Table 1 Representation of important... | American Society of Hematology

Table 1

Representation of important ubiquitination core enzyme families in the human genome

Protein family	Structural domains	No. of Refseq IDs	No. of HGNC proteins*
E1-activating enzymes	Ubiquitin-activating domain⁴⁰	9	4
E2-conjugating enzymes	UBC core domain⁴¹	78	43
E3 ligases	RING⁴²	562	334
	TRIAD⁴³	33	22
	HECT⁴⁴	45	28
	PHD⁴⁵	290	173
	U box⁴⁶	42	31
E3 complex formation	SOCS box⁴⁷	54	39
Substrate recruitment	F-box⁴⁸	115	72
	BTB⁴⁹	273	188
Proteasome complex		85	68
DUB	UCH, USP, OUT, Josephin, JAMM⁵⁰	98	86

Protein family	Structural domains	No. of Refseq IDs	No. of HGNC proteins*
E1-activating enzymes	Ubiquitin-activating domain⁴⁰	9	4
E2-conjugating enzymes	UBC core domain⁴¹	78	43
E3 ligases	RING⁴²	562	334
	TRIAD⁴³	33	22
	HECT⁴⁴	45	28
	PHD⁴⁵	290	173
	U box⁴⁶	42	31
E3 complex formation	SOCS box⁴⁷	54	39
Substrate recruitment	F-box⁴⁸	115	72
	BTB⁴⁹	273	188
Proteasome complex		85	68
DUB	UCH, USP, OUT, Josephin, JAMM⁵⁰	98	86

DUB indicates deubiquitinating enzyme.

Number of proteins based on protein nomenclature by the HGNC:HUGO Gene Nomenclature Committee.