Reasons for changing chelator
| Reason for switch, n (%) . | Chelator switch DFO to DFX (N = 55) . | Chelator switch from DFX to DFO (N = 34)* . |
|---|---|---|
| Ferritin/LIC too high | 34 (61.8) | 10 (29.4) |
| Ferritin/LIC too low | 8 (14.5) | 1 (2.9) |
| Audiologic toxicity | 2 (3.6) | 0 (0.0) |
| Ophthalmologic toxicity | 0 (0.0) | 0 (0.0) |
| Nephrotoxicity | 0 (0.0) | 3 (8.8) |
| Cardiac disease or cardiac iron loading requiring intensification | 0 (0.0) | 4 (11.8) |
| Elevated alanine aminotransferase | 3 (5.5) | 5 (14.7) |
| Gastrointestinal side effects (nausea, diarrhea, abdominal pain) | 1 (1.8) | 5 (14.7) |
| Dislike taste/texture | 0 (0) | 1 (2.9) |
| Gastrointestinal bleeding | 0 (0.0) | 1 (2.9) |
| Local skin reactions/central access difficulty | 3 (5.5) | 0 (0.0) |
| Rash | 1 (1.8) | 2 (5.9) |
| Anxiety/palpitations | 0 (0) | 1 (2.9) |
| Missing | 3 (5.5) | 1 (2.9) |
| Reason for switch, n (%) . | Chelator switch DFO to DFX (N = 55) . | Chelator switch from DFX to DFO (N = 34)* . |
|---|---|---|
| Ferritin/LIC too high | 34 (61.8) | 10 (29.4) |
| Ferritin/LIC too low | 8 (14.5) | 1 (2.9) |
| Audiologic toxicity | 2 (3.6) | 0 (0.0) |
| Ophthalmologic toxicity | 0 (0.0) | 0 (0.0) |
| Nephrotoxicity | 0 (0.0) | 3 (8.8) |
| Cardiac disease or cardiac iron loading requiring intensification | 0 (0.0) | 4 (11.8) |
| Elevated alanine aminotransferase | 3 (5.5) | 5 (14.7) |
| Gastrointestinal side effects (nausea, diarrhea, abdominal pain) | 1 (1.8) | 5 (14.7) |
| Dislike taste/texture | 0 (0) | 1 (2.9) |
| Gastrointestinal bleeding | 0 (0.0) | 1 (2.9) |
| Local skin reactions/central access difficulty | 3 (5.5) | 0 (0.0) |
| Rash | 1 (1.8) | 2 (5.9) |
| Anxiety/palpitations | 0 (0) | 1 (2.9) |
| Missing | 3 (5.5) | 1 (2.9) |
All but 1 subject switched from DFO to DFX to DFO.