Table 1 Basic pharmacokinetic parameters... | American Society of Hematology

Table 1

Basic pharmacokinetic parameters for ALX-0081 after single IV administration to cynomolgus monkeys

Dose, mg/kg	AUC_infd, h × kg/mL	CL, mL/h/kg	t_1/2 terminal, h
0.02	0.559 ± 0.192	1.97 ± 0.65	17.0 ± 6.6
0.40	0.085 ± 0.025	13.24 ± 6.11	18.9 ± 6.1
8.00*	0.016 ± 0.004	65.69 ± 15.31	30.2 ± 5.3

Dose, mg/kg	AUC_infd, h × kg/mL	CL, mL/h/kg	t_1/2 terminal, h
0.02	0.559 ± 0.192	1.97 ± 0.65	17.0 ± 6.6
0.40	0.085 ± 0.025	13.24 ± 6.11	18.9 ± 6.1
8.00*	0.016 ± 0.004	65.69 ± 15.31	30.2 ± 5.3

Mean ± SD, n = 6 per dose level. Increase of CL with dose is an artifact of the noncompartmental analysis.

AUC_inf indicates area under the plasma concentration time curve, calculated from 0 to infinity; D, dose; and CL, clearance.

One animal was considered an outlier due to a nondecreasing profile and was therefore excluded from the analysis (n = 5).