Summary of published Ka values (M−1·s−1) of protease inhibition by PN-1
| Ka (M−1 × s−1) . | |||
|---|---|---|---|
| Enzyme . | Without heparin . | With heparin . | References . |
| Thrombin | 6-8.3 × 105 | 0.7-1.6 × 109 | 7,11 |
| Trypsin | 2.2-4.2 × 107 | 1 × 107 | 7,11 |
| uPA | 1.5-1.7 × 105 | 9.6 × 105 | 11, personal data* |
| tPA | 1.2-3 × 104 | 3.4 × 104 | personal data* |
| Plasmin | 1-2.3 × 105 | 1-4.1 × 105 | 7,11, personal data* |
| Factor Xa | 5.1 × 103 | 3.5 × 105 | 7 |
| Factor XIa | 7.9 × 104 | 1.7 × 106 | 12 |
| Activated protein C | 5.2 × 103 | 2.3 × 105 | 13 |
| Ka (M−1 × s−1) . | |||
|---|---|---|---|
| Enzyme . | Without heparin . | With heparin . | References . |
| Thrombin | 6-8.3 × 105 | 0.7-1.6 × 109 | 7,11 |
| Trypsin | 2.2-4.2 × 107 | 1 × 107 | 7,11 |
| uPA | 1.5-1.7 × 105 | 9.6 × 105 | 11, personal data* |
| tPA | 1.2-3 × 104 | 3.4 × 104 | personal data* |
| Plasmin | 1-2.3 × 105 | 1-4.1 × 105 | 7,11, personal data* |
| Factor Xa | 5.1 × 103 | 3.5 × 105 | 7 |
| Factor XIa | 7.9 × 104 | 1.7 × 106 | 12 |
| Activated protein C | 5.2 × 103 | 2.3 × 105 | 13 |
All constants determined at 37°C, except Evans et al,7 which was determined at 20°C.
PN-1 indicates protease nexin-1; tPA, tissue plasminogen activator; and uPA, urokinase plasminogen activator.
V.A., September 2001.