Table 5

Association between activating KIR genes and ALL, including patients with B-ALL and T-ALL

GenePatients (n = 175), n (%)Control subjects (n = 245), n (%)Univariate analysis
Adjusted analysis*
OR (95% CI)POR (95% CI)P
2DS1 39 (22.4) 102 (41.6) 0.41 (0.26-0.63) 5.1 × 10−5 0.48 (0.29-0.80) .005 
2DS2 39 (22.3) 138 (56.3) 0.22 (0.14-0.34) 1.5 × 10−11 0.27 (0.16-0.44) 1.14 × 10−7 
2DS3 19 (10.9) 83 (33.9) 0.24 (0.14-0.41) 2.8 × 10−7 0.44 (0.24-0.80) .008 
2DS4 71 (41.3) 139 (56.7) 0.54 (0.36-0.79) .002 0.52 (0.33-0.82) .005 
2DS5 34 (19.5) 104 (42.4) 0.33 (0.21-0.52) 1.5 × 10−6 0.43 (0.26-0.72) .001 
3DS1 33 (18.7) 101 (41.2) 0.33 (0.21-0.52) 2.1 × 10−6 0.53 (0.32-0.89) .016 
GenePatients (n = 175), n (%)Control subjects (n = 245), n (%)Univariate analysis
Adjusted analysis*
OR (95% CI)POR (95% CI)P
2DS1 39 (22.4) 102 (41.6) 0.41 (0.26-0.63) 5.1 × 10−5 0.48 (0.29-0.80) .005 
2DS2 39 (22.3) 138 (56.3) 0.22 (0.14-0.34) 1.5 × 10−11 0.27 (0.16-0.44) 1.14 × 10−7 
2DS3 19 (10.9) 83 (33.9) 0.24 (0.14-0.41) 2.8 × 10−7 0.44 (0.24-0.80) .008 
2DS4 71 (41.3) 139 (56.7) 0.54 (0.36-0.79) .002 0.52 (0.33-0.82) .005 
2DS5 34 (19.5) 104 (42.4) 0.33 (0.21-0.52) 1.5 × 10−6 0.43 (0.26-0.72) .001 
3DS1 33 (18.7) 101 (41.2) 0.33 (0.21-0.52) 2.1 × 10−6 0.53 (0.32-0.89) .016 

The prefix KIR is not shown with the gene names.

OR indicates odds ratio; and CI, confidence interval.

*

Logistic regression analysis adjusted for the effect of other genes in the table.

KIR2DS4 was considered absent when the PCR amplified only the 22-bp deleted amplicon. It was considered present when the nonmutant amplicon was observed on the gel with or without the mutant band.

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