Genes altered only in EBV-negative PEL
| Gene ID . | Gene name . | Location . | Category . | Amplification . | Deletion . | Unchanged . |
|---|---|---|---|---|---|---|
| ACSBG2 | Acyl-CoA synthetase bubblegum family member 2 | 19p13.3 | Metabolism | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | VG1 | |
| FUT3 | CD174; Fucosyltransferase 3 | 19p13.3 | Metabolism | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | VG1 | |
| HLA-DRB5 | MHC-II, DR-β-5 | 6p21.3 | MHC | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| IKBKB | IκB kinase β | 8p11.2 | Cell signaling | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| ITPR1 | Inositol-1,4,5-triphosphate receptor, type 1 | 3p26.1 | Cell signaling | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| RAF1 | v-Raf murine leukemia homolog 1 | 3p25 | Oncogene | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| RFX2 | Regulatory factor X, 2 | 19p13.3 | Transcription | BC3, BCBL, BCLM, BCP1, HHB2 | TY1, VG1 | |
| ARAP2 | Arf and RhoGAP adaptor protein 2 | 4p14 | Cytoskeleton | BC3, BCBL, BCP1, HHB2, TY1 | BCLM, VG1 | |
| BRCA2 | Breast cancer 2, early onset | 13q12.3 | Tumor suppressor | BC3, BCBL, BCLM, HHB2, TY1 | BCP1, VG1 | |
| CADM2 | Cell adhesion molecule 2 | 3p11.1 | Cell adhesion | BC3, BCBL, BCP1, HHB2, TY1 | BCLM, VG1 | |
| CDH9 | Cadherin 9, type 2 | 5p14.1 | Cell adhesion | HHB2 | BC3, BCBL, BCLM, BCP1, TY1 | VG1 |
| CDYL | Chromodomain protein, Y-like | 6p25.1 | Transcription | VG1 | BCBL, BCLM, BCP1, HHB2, TY1 | BC3 |
| CHD1 | Chromodomain helicase DNA binding protein 1 | 5q21.1 | Transcription | HHB2 | BCBL, BCLM, BCP1, TY1, VG1 | BC3 |
| EPHA3 | Ephrin receptor A3 | 3p11.2 | Development | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| EPHA5 | Ephrin receptor A5 | 4q13.1 | Development | VG1 | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | |
| EDIL3 | EGF-like repeats and discoidin-I like domain 3 | 5q14.3 | Cell adhesion | HHB2 | BC3, BCBL, BCLM, BCP1, TY1 | VG1 |
| GRID2 | Glutamate receptor, ionotropic, δ 2 | 4q22.1 | Development | BC3, BCBL, BCLM, TY1, VG1 | BCP1, HHB2 | |
| HBS1L | Hsp70 subfamily B suppressor 1-like protein | 6q23.3 | Development | BCBL, BCLM, BCP1, HHB2, TY1 | BC3, VG1 | |
| LRFN5 | Leucine rich repeat and fibronectin type III domain containing 5 | 14q21.1 | Cell adhesion | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| MEF2C | Myocyte enhancer factor 2 | 5q14.3 | Transcription | HHB2 | BC3, BCBL, BCP1, TY1, VG1 | BCLM |
| PCDH9 | Protocadherin 9 | 13q21.32 | Cell adhesion | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| RREB1 | Ras-responsive element binding protein 1 | 6p24.3 | Transcription | BC3, VG1 | BCBL, BCP1, HHB2, TY1 | BCLM |
| ZEB1 | Zinc finger E-box binding homeobox 1 | 10p11.2 | Transcription | BC3, BCBL, BCLM, BCP1, HHB2 | TY1, VG1 |
| Gene ID . | Gene name . | Location . | Category . | Amplification . | Deletion . | Unchanged . |
|---|---|---|---|---|---|---|
| ACSBG2 | Acyl-CoA synthetase bubblegum family member 2 | 19p13.3 | Metabolism | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | VG1 | |
| FUT3 | CD174; Fucosyltransferase 3 | 19p13.3 | Metabolism | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | VG1 | |
| HLA-DRB5 | MHC-II, DR-β-5 | 6p21.3 | MHC | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| IKBKB | IκB kinase β | 8p11.2 | Cell signaling | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| ITPR1 | Inositol-1,4,5-triphosphate receptor, type 1 | 3p26.1 | Cell signaling | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| RAF1 | v-Raf murine leukemia homolog 1 | 3p25 | Oncogene | BCBL, BCLM, BCP1, TY1, VG1 | BC3, HHB2 | |
| RFX2 | Regulatory factor X, 2 | 19p13.3 | Transcription | BC3, BCBL, BCLM, BCP1, HHB2 | TY1, VG1 | |
| ARAP2 | Arf and RhoGAP adaptor protein 2 | 4p14 | Cytoskeleton | BC3, BCBL, BCP1, HHB2, TY1 | BCLM, VG1 | |
| BRCA2 | Breast cancer 2, early onset | 13q12.3 | Tumor suppressor | BC3, BCBL, BCLM, HHB2, TY1 | BCP1, VG1 | |
| CADM2 | Cell adhesion molecule 2 | 3p11.1 | Cell adhesion | BC3, BCBL, BCP1, HHB2, TY1 | BCLM, VG1 | |
| CDH9 | Cadherin 9, type 2 | 5p14.1 | Cell adhesion | HHB2 | BC3, BCBL, BCLM, BCP1, TY1 | VG1 |
| CDYL | Chromodomain protein, Y-like | 6p25.1 | Transcription | VG1 | BCBL, BCLM, BCP1, HHB2, TY1 | BC3 |
| CHD1 | Chromodomain helicase DNA binding protein 1 | 5q21.1 | Transcription | HHB2 | BCBL, BCLM, BCP1, TY1, VG1 | BC3 |
| EPHA3 | Ephrin receptor A3 | 3p11.2 | Development | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| EPHA5 | Ephrin receptor A5 | 4q13.1 | Development | VG1 | BC3, BCBL, BCLM, BCP1, HHB2, TY1 | |
| EDIL3 | EGF-like repeats and discoidin-I like domain 3 | 5q14.3 | Cell adhesion | HHB2 | BC3, BCBL, BCLM, BCP1, TY1 | VG1 |
| GRID2 | Glutamate receptor, ionotropic, δ 2 | 4q22.1 | Development | BC3, BCBL, BCLM, TY1, VG1 | BCP1, HHB2 | |
| HBS1L | Hsp70 subfamily B suppressor 1-like protein | 6q23.3 | Development | BCBL, BCLM, BCP1, HHB2, TY1 | BC3, VG1 | |
| LRFN5 | Leucine rich repeat and fibronectin type III domain containing 5 | 14q21.1 | Cell adhesion | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| MEF2C | Myocyte enhancer factor 2 | 5q14.3 | Transcription | HHB2 | BC3, BCBL, BCP1, TY1, VG1 | BCLM |
| PCDH9 | Protocadherin 9 | 13q21.32 | Cell adhesion | BC3, BCBL, BCLM, BCP1, TY1 | HHB2, VG1 | |
| RREB1 | Ras-responsive element binding protein 1 | 6p24.3 | Transcription | BC3, VG1 | BCBL, BCP1, HHB2, TY1 | BCLM |
| ZEB1 | Zinc finger E-box binding homeobox 1 | 10p11.2 | Transcription | BC3, BCBL, BCLM, BCP1, HHB2 | TY1, VG1 |