Summary of IGHV-D-J gene rearrangement, flow cytometry (FC) and immunohistochemistry (IHC) analysis of TCL1tg/tgTIR8−/− mice.
| Animal number . | Age, mo . | % CD19+CD5+ in pb (FC) . | Tissue with clonal rearrangement . | IGHV . | HCDR3 sequence . | Tissue involved by CLL-like (IHC) . | Tissue involved by PLL-like (IHC)* . |
|---|---|---|---|---|---|---|---|
| 209 | 8 | 25.3 | sp | IGHV1-36 | CARGGGNHYAMDYW | sp, lung, kidney, liver | sp, lung, kidney |
| 119 | 9 | 23.8 | sp, bm | IGHV3-3 | CARDTIV#YW | sp, lung | sp, lung |
| 140 | 10 | 42.2 | pb, sp, bm | IGHV3-6 | CARDRDGS##YYAMDYW | sp, lung | sp, lung |
| 193 | 9 | 28.4 | pb, sp, bm | IGHV1-4 | CARGWYYFDYW | sp, lung, liver | sp, lung |
| 145 | 11 | 58.8 | pb, sp, bm | IGHV3-2 | CASSS^LGRGYYFDYW | sp, lung, kidney, liver | sp, lung, kidney |
| 44 | 13 | 17 | pb, sp, bm | IGHV1-26 | CARSDSSDPGGNYW | sp, lung, liver | sp, lung, liver |
| Animal number . | Age, mo . | % CD19+CD5+ in pb (FC) . | Tissue with clonal rearrangement . | IGHV . | HCDR3 sequence . | Tissue involved by CLL-like (IHC) . | Tissue involved by PLL-like (IHC)* . |
|---|---|---|---|---|---|---|---|
| 209 | 8 | 25.3 | sp | IGHV1-36 | CARGGGNHYAMDYW | sp, lung, kidney, liver | sp, lung, kidney |
| 119 | 9 | 23.8 | sp, bm | IGHV3-3 | CARDTIV#YW | sp, lung | sp, lung |
| 140 | 10 | 42.2 | pb, sp, bm | IGHV3-6 | CARDRDGS##YYAMDYW | sp, lung | sp, lung |
| 193 | 9 | 28.4 | pb, sp, bm | IGHV1-4 | CARGWYYFDYW | sp, lung, liver | sp, lung |
| 145 | 11 | 58.8 | pb, sp, bm | IGHV3-2 | CASSS^LGRGYYFDYW | sp, lung, kidney, liver | sp, lung, kidney |
| 44 | 13 | 17 | pb, sp, bm | IGHV1-26 | CARSDSSDPGGNYW | sp, lung, liver | sp, lung, liver |
mo indicates months; pb, peripheral blood; sp, spleen; bm, bone marrow; #, out-of-frame junction; and ̂, stop codon.
No tissues with pure PLL-like component without CLL-like component were registered.