Suggested strategy for conversion from dabigatran or rivaroxaban to warfarin
| Calculated creatinine clearance, mL/min . | Dabigatran: start day with warfarin* . | Rivaroxaban: start day with warfarin* . |
|---|---|---|
| > 50 | Day −3 | Day −4 |
| 31-50 | Day −2 | Day −3 |
| 15-30 | Day −1 | Day −2 |
| Calculated creatinine clearance, mL/min . | Dabigatran: start day with warfarin* . | Rivaroxaban: start day with warfarin* . |
|---|---|---|
| > 50 | Day −3 | Day −4 |
| 31-50 | Day −2 | Day −3 |
| 15-30 | Day −1 | Day −2 |
Dabigatran/rivaroxaban is stopped on day 0. The longer overlap with rivaroxaban is justified by its half-life being shorter than that of dabigatran and by the concern about thromboembolic events shortly after transitioning from rivaroxaban to warfarin.6