Table 1 Autophagy induction in CML cells... | American Society of Hematology

Table 1

Autophagy induction in CML cells after various drug treatments

Drug	Main drug target	Cell type	Drug affect	Autophagy inhibitor	Affect of drug and autophagy inhibitor	Reference
Crotoxin	Not known	Cell line (K562)	Apoptosis and autophagy induction	3-MA NH₄Cl	Increased cell death	80
SAHA	Histone deacetylases	Cell lines, primary CML MNC	Apoptosis and autophagy induction	3-MA CQ	Increased cell death	81,82
Bafetinib	BCR-ABL	Cell line (K562)	Apoptosis and autophagy induction	CQ 3-MA	Increased cell death	83
Imatinib	BCR-ABL	Cell line (K562)	Apoptosis and autophagy induction	CQ	Increased cell death	84
Imatinib, dasatinib	BCR-ABL	Cell lines, primary CD34⁺ cells, including CD34⁺38⁻	Apoptosis and autophagy induction	CQ Bafilomycin A₁	Increased cell death	49,50
Imatinib	BCR-ABL	K562	Apoptosis and autophagy induction	3-MA	Increased cell death	85
OSI-027	mTOR	Cell line (K562)	Apoptosis and autophagy induction	CQ	Increased cell death	88
Resveratrol	Not known AMPK?	Cell lines, primary CD34⁺ cells	Apoptosis and autophagy induction	Bafilomycin A₁	Decreased cell death	89

Drug	Main drug target	Cell type	Drug affect	Autophagy inhibitor	Affect of drug and autophagy inhibitor	Reference
Crotoxin	Not known	Cell line (K562)	Apoptosis and autophagy induction	3-MA NH₄Cl	Increased cell death	80
SAHA	Histone deacetylases	Cell lines, primary CML MNC	Apoptosis and autophagy induction	3-MA CQ	Increased cell death	81,82
Bafetinib	BCR-ABL	Cell line (K562)	Apoptosis and autophagy induction	CQ 3-MA	Increased cell death	83
Imatinib	BCR-ABL	Cell line (K562)	Apoptosis and autophagy induction	CQ	Increased cell death	84
Imatinib, dasatinib	BCR-ABL	Cell lines, primary CD34⁺ cells, including CD34⁺38⁻	Apoptosis and autophagy induction	CQ Bafilomycin A₁	Increased cell death	49,50
Imatinib	BCR-ABL	K562	Apoptosis and autophagy induction	3-MA	Increased cell death	85
OSI-027	mTOR	Cell line (K562)	Apoptosis and autophagy induction	CQ	Increased cell death	88
Resveratrol	Not known AMPK?	Cell lines, primary CD34⁺ cells	Apoptosis and autophagy induction	Bafilomycin A₁	Decreased cell death	89

AMPK indicates AMP-activated protein kinase; BCR-ABL, breakpoint cluster region-Abelson murine leukemia; CML, chronic myeloid leukemia; CQ, chloroquine; 3-MA, 3-methyladenine; MNC, mononuclear cell; mTOR, mammalian target of rapamycin; and SAHA, suberoylanilide hydroxamic acid.

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