CIS identified in the BCP-ALL samples whose homologous human chromosomal location was found to be a recurrent region of copy number (CN) change in human ETV6-RUNX1 leukemias
| Mouse CIS (no. insertions) . | Homologous human region (chromosome: bp) . | No. patients . | CN changes in patient samples . | CN lesion size (Mb): mean ± SD (median) . |
|---|---|---|---|---|
| Fam46d (4) | X: 79589304–79616318 | 10 | 1.4, 1.34, 1.36, 1.28, 1.53, 1.11, 1, 2.99, 0.85, 1.23 | 124 ± 43 (150) |
| Gata1 (2) | X: 48645231–48659263 | 9 | 2.47, 1.34, 1.36, 1.28, 1.11, 1, 2.99, 0.85, 1.23 | 132 ± 34 (151) |
| L3mbtl3 (3) | 6: 130336865–130339827 | 5 | 0.88, 1.28, 0.84, 1.55, 3.17 | 110 ± 57 (87) |
| CIS7:37320759 (12) | 19: 31962394–32030766 | 3 | 1.68, 1.65, 1.06 | 23 ± 29 (7) |
| Cebpa (8) | 19: 33765960–33835715 | 3 | 1.68, 1.65, 1.06 | 23 ± 29 (7) |
| Gm1968 (5) | 3: 193728382–193781161 | 3 | 0.98, 0.94, 1.59 | 37 ± 42 (20) |
| Psd3 (5) | 8: 18414769–18459953 | 3 | 1.16, 0.93, 2.6 | 58 ± 37 (37) |
| Mouse CIS (no. insertions) . | Homologous human region (chromosome: bp) . | No. patients . | CN changes in patient samples . | CN lesion size (Mb): mean ± SD (median) . |
|---|---|---|---|---|
| Fam46d (4) | X: 79589304–79616318 | 10 | 1.4, 1.34, 1.36, 1.28, 1.53, 1.11, 1, 2.99, 0.85, 1.23 | 124 ± 43 (150) |
| Gata1 (2) | X: 48645231–48659263 | 9 | 2.47, 1.34, 1.36, 1.28, 1.11, 1, 2.99, 0.85, 1.23 | 132 ± 34 (151) |
| L3mbtl3 (3) | 6: 130336865–130339827 | 5 | 0.88, 1.28, 0.84, 1.55, 3.17 | 110 ± 57 (87) |
| CIS7:37320759 (12) | 19: 31962394–32030766 | 3 | 1.68, 1.65, 1.06 | 23 ± 29 (7) |
| Cebpa (8) | 19: 33765960–33835715 | 3 | 1.68, 1.65, 1.06 | 23 ± 29 (7) |
| Gm1968 (5) | 3: 193728382–193781161 | 3 | 0.98, 0.94, 1.59 | 37 ± 42 (20) |
| Psd3 (5) | 8: 18414769–18459953 | 3 | 1.16, 0.93, 2.6 | 58 ± 37 (37) |
In total, 50 ETV6-RUNX1 patient samples were analyzed by single-nucleotide polymorphism array, and the CN changes for the relevant lesions shown. Deletions correspond to CN < 2 and amplifications to CN > 2. The LiftOver tool (http://genome.ucsc.edu/cgi-bin/hgLiftOver) was used to find the associated human chromosomal region for each mouse CIS gene (using the GRCh37/hg19 assembly). Statistical significance for each CIS was calculated (using 1000 randomly selected Refseq genes) and a cut-off of P < 0.2 was used.