Predicted percentage of subjects achieving FVIII trough levels > 1% and 3% of normal at a specified dose regimen of rFVIII or rFVIIIFc
| Time after dosing, d . | rFVIII . | rFVIIIFc . | ||
|---|---|---|---|---|
| 25 IU/kg . | 65 IU/kg . | 25 IU/kg . | 65 IU/kg . | |
| Percentage of subjects with FVIII trough levels > 1% | ||||
| 3 | 40.0 | 67.8 | 92.6 | 99.0 |
| 4 | 12.2 | 31.0 | 71.2 | 90.0 |
| 5 | 4.20 | 13.6 | 39.4 | 71.6 |
| 7 | 0.200 | 1.40 | 7.80 | 26.4 |
| Percentage of subjects with FVIII trough levels > 3% | ||||
| 3 | 10.6 | 34.6 | 62.2 | 91.0 |
| 4 | 1.60 | 11.0 | 25.4 | 66.4 |
| 5 | 0.200 | 3.20 | 7.00 | 36.2 |
| 7 | 0 | 0.200 | 0.400 | 6.60 |
| Time after dosing, d . | rFVIII . | rFVIIIFc . | ||
|---|---|---|---|---|
| 25 IU/kg . | 65 IU/kg . | 25 IU/kg . | 65 IU/kg . | |
| Percentage of subjects with FVIII trough levels > 1% | ||||
| 3 | 40.0 | 67.8 | 92.6 | 99.0 |
| 4 | 12.2 | 31.0 | 71.2 | 90.0 |
| 5 | 4.20 | 13.6 | 39.4 | 71.6 |
| 7 | 0.200 | 1.40 | 7.80 | 26.4 |
| Percentage of subjects with FVIII trough levels > 3% | ||||
| 3 | 10.6 | 34.6 | 62.2 | 91.0 |
| 4 | 1.60 | 11.0 | 25.4 | 66.4 |
| 5 | 0.200 | 3.20 | 7.00 | 36.2 |
| 7 | 0 | 0.200 | 0.400 | 6.60 |