Patient characteristics
| Characteristic . | GIMEMA (n = 331) . | HOVON (n = 333) . | IFM-I (n = 321) . | IFM-II (n = 229) . | NMSG (n = 357) . | TMSG (n = 114) . |
|---|---|---|---|---|---|---|
| Median age, y | 72.5 | 72.6 | 69.4 | 78.5 | 74.4 | 70.6 |
| Sex, % | ||||||
| Male | 54 | 56 | 54 | 45 | 55 | 54 |
| Female | 46 | 44 | 46 | 55 | 45 | 46 |
| DS stage, % | ||||||
| DS I | 0 | 0 | 10 | 9 | 15 | 5 |
| DS II | 38 | 26 | 26 | 23 | 36 | 53 |
| DS III | 62 | 74 | 64 | 68 | 45 | 40 |
| Not known | 0 | 0 | 0 | 0 | 4 | 2 |
| ISS, % | ||||||
| ISS 1 | 19 | 25 | 31 | 22 | 16 | 18 |
| ISS 2 | 38 | 24 | 34 | 38 | 40 | 35 |
| ISS 3 | 23 | 18 | 27 | 28 | 33 | 38 |
| Not known | 20 | 32 | 8 | 12 | 11 | 10 |
| WHO-PS, % | ||||||
| 0 | 52 | 36 | 24 | 19 | 15 | 7 |
| 1 | 24 | 46 | 50 | 45 | 23 | 43 |
| 2 | 19 | 14 | 19 | 28 | 28 | 46 |
| 3 | 5 | 4 | 6 | 7 | 23 | 4 |
| 4 | 1 | 0 | 2 | 0 | 7 | 0 |
| Not known | 0 | 0 | 0 | 0 | 4 | 1 |
| Ig heavy chains, % | ||||||
| IgG | 64 | 60 | 67 | 58 | 62 | 68 |
| IgA | 25 | 30 | 21 | 28 | 21 | 15 |
| IgD | 0 | 0 | 0 | 0 | 1 | 3 |
| Light only | 11 | 10 | 10 | 12 | 8 | 2 |
| Other | 0 | 0 | 2 | 0 | 0 | 1 |
| Not known | 0 | 0 | 0 | 2 | 8 | 11 |
| Ig light chains, % | ||||||
| K | 0 | 62 | 65 | 65 | 50 | 52 |
| L | 0 | 38 | 32 | 34 | 31 | 41 |
| Not known | 100 | 0 | 2 | 2 | 19 | 7 |
| Median β2-microglobulin, mg/L | 3.7 | 4.0 | 3.9 | 4.3 | 4.2 | 5.0 |
| Median hemoglobin, g/dL | 10.6 | 10.5 | 10.5 | 10.6 | 10.6 | 9.8 |
| Median albumin, g/L | 36.0 | 34.0 | 38.0 | 38.0 | 33.0 | 36.0 |
| Median creatinine, μM | 70.7 | 96.0 | 92.5 | 90.0 | 94.5 | 97.3 |
| Median LDH, U/L | NR | 293.0 | 337.0 | 331.5 | 223.5 | 238.5 |
| Characteristic . | GIMEMA (n = 331) . | HOVON (n = 333) . | IFM-I (n = 321) . | IFM-II (n = 229) . | NMSG (n = 357) . | TMSG (n = 114) . |
|---|---|---|---|---|---|---|
| Median age, y | 72.5 | 72.6 | 69.4 | 78.5 | 74.4 | 70.6 |
| Sex, % | ||||||
| Male | 54 | 56 | 54 | 45 | 55 | 54 |
| Female | 46 | 44 | 46 | 55 | 45 | 46 |
| DS stage, % | ||||||
| DS I | 0 | 0 | 10 | 9 | 15 | 5 |
| DS II | 38 | 26 | 26 | 23 | 36 | 53 |
| DS III | 62 | 74 | 64 | 68 | 45 | 40 |
| Not known | 0 | 0 | 0 | 0 | 4 | 2 |
| ISS, % | ||||||
| ISS 1 | 19 | 25 | 31 | 22 | 16 | 18 |
| ISS 2 | 38 | 24 | 34 | 38 | 40 | 35 |
| ISS 3 | 23 | 18 | 27 | 28 | 33 | 38 |
| Not known | 20 | 32 | 8 | 12 | 11 | 10 |
| WHO-PS, % | ||||||
| 0 | 52 | 36 | 24 | 19 | 15 | 7 |
| 1 | 24 | 46 | 50 | 45 | 23 | 43 |
| 2 | 19 | 14 | 19 | 28 | 28 | 46 |
| 3 | 5 | 4 | 6 | 7 | 23 | 4 |
| 4 | 1 | 0 | 2 | 0 | 7 | 0 |
| Not known | 0 | 0 | 0 | 0 | 4 | 1 |
| Ig heavy chains, % | ||||||
| IgG | 64 | 60 | 67 | 58 | 62 | 68 |
| IgA | 25 | 30 | 21 | 28 | 21 | 15 |
| IgD | 0 | 0 | 0 | 0 | 1 | 3 |
| Light only | 11 | 10 | 10 | 12 | 8 | 2 |
| Other | 0 | 0 | 2 | 0 | 0 | 1 |
| Not known | 0 | 0 | 0 | 2 | 8 | 11 |
| Ig light chains, % | ||||||
| K | 0 | 62 | 65 | 65 | 50 | 52 |
| L | 0 | 38 | 32 | 34 | 31 | 41 |
| Not known | 100 | 0 | 2 | 2 | 19 | 7 |
| Median β2-microglobulin, mg/L | 3.7 | 4.0 | 3.9 | 4.3 | 4.2 | 5.0 |
| Median hemoglobin, g/dL | 10.6 | 10.5 | 10.5 | 10.6 | 10.6 | 9.8 |
| Median albumin, g/L | 36.0 | 34.0 | 38.0 | 38.0 | 33.0 | 36.0 |
| Median creatinine, μM | 70.7 | 96.0 | 92.5 | 90.0 | 94.5 | 97.3 |
| Median LDH, U/L | NR | 293.0 | 337.0 | 331.5 | 223.5 | 238.5 |
HOVON indicates Hemato-Oncologie voor Volwassenen Nederland; and NR, not recorded.