Multivariate analyses of transplantation outcomes for severe T-cell deficiency patients according to strategy of transplantation (MMRDT vs UCBT)
| . | HR . | 95% CI . | P . |
|---|---|---|---|
| 5-year OS | |||
| MMRDT vs UCBT | 1.15 | 0.71-1.87 | .58 |
| Year > 2001 | 1.08 | 0.71-1.65 | .72 |
| Omenn vs SCID | 1.99 | 1.16-3.39 | .01 |
| Failure to thrive | 0.55 | 0.33-0.91 | .02 |
| Diarrhea | 3.34 | 1.20-3.34 | .007 |
| Pretransplantation viral infection | 2.32 | 1.47-3.67 | .000 |
| RIC vs no conditioning | 0.24 | 0.12-0.47 | .000 |
| Myeloablative conditioning vs no conditioning | 0.36 | 0.20-0.66 | .001 |
| Use of ATG or other mAb | 1.73 | 1.05-2.85 | .032 |
| Discontinuation of IVIg replacement therapy | |||
| MMRDT vs UCBT | 1.70 | 1.08-2.69 | .023 |
| Year > 2001 | 1.52 | 0.97-2.39 | .07 |
| Omenn vs SCID | 0.68 | 0.34-1.32 | .25 |
| Failure to thrive | 0.76 | 0.48-1.23 | .27 |
| Diarrhea | 1.57 | 0.94-2.61 | .08 |
| Pretransplantation viral infection | 1.82 | 1.12-2.95 | .015 |
| RIC vs no conditioning | 2.13 | 0.92-4.96 | .08 |
| Myeloablative conditioning vs no conditioning | 3.23 | 1.47-7.08 | .003 |
| Use of ATG or other mAb | 0.64 | 0.39-1.04 | .07 |
| . | HR . | 95% CI . | P . |
|---|---|---|---|
| 5-year OS | |||
| MMRDT vs UCBT | 1.15 | 0.71-1.87 | .58 |
| Year > 2001 | 1.08 | 0.71-1.65 | .72 |
| Omenn vs SCID | 1.99 | 1.16-3.39 | .01 |
| Failure to thrive | 0.55 | 0.33-0.91 | .02 |
| Diarrhea | 3.34 | 1.20-3.34 | .007 |
| Pretransplantation viral infection | 2.32 | 1.47-3.67 | .000 |
| RIC vs no conditioning | 0.24 | 0.12-0.47 | .000 |
| Myeloablative conditioning vs no conditioning | 0.36 | 0.20-0.66 | .001 |
| Use of ATG or other mAb | 1.73 | 1.05-2.85 | .032 |
| Discontinuation of IVIg replacement therapy | |||
| MMRDT vs UCBT | 1.70 | 1.08-2.69 | .023 |
| Year > 2001 | 1.52 | 0.97-2.39 | .07 |
| Omenn vs SCID | 0.68 | 0.34-1.32 | .25 |
| Failure to thrive | 0.76 | 0.48-1.23 | .27 |
| Diarrhea | 1.57 | 0.94-2.61 | .08 |
| Pretransplantation viral infection | 1.82 | 1.12-2.95 | .015 |
| RIC vs no conditioning | 2.13 | 0.92-4.96 | .08 |
| Myeloablative conditioning vs no conditioning | 3.23 | 1.47-7.08 | .003 |
| Use of ATG or other mAb | 0.64 | 0.39-1.04 | .07 |
HR indicates hazard ratio; RIC, reduced-intensity conditioning; and ATG, antithymocyte globulin.