Efficacy of therapy
| Parameter . | Thalidomide (N = 44) . | Lenalidomide (N = 41) . | Lenalidomide plus prednisone . | P . |
|---|---|---|---|---|
| Response | .06 | |||
| Overall, median (%) [95% CI] | 7 (16) [7-30] | 14 (34) [20-51] | 15 (38) [23-54] | |
| CR, median (%) [95% CI] | 1 (2) [0-12] | 2 (5) [1-17] | 2 (5) [1-7] | |
| PR, median (%) [95% CI] | 1 (2) [0-12] | 5 (12) [4-26] | 4 (10) [3-24] | |
| CI, median (%) [95% CI]* | 5 (12) [4-25] | 7 (17) [7-32] | 9 (23) [11-38] | |
| Hemoglobin level, median (%) [95% CI] | 5 | 4 | 4 | |
| Platelet count, median (%) [95% CI] | 1 | 1 | NA | |
| ANC, median (%) [95% CI] | NA | NA | 1 | |
| Spleen, median (%) [95% CI] | NA | 3 | 4 | |
| Median follow-up (range), mo | 116 (16-121) | 57 (5-67) | 42 (6 to ≥49) | < .0001 |
| Median response duration (range), mo | 13 (4-30) | 7 (1-41) | 34 (1 to ≥49) | .042 |
| Median time to first response (range), wk | 8 (3-15) | 17 (2-29) | 11 (2-45) | .0066 |
| Median time to best response (range), wk | 8 (3-32) | 18 (2-39) | 14 (2-79) | .0138 |
| Parameter . | Thalidomide (N = 44) . | Lenalidomide (N = 41) . | Lenalidomide plus prednisone . | P . |
|---|---|---|---|---|
| Response | .06 | |||
| Overall, median (%) [95% CI] | 7 (16) [7-30] | 14 (34) [20-51] | 15 (38) [23-54] | |
| CR, median (%) [95% CI] | 1 (2) [0-12] | 2 (5) [1-17] | 2 (5) [1-7] | |
| PR, median (%) [95% CI] | 1 (2) [0-12] | 5 (12) [4-26] | 4 (10) [3-24] | |
| CI, median (%) [95% CI]* | 5 (12) [4-25] | 7 (17) [7-32] | 9 (23) [11-38] | |
| Hemoglobin level, median (%) [95% CI] | 5 | 4 | 4 | |
| Platelet count, median (%) [95% CI] | 1 | 1 | NA | |
| ANC, median (%) [95% CI] | NA | NA | 1 | |
| Spleen, median (%) [95% CI] | NA | 3 | 4 | |
| Median follow-up (range), mo | 116 (16-121) | 57 (5-67) | 42 (6 to ≥49) | < .0001 |
| Median response duration (range), mo | 13 (4-30) | 7 (1-41) | 34 (1 to ≥49) | .042 |
| Median time to first response (range), wk | 8 (3-15) | 17 (2-29) | 11 (2-45) | .0066 |
| Median time to best response (range), wk | 8 (3-32) | 18 (2-39) | 14 (2-79) | .0138 |
ANC indicates absolute neutrophil count; and CI, confidence interval.
Patients could have CI involving several lineages.