15 . | ≥ 15 . | < 10 . | 10 to < 20 . | ≥ 20 . | |
| DFX | |||||||
| Baseline | 21.8 (10.6) | 23.3 (6.0) | 27.1 (6.3) | 28.5 (8.9) | 29.8 (10.9) | 30.7 (8.9) | 24.9 (8.0) |
| n | 28 | 37 | 69 | 35 | 12 | 22 | 69 |
| Follow-up | 25.1 (14.5) | 28.4 (7.1) | 29.0 (10.7) | 36.5 (18.8) | 39.0 (28.5) | 34.5 (15.0) | 26.9 (7.9) |
| n | 20 | 26 | 58 | 28 | 10 | 18 | 53 |
| P* | .47 | .004 | .28 | .06 | .42 | .31 | .11 |
| DFO | |||||||
| Baseline | 38.0 (13.2) | 40.7 (11.0) | 38.6 (12.1) | 36.7 (12.1) | 44.7 (5.4) | 43.0 (15.5) | 41.8 (10.5) |
| n | 16 | 17 | 23 | 14 | 6 | 8 | 24 |
| Follow-up | 39.7 (15.9) | 40.8 (8.5) | 35.9 (6.8) | 42.0 (9.7) | 41.5 (2.1) | 37.2 (17.2) | 43.9 (9.1) |
| n | 7 | 6 | 11 | 7 | 2 | 5 | 17 |
| P* | .44 | .47 | .36 | .25 | .50 | .68 | .66 |
| Chelator . | Chelator dose, mg/kg/d, mean (SD) . | ||||||
|---|---|---|---|---|---|---|---|
| Baseline LIC, mg/g dw . | Baseline cardiac T2*, ms . | ||||||
| < 4 . | 4 to < 7 . | 7 to < 15 . | ≥ 15 . | < 10 . | 10 to < 20 . | ≥ 20 . | |
| DFX | |||||||
| Baseline | 21.8 (10.6) | 23.3 (6.0) | 27.1 (6.3) | 28.5 (8.9) | 29.8 (10.9) | 30.7 (8.9) | 24.9 (8.0) |
| n | 28 | 37 | 69 | 35 | 12 | 22 | 69 |
| Follow-up | 25.1 (14.5) | 28.4 (7.1) | 29.0 (10.7) | 36.5 (18.8) | 39.0 (28.5) | 34.5 (15.0) | 26.9 (7.9) |
| n | 20 | 26 | 58 | 28 | 10 | 18 | 53 |
| P* | .47 | .004 | .28 | .06 | .42 | .31 | .11 |
| DFO | |||||||
| Baseline | 38.0 (13.2) | 40.7 (11.0) | 38.6 (12.1) | 36.7 (12.1) | 44.7 (5.4) | 43.0 (15.5) | 41.8 (10.5) |
| n | 16 | 17 | 23 | 14 | 6 | 8 | 24 |
| Follow-up | 39.7 (15.9) | 40.8 (8.5) | 35.9 (6.8) | 42.0 (9.7) | 41.5 (2.1) | 37.2 (17.2) | 43.9 (9.1) |
| n | 7 | 6 | 11 | 7 | 2 | 5 | 17 |
| P* | .44 | .47 | .36 | .25 | .50 | .68 | .66 |
For change in dose from baseline to follow-up for each chelator.