Summary of toxicities encountered during T + E therapy
| . | Cycle 1, no. (%) of 84 patients . | Total, no. (%) of 273 patients . |
|---|---|---|
| Hospitalizations | 49 (58) | 66 (24) |
| Documented infections | 30 (36) | 50 (18) |
| Skin/cellulitis | 6 | 8 |
| Pneumonia | 18 | 23 |
| Sinusitis | 1 | 2 |
| Gastrointestinal | 1 | 2 |
| Genitourinary | 4 | 5 |
| Bacteremia | 7 | 10 |
| Neutropenic fever | 20 (24) | 31 (11) |
| Drug-related toxicities | ||
| Neurotoxicity (grade 1-4) | 19* | 22‡ |
| Oral mucositis (> grade 2) | 6 | 9 |
| Gastrointestinal (> grade 2) | 2 | 4 |
| Hyperbilirubinemia (> grade 2) | 10 | 16 |
| Renal (> grade 2) | 14 | 17 |
| Dehydration (> grade 2) | 13 | 16 |
| Rash (> grade 2) | 3 | 4 |
| Fatigue (> grade 2) | 15 | 26 |
| Cardiac (grade 1-5) | 3† | 6§ |
| Death | 10 (12) | 14 (5) |
| Infection | 6 | 9 |
| Blood | 3 | 3 |
| Lung | 3 | 6 |
| Cardiac | 1 | 2 |
| Multiorgan | 3 | 3 |
| . | Cycle 1, no. (%) of 84 patients . | Total, no. (%) of 273 patients . |
|---|---|---|
| Hospitalizations | 49 (58) | 66 (24) |
| Documented infections | 30 (36) | 50 (18) |
| Skin/cellulitis | 6 | 8 |
| Pneumonia | 18 | 23 |
| Sinusitis | 1 | 2 |
| Gastrointestinal | 1 | 2 |
| Genitourinary | 4 | 5 |
| Bacteremia | 7 | 10 |
| Neutropenic fever | 20 (24) | 31 (11) |
| Drug-related toxicities | ||
| Neurotoxicity (grade 1-4) | 19* | 22‡ |
| Oral mucositis (> grade 2) | 6 | 9 |
| Gastrointestinal (> grade 2) | 2 | 4 |
| Hyperbilirubinemia (> grade 2) | 10 | 16 |
| Renal (> grade 2) | 14 | 17 |
| Dehydration (> grade 2) | 13 | 16 |
| Rash (> grade 2) | 3 | 4 |
| Fatigue (> grade 2) | 15 | 26 |
| Cardiac (grade 1-5) | 3† | 6§ |
| Death | 10 (12) | 14 (5) |
| Infection | 6 | 9 |
| Blood | 3 | 3 |
| Lung | 3 | 6 |
| Cardiac | 1 | 2 |
| Multiorgan | 3 | 3 |