Nonhematologic side effects
| Toxicity . | Thalidomide, n (%) (N = 44) . | Lenalidomide, n (%) (N = 41) . | Lenalidomide plus prednisone, n (%) (N = 40) . | P . | |||
|---|---|---|---|---|---|---|---|
| All grades . | Grades 3-4 . | All grades . | Grades 3-4 . | All grades . | Grades 3-4 . | ||
| Thrombosis | 1 (2) | 1 (2) | 2 (5) | 1 (2) | 2 (5) | 2 (5) | .77 |
| Edema | 9 (20) | 1 (2) | 9 (22) | 1 (2) | 4 (10) | 2 (5) | .31 |
| Fatigue | 15 (34) | 1 (2) | 14 (35) | 5 (12) | 6 (15) | 4 (10) | .08 |
| Neuropathy | 23 (52) | 1 (2) | 2 (5) | 0 | 6 (15) | 0 | .001 |
| Increased liver enzymes | 0 | 0 | 4 (10) | 1 (2) | 3 (7) | 2 (5) | .12 |
| Rash | 16 (36) | 1 (2) | 7 (18) | 3 (7) | 15 (37) | 0 | .07 |
| Bleeding | 0 | 0 | 0 | 0 | 1 (3) | 1 (3) | .34 |
| Toxicity . | Thalidomide, n (%) (N = 44) . | Lenalidomide, n (%) (N = 41) . | Lenalidomide plus prednisone, n (%) (N = 40) . | P . | |||
|---|---|---|---|---|---|---|---|
| All grades . | Grades 3-4 . | All grades . | Grades 3-4 . | All grades . | Grades 3-4 . | ||
| Thrombosis | 1 (2) | 1 (2) | 2 (5) | 1 (2) | 2 (5) | 2 (5) | .77 |
| Edema | 9 (20) | 1 (2) | 9 (22) | 1 (2) | 4 (10) | 2 (5) | .31 |
| Fatigue | 15 (34) | 1 (2) | 14 (35) | 5 (12) | 6 (15) | 4 (10) | .08 |
| Neuropathy | 23 (52) | 1 (2) | 2 (5) | 0 | 6 (15) | 0 | .001 |
| Increased liver enzymes | 0 | 0 | 4 (10) | 1 (2) | 3 (7) | 2 (5) | .12 |
| Rash | 16 (36) | 1 (2) | 7 (18) | 3 (7) | 15 (37) | 0 | .07 |
| Bleeding | 0 | 0 | 0 | 0 | 1 (3) | 1 (3) | .34 |