Comparison of IgD and non-IgD amyloidosis
| . | IgD (n = 53) . | Non-IgD (n = 144) . | P . |
|---|---|---|---|
| Median age, y (IQR) | 60 (50-67) | 61.5 (53-68) | .34 |
| Men, n (%) | 30 (57) | 94 (65) | .31 |
| Hepatomegaly, n (%) | 9 (17) | 39 (27) | .16 |
| Interventricular septal thickness, mm, median (IQR) | 15 (11-17) | 13 (11-15) | .11 |
| Ejection fraction, %, median (IQR) | 60 (44-67) | 60 (50-68) | .17 |
| Creatinine, mg/dL, median (IQR) | 1.1 (0.9-1.6) | 1.1 (0.9-1.5) | .34 |
| Total cholesterol, mg/dL, median (IQR) | 196 (146-299) | 242 (186-328) | .047 |
| β2-microglobulin, μg/mL, median (IQR) | 2.77 (2.15-5.38) | 2.83 (2.07-3.99) | .39 |
| Albumin, g/dL, median (IQR) | 2.97 (2.43-3.54) | 2.69 (2.07-3.37) | .04 |
| Urine protein, g/24 h, median (IQR) | 1.5 (0.3-5.1) | 2.9 (0.4-7.4) | .12 |
| Urine M spike, g/24 h, median (IQR) | 0.28 (0.02-0.63) | 0.19 (0.05-0.69) | .90 |
| Serum M spike | Immunofixation only (fixation only, 0.6 g/dL) | Immunofixation only (fixation only, 0.9 g/dL) | .31 |
| BM plasma cells, %, median (IQR) | 10 (3-30)* | 8 (4-16)† | .09 |
| Renal amyloid, n (%) | 19 (36) | 84 (58) | .005 |
| Cardiac amyloid, n (%) | 24 (45) | 81 (56) | .047 |
| Neuropathy, n (%) | 5 (9) | 19 (13) | .47 |
| Autonomic failure, n (%) | 3 (6) | 10 (7) | .74 |
| . | IgD (n = 53) . | Non-IgD (n = 144) . | P . |
|---|---|---|---|
| Median age, y (IQR) | 60 (50-67) | 61.5 (53-68) | .34 |
| Men, n (%) | 30 (57) | 94 (65) | .31 |
| Hepatomegaly, n (%) | 9 (17) | 39 (27) | .16 |
| Interventricular septal thickness, mm, median (IQR) | 15 (11-17) | 13 (11-15) | .11 |
| Ejection fraction, %, median (IQR) | 60 (44-67) | 60 (50-68) | .17 |
| Creatinine, mg/dL, median (IQR) | 1.1 (0.9-1.6) | 1.1 (0.9-1.5) | .34 |
| Total cholesterol, mg/dL, median (IQR) | 196 (146-299) | 242 (186-328) | .047 |
| β2-microglobulin, μg/mL, median (IQR) | 2.77 (2.15-5.38) | 2.83 (2.07-3.99) | .39 |
| Albumin, g/dL, median (IQR) | 2.97 (2.43-3.54) | 2.69 (2.07-3.37) | .04 |
| Urine protein, g/24 h, median (IQR) | 1.5 (0.3-5.1) | 2.9 (0.4-7.4) | .12 |
| Urine M spike, g/24 h, median (IQR) | 0.28 (0.02-0.63) | 0.19 (0.05-0.69) | .90 |
| Serum M spike | Immunofixation only (fixation only, 0.6 g/dL) | Immunofixation only (fixation only, 0.9 g/dL) | .31 |
| BM plasma cells, %, median (IQR) | 10 (3-30)* | 8 (4-16)† | .09 |
| Renal amyloid, n (%) | 19 (36) | 84 (58) | .005 |
| Cardiac amyloid, n (%) | 24 (45) | 81 (56) | .047 |
| Neuropathy, n (%) | 5 (9) | 19 (13) | .47 |
| Autonomic failure, n (%) | 3 (6) | 10 (7) | .74 |