Genes silenced by promoter DNA hypermethylation and histone H3 hypoacetylation in AML
| Name . | Symbol . | Gb acc . | Fold change (mRNA) Aza/untreated . | H3 acetylation (log fold change) AML/CD34 . | Adjusted P . | Direction of change . |
|---|---|---|---|---|---|---|
| Peroxiredoxin 2 | PRDX2 | L19185 | 2.3075 | −1.3056 | .0059 | H3Ac in AML decreased |
| Trefoil factor 3 (intestinal) | TFF3 | NM_003226 | 3.1108 | −1.3698 | .0204 | H3Ac in AML decreased |
| MHC, class I, A | HLA-A | AI923492 | 2.2161 | −1.2975 | .0137 | H3Ac in AML decreased |
| MHC, class I, A | HLA-A | AA573862 | 2.8716 | −1.2975 | .0137 | H3Ac in AML decreased |
| Catenin (cadherin-associated protein), delta 1 | CTNND1 | NM_001331 | 2.0985 | −1.0649 | .0291 | H3Ac in AML decreased |
| TIMP metallopeptidase inhibitor 1 | TIMP1 | NM_003254 | 3.5313 | −1.1289 | .0179 | H3Ac in AML decreased |
| Cylindromatosis (turban tumor syndrome) | CYLD | BF516433 | 2.9026 | −1.0625 | .0286 | H3Ac in AML decreased |
| Nuclear factor, IL- 3 regulated | NFIL3 | NM_005384 | 2.0471 | −1.0622 | .0403 | H3Ac in AML decreased |
| TNF (ligand) superfamily, member 10 /// TNF (ligand) superfamily, member 10 | TNFSF10 | NM_003810 | 2.4509 | −1.0049 | .0380 | H3Ac in AML decreased |
| TNF (ligand) superfamily, member 10 /// TNF (ligand) superfamily, member 10 | TNFSF10 | NM_003810 | 2.7388 | −1.0049 | .0380 | H3Ac in AML decreased |
| ATP-binding cassette, sub-family G (WHITE), member 1 | ABCG1 | NM_004915 | 2.2372 | −1.0052 | .0126 | H3Ac in AML decreased |
| Protein tyrosine phosphatase, receptor type, C | PTPRC | AI809341 | 2.4576 | −0.8651 | .0425 | H3Ac in AML decreased |
| SH3 domain binding glutamic acid-rich protein like 3 /// SH3 domain binding glutamic acid-rich protein like 3 | SH3BGRL3 | NM_031286 | 2.4592 | −1.1272 | .0203 | H3Ac in AML decreased |
| Name . | Symbol . | Gb acc . | Fold change (mRNA) Aza/untreated . | H3 acetylation (log fold change) AML/CD34 . | Adjusted P . | Direction of change . |
|---|---|---|---|---|---|---|
| Peroxiredoxin 2 | PRDX2 | L19185 | 2.3075 | −1.3056 | .0059 | H3Ac in AML decreased |
| Trefoil factor 3 (intestinal) | TFF3 | NM_003226 | 3.1108 | −1.3698 | .0204 | H3Ac in AML decreased |
| MHC, class I, A | HLA-A | AI923492 | 2.2161 | −1.2975 | .0137 | H3Ac in AML decreased |
| MHC, class I, A | HLA-A | AA573862 | 2.8716 | −1.2975 | .0137 | H3Ac in AML decreased |
| Catenin (cadherin-associated protein), delta 1 | CTNND1 | NM_001331 | 2.0985 | −1.0649 | .0291 | H3Ac in AML decreased |
| TIMP metallopeptidase inhibitor 1 | TIMP1 | NM_003254 | 3.5313 | −1.1289 | .0179 | H3Ac in AML decreased |
| Cylindromatosis (turban tumor syndrome) | CYLD | BF516433 | 2.9026 | −1.0625 | .0286 | H3Ac in AML decreased |
| Nuclear factor, IL- 3 regulated | NFIL3 | NM_005384 | 2.0471 | −1.0622 | .0403 | H3Ac in AML decreased |
| TNF (ligand) superfamily, member 10 /// TNF (ligand) superfamily, member 10 | TNFSF10 | NM_003810 | 2.4509 | −1.0049 | .0380 | H3Ac in AML decreased |
| TNF (ligand) superfamily, member 10 /// TNF (ligand) superfamily, member 10 | TNFSF10 | NM_003810 | 2.7388 | −1.0049 | .0380 | H3Ac in AML decreased |
| ATP-binding cassette, sub-family G (WHITE), member 1 | ABCG1 | NM_004915 | 2.2372 | −1.0052 | .0126 | H3Ac in AML decreased |
| Protein tyrosine phosphatase, receptor type, C | PTPRC | AI809341 | 2.4576 | −0.8651 | .0425 | H3Ac in AML decreased |
| SH3 domain binding glutamic acid-rich protein like 3 /// SH3 domain binding glutamic acid-rich protein like 3 | SH3BGRL3 | NM_031286 | 2.4592 | −1.1272 | .0203 | H3Ac in AML decreased |