Predisposing risk factors for mucormycosis in patients with hematologic malignancies and/or stem cell transplantation
| Prolonged (> 3 wk) and severe (ANC < 200) neutropenia |
| Monocytopenia (< 100 mm3) |
| Prolonged (> 3 wk) high-dose systemic corticosteroids (eg, prednisone or equivalent of > 1 mg/kg/d) |
| Iron overload (assessed by high iron indices, high iron storage by MRI, or high iron staining in bone marrow biopsy) |
| High-risk SCT (eg, matched-unrelated donor SCT, haploidentical donor SCT, cord blood SCT, T cell-depleted SCT) |
| Severe GVHD and its treatment (especially corticosteroids) |
| Prolonged hyperglycemia (fasting serum glucose > 200 mg/dL), corticosteroid-associated hyperglycemia, diabetes mellitus |
| Colonization by mucormycetes or heavy environmental exposure? |
| Previous exposure to Aspergillus-active antifungal agents, especially voriconazole? |
| Relapsed leukemia |
| Prolonged (> 3 wk) and severe (ANC < 200) neutropenia |
| Monocytopenia (< 100 mm3) |
| Prolonged (> 3 wk) high-dose systemic corticosteroids (eg, prednisone or equivalent of > 1 mg/kg/d) |
| Iron overload (assessed by high iron indices, high iron storage by MRI, or high iron staining in bone marrow biopsy) |
| High-risk SCT (eg, matched-unrelated donor SCT, haploidentical donor SCT, cord blood SCT, T cell-depleted SCT) |
| Severe GVHD and its treatment (especially corticosteroids) |
| Prolonged hyperglycemia (fasting serum glucose > 200 mg/dL), corticosteroid-associated hyperglycemia, diabetes mellitus |
| Colonization by mucormycetes or heavy environmental exposure? |
| Previous exposure to Aspergillus-active antifungal agents, especially voriconazole? |
| Relapsed leukemia |
ANC indicates absolute neutrophil count.