Table 3

Treatment and outcome of secondary AD in all patients having received autologous HSCT for a primary AD

Original ADSecondary ADNo. of patientsTreatment of ADStatus of secondary AD at last follow-up
SLE AIHA Prednisone, cyclophosphamide, rituximab Resolved 
SSc AIHA None Resolved 
MS Hemophilia Prednisone, cyclophosphamide, IVIg, RTX, novo 7 Dead 
MS Hemophilia Prednisone, cyclophosphamide, cyclosporine, IVIg, PE Resolved 
SLE Hemophilia Prednisone, cyclophosphamide, IVIg, PE, RTX Resolved 
SSc ITP Prednisone Resolved 
MS ITP Prednisone Resolved 
MS ITP/AIHA Prednisone, MMF, IVIg, rituximab Ongoing with therapy until dead (HSCT related) 
1 SLE/1 SSc Antiphospholipid syndrome Steroids/none Resolved/dead 
1 JIA Thyroiditis Unknown Unknown 
1 JIA/1 IDD Thyroiditis None/L-thyroxine Ongoing without treatment 
1 SSc, 3 MS 1 JIA, 1 SLE Thyroiditis L-thyroxine or thyrostatic therapy Ongoing with therapy 
1 MS Thyroiditis L-thyroxine Resolved 
SSc Blocking TSHR antibody None Ongoing without therapy 
SSc Graves disease Carbimazole Ongoing with therapy 
SLE Graves disease Thyroidectomy Resolved 
SSc Myasthenia gravis MMF Ongoing with therapy 
SSc Rheumatoid arthritis Methotrexate, abatacept Ongoing with therapy 
SSc Rheumatoid arthritis NSAIDs Ongoing without therapy 
JIA Sarcoidosis Prednisone, methotrexate Ongoing with therapy 
JIA Sarcoidosis Prednisone Resolved 
RA Psoriasis None Ongoing without therapy 
Original ADSecondary ADNo. of patientsTreatment of ADStatus of secondary AD at last follow-up
SLE AIHA Prednisone, cyclophosphamide, rituximab Resolved 
SSc AIHA None Resolved 
MS Hemophilia Prednisone, cyclophosphamide, IVIg, RTX, novo 7 Dead 
MS Hemophilia Prednisone, cyclophosphamide, cyclosporine, IVIg, PE Resolved 
SLE Hemophilia Prednisone, cyclophosphamide, IVIg, PE, RTX Resolved 
SSc ITP Prednisone Resolved 
MS ITP Prednisone Resolved 
MS ITP/AIHA Prednisone, MMF, IVIg, rituximab Ongoing with therapy until dead (HSCT related) 
1 SLE/1 SSc Antiphospholipid syndrome Steroids/none Resolved/dead 
1 JIA Thyroiditis Unknown Unknown 
1 JIA/1 IDD Thyroiditis None/L-thyroxine Ongoing without treatment 
1 SSc, 3 MS 1 JIA, 1 SLE Thyroiditis L-thyroxine or thyrostatic therapy Ongoing with therapy 
1 MS Thyroiditis L-thyroxine Resolved 
SSc Blocking TSHR antibody None Ongoing without therapy 
SSc Graves disease Carbimazole Ongoing with therapy 
SLE Graves disease Thyroidectomy Resolved 
SSc Myasthenia gravis MMF Ongoing with therapy 
SSc Rheumatoid arthritis Methotrexate, abatacept Ongoing with therapy 
SSc Rheumatoid arthritis NSAIDs Ongoing without therapy 
JIA Sarcoidosis Prednisone, methotrexate Ongoing with therapy 
JIA Sarcoidosis Prednisone Resolved 
RA Psoriasis None Ongoing without therapy 

MMF indicates mycophenolate mofetil; IVIg, intravenous immunoglobulin; PE, plasma exchange; NSAIDs, nonsteroidal anti-inflammatory drugs; RTX, rituximab; TSHR, thyroid stimulating hormone receptor; MS, multiple sclerosis; SSc, systemic sclerosis; and JIA, juvenile idiopathic arthritis.

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