Characteristics of screened patients with SCD according to TRV*
| Characteristic . | TRV . | P† . | ||
|---|---|---|---|---|
| < 2.7 m/s . | 2.7-2.9 m/s . | ≥ 3.0 m/s . | ||
| Age, y | 34 ± 12 (403) | 41 ± 13 (141) | 44 ± 14 (82) | < .001 |
| Female sex, n (%) | 54 (403) | 56 (141) | 41 (82) | .08 |
| SCD genotype, SS/SC/SB+ or SB0/Other‡ | 68/23/5/4 (403) | 78/17/4/1 (141) | 85/14/0/1 (81) | .09 |
| 6MWD, m | 450 ± 96 (401) | 425 ± 103 (141) | 398 ± 91 (79) | < .001 |
| NT-proBNP, pg/mL | 108 ± 210 (380) | 276 ± 742 (132) | 2954 ± 8469 (75) | < .001** |
| NT-proBNP, log10 | 1.7 ± 0.5 (380) | 1.9 ± 0.7 (132) | 2.5 ± 0.9 (75) | < .001 |
| Blood pressure, mmHg | ||||
| Systolic | 118 ± 13 (403) | 121 ± 15 (140) | 123 ± 17 (81) | .01 |
| Diastolic | 69 ± 10 (403) | 68 ± 11 (140) | 68 ± 12 (81) | .56 |
| Mean arterial§ | 86 ± 10 (403) | 86 ± 11 (140) | 86 ± 12 (81) | .76 |
| Heart rate, bpm | 78 ± 12 (403) | 77 ± 13 (140) | 78 ± 12 (81) | .92 |
| Oxygen saturation, % | 97 ± 3 (402) | 96 ± 3 (138) | 95 ± 4 (81) | < .001 |
| Body surface area,¶ m2 | 1.78 ± 0.22 (399) | 1.82 ± 0.21 (139) | 1.83 ± 0.23 (77) | .09 |
| Current smoking, % | 15 (403) | 13 (140) | 27 (81) | .01 |
| History of hydroxyurea therapy,# % | 49 (403) | 54 (141) | 49 (81) | .59 |
| History of acute chest syndrome,# % | 60 (403) | 71 (141) | 58 (81) | .05 |
| History of stroke,# % | 9 (403) | 13 (141) | 17 (81) | .08 |
| History of asthma,# % | 19 (403) | 24 (141) | 22 (81) | .46 |
| History of cardiovascular problems,# % | 37 (403) | 65 (141) | 72 (81) | < .001 |
| History of renal problems# | 38 (403) | 50 (141) | 58 (81) | .001 |
| History of leg ulcers,# % | 15 (403) | 28 (141) | 31 (81) | < .001 |
| > 20 blood transfusions/lifetime,# % | 27 (403) | 40 (141) | 54 (81) | < .001 |
| History of priapism,# % of men | 29 (185) | 34 (62) | 30 (47) | .74 |
| Hemoglobin, g/dL | 9.7 ± 1.9 (397) | 8.9 ± 1.9 (137) | 8.4 ± 2.1 (78) | < .001 |
| White blood cell count, ×103/μL | 9 ± 4 (397) | 10 ± 4 (137) | 11 ± 4 (78) | .002 |
| Platelet count, ×103/μL | 359 ± 147 (396) | 346 ± 116 (137) | 351 ± 122 (78) | .99 |
| Blood urea nitrogen, mg/dL | 9 ± 6 (398) | 11 ± 7 (138) | 17 ± 12 (79) | < .001 |
| Creatinine, mg/dL | 0.8 ± 0.4 (397) | 0.9 ± 0.7 (138) | 1.5 ± 2.0 (80) | < .001 |
| Total bilirubin, mg/dL | 2.8 ± 2.9 (396) | 3.2 ± 2.6 (137) | 3.5 ± 2.6 (80) | .002 |
| Alkaline phosphatase, U/L | 98 ± 57 (397) | 100 ± 47 (137) | 118 ± 58 (80) | .008 |
| Alanine aminotransferase, U/L | 27 ± 23 (397) | 31 ± 22 (137) | 28 ± 19 (80) | .02 |
| Aspartate aminotransferase, U/L | 41 ± 34 (388) | 49 ± 27 (137) | 54 ± 34 (78) | < .001 |
| Lactate dehydrogenase, IU/L | 420 ± 288 (369) | 477 ± 340 (129) | 522 ± 264 (74) | .003 |
| Characteristic . | TRV . | P† . | ||
|---|---|---|---|---|
| < 2.7 m/s . | 2.7-2.9 m/s . | ≥ 3.0 m/s . | ||
| Age, y | 34 ± 12 (403) | 41 ± 13 (141) | 44 ± 14 (82) | < .001 |
| Female sex, n (%) | 54 (403) | 56 (141) | 41 (82) | .08 |
| SCD genotype, SS/SC/SB+ or SB0/Other‡ | 68/23/5/4 (403) | 78/17/4/1 (141) | 85/14/0/1 (81) | .09 |
| 6MWD, m | 450 ± 96 (401) | 425 ± 103 (141) | 398 ± 91 (79) | < .001 |
| NT-proBNP, pg/mL | 108 ± 210 (380) | 276 ± 742 (132) | 2954 ± 8469 (75) | < .001** |
| NT-proBNP, log10 | 1.7 ± 0.5 (380) | 1.9 ± 0.7 (132) | 2.5 ± 0.9 (75) | < .001 |
| Blood pressure, mmHg | ||||
| Systolic | 118 ± 13 (403) | 121 ± 15 (140) | 123 ± 17 (81) | .01 |
| Diastolic | 69 ± 10 (403) | 68 ± 11 (140) | 68 ± 12 (81) | .56 |
| Mean arterial§ | 86 ± 10 (403) | 86 ± 11 (140) | 86 ± 12 (81) | .76 |
| Heart rate, bpm | 78 ± 12 (403) | 77 ± 13 (140) | 78 ± 12 (81) | .92 |
| Oxygen saturation, % | 97 ± 3 (402) | 96 ± 3 (138) | 95 ± 4 (81) | < .001 |
| Body surface area,¶ m2 | 1.78 ± 0.22 (399) | 1.82 ± 0.21 (139) | 1.83 ± 0.23 (77) | .09 |
| Current smoking, % | 15 (403) | 13 (140) | 27 (81) | .01 |
| History of hydroxyurea therapy,# % | 49 (403) | 54 (141) | 49 (81) | .59 |
| History of acute chest syndrome,# % | 60 (403) | 71 (141) | 58 (81) | .05 |
| History of stroke,# % | 9 (403) | 13 (141) | 17 (81) | .08 |
| History of asthma,# % | 19 (403) | 24 (141) | 22 (81) | .46 |
| History of cardiovascular problems,# % | 37 (403) | 65 (141) | 72 (81) | < .001 |
| History of renal problems# | 38 (403) | 50 (141) | 58 (81) | .001 |
| History of leg ulcers,# % | 15 (403) | 28 (141) | 31 (81) | < .001 |
| > 20 blood transfusions/lifetime,# % | 27 (403) | 40 (141) | 54 (81) | < .001 |
| History of priapism,# % of men | 29 (185) | 34 (62) | 30 (47) | .74 |
| Hemoglobin, g/dL | 9.7 ± 1.9 (397) | 8.9 ± 1.9 (137) | 8.4 ± 2.1 (78) | < .001 |
| White blood cell count, ×103/μL | 9 ± 4 (397) | 10 ± 4 (137) | 11 ± 4 (78) | .002 |
| Platelet count, ×103/μL | 359 ± 147 (396) | 346 ± 116 (137) | 351 ± 122 (78) | .99 |
| Blood urea nitrogen, mg/dL | 9 ± 6 (398) | 11 ± 7 (138) | 17 ± 12 (79) | < .001 |
| Creatinine, mg/dL | 0.8 ± 0.4 (397) | 0.9 ± 0.7 (138) | 1.5 ± 2.0 (80) | < .001 |
| Total bilirubin, mg/dL | 2.8 ± 2.9 (396) | 3.2 ± 2.6 (137) | 3.5 ± 2.6 (80) | .002 |
| Alkaline phosphatase, U/L | 98 ± 57 (397) | 100 ± 47 (137) | 118 ± 58 (80) | .008 |
| Alanine aminotransferase, U/L | 27 ± 23 (397) | 31 ± 22 (137) | 28 ± 19 (80) | .02 |
| Aspartate aminotransferase, U/L | 41 ± 34 (388) | 49 ± 27 (137) | 54 ± 34 (78) | < .001 |
| Lactate dehydrogenase, IU/L | 420 ± 288 (369) | 477 ± 340 (129) | 522 ± 264 (74) | .003 |
Values within parentheses are percentages, unless otherwise indicated.
Percentages are based on the number of subjects (n) in a given group for the population analyzed. ± values are means ± SD. Log values (on a base 10 scale) were used to analyze laboratory measurements. Values in parentheses are total numbers.
Stratum differences were assessed using ANOVA for continuous variables and χ2 tests for categorical variables.
SB+ or SB0 = S beta+ thalassemia or S beta0 thalassemia, respectively.
Mean arterial pressure was calculated with the use of the following equation: mean arterial pressure = 1/3 systolic blood pressure + 2/3 diastolic blood pressure.
The body surface area was calculated using the Mosteller formula: body surface area = square root of (height in cm × weight in kg)/3600.
Medical history was primarily captured via self-report.
This analysis is of the log10 value and is a duplicate of the one noted in the next line of the table. Because the actual values were especially non-normal, we have reported the transformed means ± SD as well as the original.