Table 2

Top 50 genes most highly expressed by the intermediate monocyte subset sorted according to decreasing absolute fold change values

Gene nameFold change normalized to intermediate*
ClassicNonclassic
GDNF family receptor-α2 (GFRA2) −5.25 −2.62 
Natural killer cell group 7 sequence (NKG7) −4.86 −1.03 
Plasmalemma vesicle associated protein (PLVAP) −4.53 −1.28 
Placenta-specific 8 (PLAC8) −3.35 −1.33 
MARCKS-like 1 (MARCKSL1) −3.23 −1.01 
E2F transcription factor 2 (E2F2) −3.05 −1.22 
Quanylate binding protein 4 (GBP4) −3.03 −1.00 
C-type lectin domain family 10 member A (CLEC10A) −1.48 −2.73 
Complement component 1 q subcomponent C chain (C1QC) −2.72 −1.10 
Epithelial V-like antigen 1 (EVA1) −1.07 −2.67 
c-mer proto-oncogene tyrosine kinase (MERTK) −2.65 −1.04 
Monoglyceride lipase (MGLL) −2.59 −1.06 
Development and differentiation enhancing factor-like 1 (DDEFL1) −2.47 −1.00 
Macrophage receptor with collagenous structure (MARCO) −1.68 −2.44 
Nuclear receptor subfamily 1 group H member 3 (NR1H3) −2.41 −1.57 
Fructose-16-bisphosphatase 1 (FBP1) −2.39 −1.36 
Acid phosphatase 2 lysosomal (ACP2) −2.36 −1.08 
Guanylate binding protein 1 interferon-inducible 67kDa (GBP1) −2.27 −1.26 
G protein-coupled bile acid receptor 1 (GPBAR1) −2.24 −1.20 
SAM and SH3 domain containing 1 (SASH1) −2.24 −1.36 
Olfactomedin 1 (OLFM1) −1.21 −2.20 
TIMP metallopeptidase inhibitor 1 (TIMP1) −2.17 −1.08 
Major histocompatibility complex class II DO-α (HLA-DOA) −1.74 −2.15 
Calcium/calmodulin-dependent protein kinase I (CAMK1) −2.14 −1.04 
Protein O-fucosyltransferase 1 (POFUT1) −2.13 −1.02 
Erythrocyte membrane protein band 4.1-like 3 (EPB41L3) −2.09 −1.21 
H19 imprinted maternally expressed untranslated mRNA (H19) −2.08 −2.11 
Stearoyl-CoA desaturase (SCD) −1.69 −2.04 
Coactosin-like 1 (COTL1) −2.03 −1.07 
Solute carrier family 29 member 1 (SLC29A1) −2.02 −1.02 
DNA-damage-inducible transcript 4 (DDIT4) −1.14 −2.01 
Transglutaminase 2 (TGM2) −2.00 −1.67 
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) −1.99 −1.00 
Activating transcription factor 5 (ATF5) −1.48 −1.99 
Glycoprotein A33 (GPA33) −1.98 −1.04 
Zinc finger protein 703 (ZNF703) −1.98 −1.05 
Sorting nexin 5 (SNX5) −1.96 −1.01 
C-type lectin domain family 10 member A (CLEC10A) −1.37 −1.96 
Tubulin-α ubiquitous (K-ALPHA-1) −1.92 −1.17 
Major histocompatibility complex class II DP-β 1 (HLA-DPB1) −1.46 −1.91 
Dehydrogenase/reductase member 9 (DHRS9) −1.41 −1.90 
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) −1.89 −1.21 
ral guanine nucleotide dissociation stimulator-like 1 (RGL1) −1.89 −1.51 
PR domain containing 1 with ZNF domain (PRDM1) −1.04 −1.89 
Fatty acid desaturase 1 (FADS1) −1.05 −1.88 
Solute carrier family 2 member 8 (SLC2A8) −1.87 −1.22 
c-src tyrosine kinase (CSK) −1.86 −1.08 
Isochorismatase domain containing 2 (ISOC2) −1.82 −1.10 
CD300c antigen (CD300C) −1.81 −1.19 
FYVE RhoGEF and PH domain containing 2 (FGD2) −1.78 −1.04 
Gene nameFold change normalized to intermediate*
ClassicNonclassic
GDNF family receptor-α2 (GFRA2) −5.25 −2.62 
Natural killer cell group 7 sequence (NKG7) −4.86 −1.03 
Plasmalemma vesicle associated protein (PLVAP) −4.53 −1.28 
Placenta-specific 8 (PLAC8) −3.35 −1.33 
MARCKS-like 1 (MARCKSL1) −3.23 −1.01 
E2F transcription factor 2 (E2F2) −3.05 −1.22 
Quanylate binding protein 4 (GBP4) −3.03 −1.00 
C-type lectin domain family 10 member A (CLEC10A) −1.48 −2.73 
Complement component 1 q subcomponent C chain (C1QC) −2.72 −1.10 
Epithelial V-like antigen 1 (EVA1) −1.07 −2.67 
c-mer proto-oncogene tyrosine kinase (MERTK) −2.65 −1.04 
Monoglyceride lipase (MGLL) −2.59 −1.06 
Development and differentiation enhancing factor-like 1 (DDEFL1) −2.47 −1.00 
Macrophage receptor with collagenous structure (MARCO) −1.68 −2.44 
Nuclear receptor subfamily 1 group H member 3 (NR1H3) −2.41 −1.57 
Fructose-16-bisphosphatase 1 (FBP1) −2.39 −1.36 
Acid phosphatase 2 lysosomal (ACP2) −2.36 −1.08 
Guanylate binding protein 1 interferon-inducible 67kDa (GBP1) −2.27 −1.26 
G protein-coupled bile acid receptor 1 (GPBAR1) −2.24 −1.20 
SAM and SH3 domain containing 1 (SASH1) −2.24 −1.36 
Olfactomedin 1 (OLFM1) −1.21 −2.20 
TIMP metallopeptidase inhibitor 1 (TIMP1) −2.17 −1.08 
Major histocompatibility complex class II DO-α (HLA-DOA) −1.74 −2.15 
Calcium/calmodulin-dependent protein kinase I (CAMK1) −2.14 −1.04 
Protein O-fucosyltransferase 1 (POFUT1) −2.13 −1.02 
Erythrocyte membrane protein band 4.1-like 3 (EPB41L3) −2.09 −1.21 
H19 imprinted maternally expressed untranslated mRNA (H19) −2.08 −2.11 
Stearoyl-CoA desaturase (SCD) −1.69 −2.04 
Coactosin-like 1 (COTL1) −2.03 −1.07 
Solute carrier family 29 member 1 (SLC29A1) −2.02 −1.02 
DNA-damage-inducible transcript 4 (DDIT4) −1.14 −2.01 
Transglutaminase 2 (TGM2) −2.00 −1.67 
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) −1.99 −1.00 
Activating transcription factor 5 (ATF5) −1.48 −1.99 
Glycoprotein A33 (GPA33) −1.98 −1.04 
Zinc finger protein 703 (ZNF703) −1.98 −1.05 
Sorting nexin 5 (SNX5) −1.96 −1.01 
C-type lectin domain family 10 member A (CLEC10A) −1.37 −1.96 
Tubulin-α ubiquitous (K-ALPHA-1) −1.92 −1.17 
Major histocompatibility complex class II DP-β 1 (HLA-DPB1) −1.46 −1.91 
Dehydrogenase/reductase member 9 (DHRS9) −1.41 −1.90 
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) −1.89 −1.21 
ral guanine nucleotide dissociation stimulator-like 1 (RGL1) −1.89 −1.51 
PR domain containing 1 with ZNF domain (PRDM1) −1.04 −1.89 
Fatty acid desaturase 1 (FADS1) −1.05 −1.88 
Solute carrier family 2 member 8 (SLC2A8) −1.87 −1.22 
c-src tyrosine kinase (CSK) −1.86 −1.08 
Isochorismatase domain containing 2 (ISOC2) −1.82 −1.10 
CD300c antigen (CD300C) −1.81 −1.19 
FYVE RhoGEF and PH domain containing 2 (FGD2) −1.78 −1.04 
*

Obtained by calculating the MFI values of classical or nonclassical relative to intermediate.

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