HCDR3 rearrangements of lymphoproliferations from CDR-deleted and wild-type mice
| Animal . | VH . | VH . | N . | DH . | N . | JH . | JH . | CDR3 length . | Diagnosis . |
|---|---|---|---|---|---|---|---|---|---|
| CDR+/− #40 | V286 | SR | GVE | IL | N | W | 3 | 9 | DLBCL |
| CDR+/+ #51 | V265 | TR | R | GSSY | YYAMDY | 4 | 13 | CLL/SLL | |
| CDR+/− #179-J4 | >V251 | ARD | P | NWD | Y | YYAMDY | 4 | 14 | CLL/SLL |
| CDRfl/−CD19-Cre #39 | V054 | AR | S | DYR | SQY | YYAMDY | 4 | 15 | CLL/SLL |
| CDRfl/+CD19-Cre #47 | V186 | AR | IYDGYY | YFDY | 2 | 12 | CLL/SLL | ||
| CDRfl/−CD19-Cre #224 | V122 | ARD | DGYY | YFDY | 2 | 11 | CLL/SLL | ||
| CDR+/−CD19-Cre #328 | V332 | AR | E | EA | G | YYAMDY | 4 | 12 | CLL/SLL |
| CDRfl/−CD19-Cre #304-J1 | V304 | AS | HDYD | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #308-J2 | V126 | AR | G | YDYD | DYFDY | 2 | 12 | CLL/SLL | |
| CDR+/− #117 | V188 | LR | EDK | YDG | FDF | 2 | 11 | DLBCL | |
| CDRfl/−CD19-Cre #184-J4 | V027 | VR | D | DYD | AMDY | 4 | 10 | CLL/SLL | |
| CDR+/− #147 | V054 | AR | C | TTVVAT | KE | NAMDY | 4 | 16 | CLL/SLL |
| CDR+/− #67 | V332 | AR | R | DYGSSY | WYFDV | 1 | 14 | CLL/SLL | |
| CDRfl/flCD19-Cre #202 | V332 | AR | I | YYGSSY | WYFDV | 1 | 14 | CLL/SLL | |
| CDRfl/flCD19-Cre #27 | V120 | ARD | HYGSSY | AWFAY | 3 | 14 | CLL/SLL | ||
| CDRfl/flCD19-Cre #178 | V126 | AR | DP | YYYGSS | L | YYFDY | 2 | 16 | CLL/SLL |
| CDR+/+ #114 | V235 | MRY | GNY | WYFDV | 1 | 11 | MBL | ||
| CDR+/− #181 | V235 | MRY | GNY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDR+/−CD19-Cre #225 | V235 | MRY | SNY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #184-J1 | V163 | AS | YYGY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #308-J1 | V328 | AR | PS | LPY | WYFDV | 1 | 12 | CLL/SLL | |
| CDR+/− #174 | V313 | AR | GVY | YDGYY | PP | FDV | 1 | 15 | CLL/SLL |
| CDRfl/−CD19-Cre #330 | V286 | AR | ERL | DYGY | E | AWFAY | 3 | 15 | CLL/SLL |
| CDR+/− #179-J1 | V190 | AK | E | PYYSNY | D | YWYFDV | 1 | 16 | CLL/SLL |
| CDRfl/−CD19-Cre #304-J2 | V346 | AR | DYSN | YDY | 2 | 9 | CLL/SLL | ||
| CDRfl/flCD19-Cre #14 | V563 | A | G | NW | DFDY | 2 | 8 | CLL/SLL | |
| CDR+/+CD19-Cre #30 | V364 | AR | WDFDV | 1 | 7 | CLL/SLL |
| Animal . | VH . | VH . | N . | DH . | N . | JH . | JH . | CDR3 length . | Diagnosis . |
|---|---|---|---|---|---|---|---|---|---|
| CDR+/− #40 | V286 | SR | GVE | IL | N | W | 3 | 9 | DLBCL |
| CDR+/+ #51 | V265 | TR | R | GSSY | YYAMDY | 4 | 13 | CLL/SLL | |
| CDR+/− #179-J4 | >V251 | ARD | P | NWD | Y | YYAMDY | 4 | 14 | CLL/SLL |
| CDRfl/−CD19-Cre #39 | V054 | AR | S | DYR | SQY | YYAMDY | 4 | 15 | CLL/SLL |
| CDRfl/+CD19-Cre #47 | V186 | AR | IYDGYY | YFDY | 2 | 12 | CLL/SLL | ||
| CDRfl/−CD19-Cre #224 | V122 | ARD | DGYY | YFDY | 2 | 11 | CLL/SLL | ||
| CDR+/−CD19-Cre #328 | V332 | AR | E | EA | G | YYAMDY | 4 | 12 | CLL/SLL |
| CDRfl/−CD19-Cre #304-J1 | V304 | AS | HDYD | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #308-J2 | V126 | AR | G | YDYD | DYFDY | 2 | 12 | CLL/SLL | |
| CDR+/− #117 | V188 | LR | EDK | YDG | FDF | 2 | 11 | DLBCL | |
| CDRfl/−CD19-Cre #184-J4 | V027 | VR | D | DYD | AMDY | 4 | 10 | CLL/SLL | |
| CDR+/− #147 | V054 | AR | C | TTVVAT | KE | NAMDY | 4 | 16 | CLL/SLL |
| CDR+/− #67 | V332 | AR | R | DYGSSY | WYFDV | 1 | 14 | CLL/SLL | |
| CDRfl/flCD19-Cre #202 | V332 | AR | I | YYGSSY | WYFDV | 1 | 14 | CLL/SLL | |
| CDRfl/flCD19-Cre #27 | V120 | ARD | HYGSSY | AWFAY | 3 | 14 | CLL/SLL | ||
| CDRfl/flCD19-Cre #178 | V126 | AR | DP | YYYGSS | L | YYFDY | 2 | 16 | CLL/SLL |
| CDR+/+ #114 | V235 | MRY | GNY | WYFDV | 1 | 11 | MBL | ||
| CDR+/− #181 | V235 | MRY | GNY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDR+/−CD19-Cre #225 | V235 | MRY | SNY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #184-J1 | V163 | AS | YYGY | WYFDV | 1 | 11 | CLL/SLL | ||
| CDRfl/−CD19-Cre #308-J1 | V328 | AR | PS | LPY | WYFDV | 1 | 12 | CLL/SLL | |
| CDR+/− #174 | V313 | AR | GVY | YDGYY | PP | FDV | 1 | 15 | CLL/SLL |
| CDRfl/−CD19-Cre #330 | V286 | AR | ERL | DYGY | E | AWFAY | 3 | 15 | CLL/SLL |
| CDR+/− #179-J1 | V190 | AK | E | PYYSNY | D | YWYFDV | 1 | 16 | CLL/SLL |
| CDRfl/−CD19-Cre #304-J2 | V346 | AR | DYSN | YDY | 2 | 9 | CLL/SLL | ||
| CDRfl/flCD19-Cre #14 | V563 | A | G | NW | DFDY | 2 | 8 | CLL/SLL | |
| CDR+/+CD19-Cre #30 | V364 | AR | WDFDV | 1 | 7 | CLL/SLL |
The order of cases is according to the alignment obtained after hierarchical clustering of all HCDR3 sequences. Cases that showed ≥ 80% amino acid sequence homology in the CDR3 are grouped.