Patient characteristics (N = 327)
| Characteristic . | Baseline n (%) . | Follow-up n (%) . |
|---|---|---|
| Age at enrollment, y, mean (SD) | 22.2 (12.5) | |
| Sex, n (%) | ||
| Male | 156 (47.7) | |
| Female | 171 (52.3) | |
| Race, n (%)* | ||
| White | 160 (48.9) | |
| Black | 8 (2.4) | |
| Asian | 146 (44.6) | |
| Other | 9 (2.8) | |
| Missing | 4 (1.2) | |
| Diagnosis, n (%) | ||
| β-thalassemia, ≥ 8 transfusions/previous y | 291 (89.0) | |
| E-β-thalassemia, ≥ 8 transfusions/previous y | 31 (9.5) | |
| Homozygous α-thalassemia | 5 (1.5) | |
| Chelation, n (%) | ||
| DFO | 81 (24.8) | 43 (13.1) |
| DFX | 192 (58.7) | 172 (52.6) |
| DFP | 9 (2.8) | 9 (2.8) |
| DFO/DFP | 22 (6.7) | 34 (10.4) |
| DFO/DFX | 10 (3.1) | 18 (5.5) |
| No ongoing chelation | 13 (4.0) | 4 (1.2) |
| Missing chelation data | 47 (14.4) | |
| Iron assessment | ||
| Median ferritin, ng/mL (range) | 1271 (67.7-23 712) | 1103 (46.0-17 900) |
| Mean LIC, mg/g dw (SD) | 10.6 (8.9) | 7.70 (8.2) |
| Mean cardiac T2*, ms (SD) | 25.0 (13.7) | 26.7 (12.4) |
| Cardiac complications, n (%) | ||
| Congestive heart failure | 30 (9.2) | 31 (9.5)* |
| Supraventricular arrhythmia | 13 (4.0) | 15 (4.6)* |
| Ventricular arrhythmia | 14 (4.3) | 17 (5.2)* |
| Characteristic . | Baseline n (%) . | Follow-up n (%) . |
|---|---|---|
| Age at enrollment, y, mean (SD) | 22.2 (12.5) | |
| Sex, n (%) | ||
| Male | 156 (47.7) | |
| Female | 171 (52.3) | |
| Race, n (%)* | ||
| White | 160 (48.9) | |
| Black | 8 (2.4) | |
| Asian | 146 (44.6) | |
| Other | 9 (2.8) | |
| Missing | 4 (1.2) | |
| Diagnosis, n (%) | ||
| β-thalassemia, ≥ 8 transfusions/previous y | 291 (89.0) | |
| E-β-thalassemia, ≥ 8 transfusions/previous y | 31 (9.5) | |
| Homozygous α-thalassemia | 5 (1.5) | |
| Chelation, n (%) | ||
| DFO | 81 (24.8) | 43 (13.1) |
| DFX | 192 (58.7) | 172 (52.6) |
| DFP | 9 (2.8) | 9 (2.8) |
| DFO/DFP | 22 (6.7) | 34 (10.4) |
| DFO/DFX | 10 (3.1) | 18 (5.5) |
| No ongoing chelation | 13 (4.0) | 4 (1.2) |
| Missing chelation data | 47 (14.4) | |
| Iron assessment | ||
| Median ferritin, ng/mL (range) | 1271 (67.7-23 712) | 1103 (46.0-17 900) |
| Mean LIC, mg/g dw (SD) | 10.6 (8.9) | 7.70 (8.2) |
| Mean cardiac T2*, ms (SD) | 25.0 (13.7) | 26.7 (12.4) |
| Cardiac complications, n (%) | ||
| Congestive heart failure | 30 (9.2) | 31 (9.5)* |
| Supraventricular arrhythmia | 13 (4.0) | 15 (4.6)* |
| Ventricular arrhythmia | 14 (4.3) | 17 (5.2)* |
The number of cardiac complications at follow-up includes the number of events at baseline.