Summary of transplantation experiments
| Genotype . | No. of mice . | Mean fluorescence . | EGFP+ cell transplantations . | Total cell transplantations . | Median survival time, d (range) . | Median WBC day 18, ×103/μL (range) . |
|---|---|---|---|---|---|---|
| pMmiRCtrl–BCR-ABL | 5 | 63.7 | 5000 | 200 000 | 23.2 (19-30) | 85 (42-135) |
| pMmiRRaf1–BCR-ABL | 4 | 60.5 | 5000 | 200 000 | 31.3 (26-34) | 52 (23-88) |
| pMmiRp53–BCR-ABL | 5 | 59.6 | 5000 | 200 000 | 22.2 (19-27) | 129 (46-242) |
| pMmiRCtrl–BCR-ABL | 3 | 178.6 | 5000 | 200 000 | 25.0 (22-27) | 188 (169-209) |
| pMmiRRaf1–BCR-ABL | 3 | 160.8 | 5000 | 200 000 | 40.0 (34-50) | 98 (20-150) |
| pMmiRp53–BCR-ABL | 3 | 138.7 | 5000 | 200 000 | 21.3 (19-24) | ND |
| pMmiRCtrl–BCR-ABL | 5 | 31.0 | 5000 | 190 000 | 24.6 (22-28) | 107 (78-140) |
| pMmiRRaf1–BCR-ABL | 5 | 23.9 | 5000 | 190 000 | 33.4 (24-41) | 69 (40-124) |
| pMmiRCtrl–BCR-ABL | 5 | 31.1 | 5000 | 190 000 | 29.8 (18-37) | 52 (31-86) |
| pMmiRRaf1–BCR-ABL | 4 | 27.5 | 5000 | 190 000 | 41.0 (32-46) | 26 (10-39) |
| pMmiRBRAF–BCR-ABL | 5 | 32.5 | 5000 | 190 000 | 29.2 (25-32) | 82 (31-168) |
| pMmiRCtrl–BCR-ABL | 5 | 34.2 | 5000 | 200 000 | 25.0 (19-29) | ND |
| pMmiRRaf1–BCR-ABL | 5 | 28.0 | 5000 | 200 000 | 34.3 (31-38) | ND |
| pMmiRBRAF–BCR-ABL | 5 | 35.0 | 5000 | 200 000 | 24.4 (21-30) | ND |
| pMmiRCtrl–BCR-ABL | 10 | 65.6 | 5000 | 200 000 | 25.7 (21-29) | 101 (33-228) |
| pMmiRRaf1(6)–BCR-ABL | 10 | 50.9 | 5000 | 200 000 | 39.6 (25-70) | 23 (5-70) |
| Genotype . | No. of mice . | Mean fluorescence . | EGFP+ cell transplantations . | Total cell transplantations . | Median survival time, d (range) . | Median WBC day 18, ×103/μL (range) . |
|---|---|---|---|---|---|---|
| pMmiRCtrl–BCR-ABL | 5 | 63.7 | 5000 | 200 000 | 23.2 (19-30) | 85 (42-135) |
| pMmiRRaf1–BCR-ABL | 4 | 60.5 | 5000 | 200 000 | 31.3 (26-34) | 52 (23-88) |
| pMmiRp53–BCR-ABL | 5 | 59.6 | 5000 | 200 000 | 22.2 (19-27) | 129 (46-242) |
| pMmiRCtrl–BCR-ABL | 3 | 178.6 | 5000 | 200 000 | 25.0 (22-27) | 188 (169-209) |
| pMmiRRaf1–BCR-ABL | 3 | 160.8 | 5000 | 200 000 | 40.0 (34-50) | 98 (20-150) |
| pMmiRp53–BCR-ABL | 3 | 138.7 | 5000 | 200 000 | 21.3 (19-24) | ND |
| pMmiRCtrl–BCR-ABL | 5 | 31.0 | 5000 | 190 000 | 24.6 (22-28) | 107 (78-140) |
| pMmiRRaf1–BCR-ABL | 5 | 23.9 | 5000 | 190 000 | 33.4 (24-41) | 69 (40-124) |
| pMmiRCtrl–BCR-ABL | 5 | 31.1 | 5000 | 190 000 | 29.8 (18-37) | 52 (31-86) |
| pMmiRRaf1–BCR-ABL | 4 | 27.5 | 5000 | 190 000 | 41.0 (32-46) | 26 (10-39) |
| pMmiRBRAF–BCR-ABL | 5 | 32.5 | 5000 | 190 000 | 29.2 (25-32) | 82 (31-168) |
| pMmiRCtrl–BCR-ABL | 5 | 34.2 | 5000 | 200 000 | 25.0 (19-29) | ND |
| pMmiRRaf1–BCR-ABL | 5 | 28.0 | 5000 | 200 000 | 34.3 (31-38) | ND |
| pMmiRBRAF–BCR-ABL | 5 | 35.0 | 5000 | 200 000 | 24.4 (21-30) | ND |
| pMmiRCtrl–BCR-ABL | 10 | 65.6 | 5000 | 200 000 | 25.7 (21-29) | 101 (33-228) |
| pMmiRRaf1(6)–BCR-ABL | 10 | 50.9 | 5000 | 200 000 | 39.6 (25-70) | 23 (5-70) |
WBC indicates white blood cell.