Table 4 Organ responses to bortezomib in... | American Society of Hematology

Table 4

Organ responses to bortezomib in patients treated at the recommended doses on each schedule or at lower doses on either schedule, and by hematologic response

Organ	Recommended dose groups		Lower doses	Hematologic response*
Organ	1.6 mg/m² QW	1.3 mg/m² BIW	Lower doses	CR/PR	No response
Renal, N	9	26	14	29	19
Response, n (%)	4 (44)	7 (27)	3 (21)	11 (38)	3 (16)
No change, n (%)	5 (56)	17 (65)	11 (79)	17 (59)	15 (79)
Progression, n (%)	0	2 (8)	0	1 (3)	1 (5)
Cardiac, N	10	20	9	22	14
Response,† n (%)	1 (10)	2 (10)	2 (22)	4 (18)	1 (7)
No change, n (%)	9 (90)	18 (90)	7 (78)	18 (82)	13 (93)
Hepatic, N	4	3	1	6	2
No change, n (%)	4 (100)	3 (100)	1 (100)	6 (100)	2 (100)
Neurologic, N	2	2	3	5	2
Response, n (%)	2 (100)	0	0	2 (40)	0
No change, n (%)	0	2 (100)	3 (100)	3 (60)	2 (100)
Any organ, N				38	24
Response, n (%)				12 (32)	3 (13)
No change, n (%)				25 (66)	20 (83)
Progression, n (%)				1 (3)	1 (4)

Organ	Recommended dose groups		Lower doses	Hematologic response*
Organ	1.6 mg/m² QW	1.3 mg/m² BIW	Lower doses	CR/PR	No response
Renal, N	9	26	14	29	19
Response, n (%)	4 (44)	7 (27)	3 (21)	11 (38)	3 (16)
No change, n (%)	5 (56)	17 (65)	11 (79)	17 (59)	15 (79)
Progression, n (%)	0	2 (8)	0	1 (3)	1 (5)
Cardiac, N	10	20	9	22	14
Response,† n (%)	1 (10)	2 (10)	2 (22)	4 (18)	1 (7)
No change, n (%)	9 (90)	18 (90)	7 (78)	18 (82)	13 (93)
Hepatic, N	4	3	1	6	2
No change, n (%)	4 (100)	3 (100)	1 (100)	6 (100)	2 (100)
Neurologic, N	2	2	3	5	2
Response, n (%)	2 (100)	0	0	2 (40)	0
No change, n (%)	0	2 (100)	3 (100)	3 (60)	2 (100)
Any organ, N				38	24
Response, n (%)				12 (32)	3 (13)
No change, n (%)				25 (66)	20 (83)
Progression, n (%)				1 (3)	1 (4)

QW indicates once weekly; BIW, twice weekly; CR, complete response; and PR, partial response.

In response-evaluable patient population.

†

Based on ≥ 2-mm decreases in mean left ventricular wall thickness.

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