Patient and donor characteristics
| Characteristics . | No. of patients . |
|---|---|
| Median patient age, y (range) | 40 (16-70) |
| Sex | |
| Male | 47 |
| Female | 36 |
| Underlying disease | |
| AML (CR1/CR2/CR3/REF) | 52 (12/15/1/24) |
| ALL (CR1/CR2/REF) | 16 (3/3/10) |
| MDS (RA/RARS/RCMD) | 6 (1/1/4) |
| MDS (RAEB/CMMoL) | 9 (7/2) |
| Previous HCT | |
| HLA-matched sibling HCT | 7 |
| UD-HCT | 5 |
| Autologous HCT | 5 |
| Donors (of patients) | |
| Offspring | 38 |
| Mothers | 24 |
| Siblings | 21 |
| Donor sex | |
| Male | 45 |
| Female | 38 |
| Median donor age, y (range) | 36 (3-68) |
| No. of donor-patient HLA-A, -B, and -DR mismatch (by antigen) | |
| GVHD direction, 0/1/2/3 | 1/10/32/40 |
| Rejection direction, 1/2/3 | 13/32/38 |
| No. of donor patient HLA-A, -B, -C, and DRB1 mismatch (by allele) | |
| GVH direction, 1/2/3/4/unknown | 1/6/20/32/24 |
| Rejection direction, 1/2/3/4/unknown | 2/5/18/34/24 |
| Donor-patient NK-cell alloreactivity | |
| Yes/no/unknown | 10/49/24 |
| CMV IgG serology of patients | |
| Positive | 82 |
| Negative | 1 |
| CMV IgG serology of donors | |
| Positive | 80 |
| Negative | 3 |
| Characteristics . | No. of patients . |
|---|---|
| Median patient age, y (range) | 40 (16-70) |
| Sex | |
| Male | 47 |
| Female | 36 |
| Underlying disease | |
| AML (CR1/CR2/CR3/REF) | 52 (12/15/1/24) |
| ALL (CR1/CR2/REF) | 16 (3/3/10) |
| MDS (RA/RARS/RCMD) | 6 (1/1/4) |
| MDS (RAEB/CMMoL) | 9 (7/2) |
| Previous HCT | |
| HLA-matched sibling HCT | 7 |
| UD-HCT | 5 |
| Autologous HCT | 5 |
| Donors (of patients) | |
| Offspring | 38 |
| Mothers | 24 |
| Siblings | 21 |
| Donor sex | |
| Male | 45 |
| Female | 38 |
| Median donor age, y (range) | 36 (3-68) |
| No. of donor-patient HLA-A, -B, and -DR mismatch (by antigen) | |
| GVHD direction, 0/1/2/3 | 1/10/32/40 |
| Rejection direction, 1/2/3 | 13/32/38 |
| No. of donor patient HLA-A, -B, -C, and DRB1 mismatch (by allele) | |
| GVH direction, 1/2/3/4/unknown | 1/6/20/32/24 |
| Rejection direction, 1/2/3/4/unknown | 2/5/18/34/24 |
| Donor-patient NK-cell alloreactivity | |
| Yes/no/unknown | 10/49/24 |
| CMV IgG serology of patients | |
| Positive | 82 |
| Negative | 1 |
| CMV IgG serology of donors | |
| Positive | 80 |
| Negative | 3 |
REF indicates refractory disease; RA, refractory anemia; RARS, refractory anemia with ring sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; RAEB, refractory anemia with excess blasts; CMMoL, chronic myelomonocytic leukemia; UD, unrelated donor; and NK, natural killer.