D-FISH results for LTC-IC experiments with CD34+CD38− cells isolated from CML CP patients
| Patient no. . | Ph+/total cells (%) . | ||||||
|---|---|---|---|---|---|---|---|
| Baseline . | No-Drug . | Imatinib . | SB216763 . | Imatinib SB216763 . | Dasatinib . | Dasatinib SB216763 . | |
| CP16 | 223/263 (85) | 93/112 (83) | 86/121 (71) | 32/118 (27) | 2/88 (2) | 86/94 (92) | 105/121 (87) |
| CP17 | 273/314 (87) | 82/126 (65) | 128/156 (82) | 34/106 (32) | 3/96 (4) | 129/148 (87) | 120/136 (88) |
| CP 18 | 242/276 (88) | 103/138 (75) | 119/140 (85) | 21/84 (25) | 2/42 (4) | 132/174 (76) | 77/107 (72) |
| Patient no. . | Ph+/total cells (%) . | ||||||
|---|---|---|---|---|---|---|---|
| Baseline . | No-Drug . | Imatinib . | SB216763 . | Imatinib SB216763 . | Dasatinib . | Dasatinib SB216763 . | |
| CP16 | 223/263 (85) | 93/112 (83) | 86/121 (71) | 32/118 (27) | 2/88 (2) | 86/94 (92) | 105/121 (87) |
| CP17 | 273/314 (87) | 82/126 (65) | 128/156 (82) | 34/106 (32) | 3/96 (4) | 129/148 (87) | 120/136 (88) |
| CP 18 | 242/276 (88) | 103/138 (75) | 119/140 (85) | 21/84 (25) | 2/42 (4) | 132/174 (76) | 77/107 (72) |
Colonies were harvested after LTC-IC experiments combined with prior cell expansion under cytokine-enriched liquid suspension cultures pooled for each drug treatment condition and then FISH was performed on the cells from these colonies and cells at baseline.