Age-adjusted IRs and IRRs of AML, ALL/L, and AL of ambiguous lineage according to subtype and sex, SEER-17, 2001 to 2007
. | Total . | Male . | Female . | Male-to-female . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
No. . | % . | IR . | Median age, y . | No. . | IR . | No. . | IR . | IRR . | 95% CI . | |
AML* | 19 497 | 100 | 38.0 | 66 | 10 590 | 46.8 | 8 907 | 31.6 | 1.48 | 1.44-1.52 |
Subtype | ||||||||||
Group 1 | 15 764 | 80.9 | 30.8 | 67 | 8 580 | 38.3 | 7 184 | 25.4 | 1.51 | 1.46-1.55 |
AML, NOS; [M-9861] | 8 559 | 43.9 | 16.8 | 70 | 4 689 | 21.3 | 3 870 | 13.6 | 1.57 | 1.50-1.64 |
AML with minimal differentiation; (FAB M0) [M-9872] | 770 | 3.9 | 1.5 | 67 | 432 | 1.9 | 338 | 1.2 | 1.60 | 1.38-1.85 |
AML without maturation; (FAB M1) [M-9873] | 1 081 | 5.5 | 2.1 | 63 | 566 | 2.4 | 515 | 1.9 | 1.32 | 1.17-1.49 |
AML with maturation; (FAB M2) [M-9874] | 1 254 | 6.4 | 2.4 | 66 | 647 | 2.9 | 607 | 2.2 | 1.33 | 1.19-1.49 |
Acute myelomonocytic leukemia; (FAB M4) [M-9867] | 1 771 | 9.1 | 3.4 | 64 | 976 | 4.2 | 795 | 2.8 | 1.50 | 1.36-1.65 |
Acute monoblastic and monocytic leukemia; (FAB M5) [M-9891] | 1 465 | 7.5 | 2.8 | 62 | 769 | 3.3 | 696 | 2.5 | 1.34 | 1.20-1.48 |
Acute erythroid leukemia; (FAB M6) [M-9840] | 344 | 1.8 | 0.7 | 68 | 213 | 1.0 | 131 | 0.5 | 2.05 | 1.64-2.57 |
Acute megakaryoblastic leukemia; (FAB M7) [M-9910] | 209 | 1.1 | 0.4 | 39 | 113 | 0.5 | 96 | 0.4 | 1.32 | 1.00-1.76 |
Acute basophilic leukemia; [M-9870] | 5 | < 0.1 | ∼ | 71 | 2 | ∼ | 3 | ∼ | ∼ | |
Acute panmyelosis with myelofibrosis; [M-9931] | 133 | 0.7 | 0.3 | 67 | 71 | 0.3 | 62 | 0.2 | 1.39 | 0.97-2.00 |
Myeloid sarcoma; [M-9930] | 173 | 0.9 | 0.3 | 59 | 102 | 0.4 | 71 | 0.3 | 1.67 | 1.22-2.30 |
Group 2 | 2 089 | 10.7 | 4.0 | 48 | 1 075 | 4.3 | 1 014 | 3.7 | 1.16 | 1.06-1.27 |
AML with t(8;21); (FAB M2, t(8;21)) [M-9896] | 313 | 1.6 | 0.6 | 52 | 178 | 0.7 | 135 | 0.5 | 1.49 | 1.18-1.88 |
AML with inv(16) or t(16;16); (FAB M4Eo) [M-9871] | 203 | 1.0 | 0.4 | 47 | 109 | 0.4 | 94 | 0.3 | 1.26 | 0.94-1.68 |
APL with t(15;17); (FAB M3) [M-9866] | 1 440 | 7.4 | 2.7 | 47 | 721 | 2.9 | 719 | 2.6 | 1.08 | 0.97-1.20 |
AML, 11q23 abnormalities; [M-9897] | 133 | 0.7 | 0.3 | 61 | 67 | 0.3 | 66 | 0.2 | 1.24 | 0.87-1.77 |
Group 3 | 1 644 | 8.4 | 3.2 | 69 | 935 | 4.2 | 709 | 2.5 | 1.69 | 1.53-1.87 |
AML with myelodysplasia-related changes; [M-9895] | 1 191 | 6.1 | 2.4 | 71 | 731 | 3.4 | 460 | 1.6 | 2.08 | 1.84-2.34 |
Therapy-related myeloid neoplasms; [M-9920, 9987] | 453 | 2.3 | 0.9 | 63 | 204 | 0.9 | 249 | 0.9 | 0.99 | 0.82-1.20 |
ALL/L* | 9 188 | 100 | 17.3 | 14 | 5 248 | 19.7 | 3 940 | 14.8 | 1.33 | 1.28-1.39 |
Subtype | ||||||||||
B-cell lymphoblastic leukemia/lymphoma; [M-9727(B), 9728, 9835(B), 9836] | 6 213 | 67.6 | 11.7 | 12 | 3 392 | 12.7 | 2 821 | 10.6 | 1.20 | 1.14-1.26 |
T-cell lymphoblastic leukemia/lymphoma; [M-9727(T), 9729, 9835(T), 9837] | 1 396 | 15.2 | 2.6 | 18 | 965 | 3.6 | 431 | 1.6 | 2.20 | 1.96-2.47 |
Lymphoblastic leukemia/lymphoma, unknown lineage; [M-9727(U), 9835(U)] | 1 579 | 17.2 | 3.0 | 12 | 891 | 3.4 | 688 | 2.6 | 1.34 | 1.21-1.48 |
AL of ambiguous lineage* | 997 | 100 | 2.0 | 73 | 546 | 2.5 | 451 | 1.6 | 1.63 | 1.43-1.85 |
Subtype | ||||||||||
Acute undifferentiated leukemia; [M-9801] | 825 | 82.7 | 1.6 | 75 | 443 | 2.1 | 382 | 1.3 | 1.61 | 1.40-1.86 |
Acute biphenotypic leukemia; [M-9805] | 172 | 17.3 | 0.3 | 53 | 103 | 0.4 | 69 | 0.3 | 1.71 | 1.24-2.36 |
. | Total . | Male . | Female . | Male-to-female . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
No. . | % . | IR . | Median age, y . | No. . | IR . | No. . | IR . | IRR . | 95% CI . | |
AML* | 19 497 | 100 | 38.0 | 66 | 10 590 | 46.8 | 8 907 | 31.6 | 1.48 | 1.44-1.52 |
Subtype | ||||||||||
Group 1 | 15 764 | 80.9 | 30.8 | 67 | 8 580 | 38.3 | 7 184 | 25.4 | 1.51 | 1.46-1.55 |
AML, NOS; [M-9861] | 8 559 | 43.9 | 16.8 | 70 | 4 689 | 21.3 | 3 870 | 13.6 | 1.57 | 1.50-1.64 |
AML with minimal differentiation; (FAB M0) [M-9872] | 770 | 3.9 | 1.5 | 67 | 432 | 1.9 | 338 | 1.2 | 1.60 | 1.38-1.85 |
AML without maturation; (FAB M1) [M-9873] | 1 081 | 5.5 | 2.1 | 63 | 566 | 2.4 | 515 | 1.9 | 1.32 | 1.17-1.49 |
AML with maturation; (FAB M2) [M-9874] | 1 254 | 6.4 | 2.4 | 66 | 647 | 2.9 | 607 | 2.2 | 1.33 | 1.19-1.49 |
Acute myelomonocytic leukemia; (FAB M4) [M-9867] | 1 771 | 9.1 | 3.4 | 64 | 976 | 4.2 | 795 | 2.8 | 1.50 | 1.36-1.65 |
Acute monoblastic and monocytic leukemia; (FAB M5) [M-9891] | 1 465 | 7.5 | 2.8 | 62 | 769 | 3.3 | 696 | 2.5 | 1.34 | 1.20-1.48 |
Acute erythroid leukemia; (FAB M6) [M-9840] | 344 | 1.8 | 0.7 | 68 | 213 | 1.0 | 131 | 0.5 | 2.05 | 1.64-2.57 |
Acute megakaryoblastic leukemia; (FAB M7) [M-9910] | 209 | 1.1 | 0.4 | 39 | 113 | 0.5 | 96 | 0.4 | 1.32 | 1.00-1.76 |
Acute basophilic leukemia; [M-9870] | 5 | < 0.1 | ∼ | 71 | 2 | ∼ | 3 | ∼ | ∼ | |
Acute panmyelosis with myelofibrosis; [M-9931] | 133 | 0.7 | 0.3 | 67 | 71 | 0.3 | 62 | 0.2 | 1.39 | 0.97-2.00 |
Myeloid sarcoma; [M-9930] | 173 | 0.9 | 0.3 | 59 | 102 | 0.4 | 71 | 0.3 | 1.67 | 1.22-2.30 |
Group 2 | 2 089 | 10.7 | 4.0 | 48 | 1 075 | 4.3 | 1 014 | 3.7 | 1.16 | 1.06-1.27 |
AML with t(8;21); (FAB M2, t(8;21)) [M-9896] | 313 | 1.6 | 0.6 | 52 | 178 | 0.7 | 135 | 0.5 | 1.49 | 1.18-1.88 |
AML with inv(16) or t(16;16); (FAB M4Eo) [M-9871] | 203 | 1.0 | 0.4 | 47 | 109 | 0.4 | 94 | 0.3 | 1.26 | 0.94-1.68 |
APL with t(15;17); (FAB M3) [M-9866] | 1 440 | 7.4 | 2.7 | 47 | 721 | 2.9 | 719 | 2.6 | 1.08 | 0.97-1.20 |
AML, 11q23 abnormalities; [M-9897] | 133 | 0.7 | 0.3 | 61 | 67 | 0.3 | 66 | 0.2 | 1.24 | 0.87-1.77 |
Group 3 | 1 644 | 8.4 | 3.2 | 69 | 935 | 4.2 | 709 | 2.5 | 1.69 | 1.53-1.87 |
AML with myelodysplasia-related changes; [M-9895] | 1 191 | 6.1 | 2.4 | 71 | 731 | 3.4 | 460 | 1.6 | 2.08 | 1.84-2.34 |
Therapy-related myeloid neoplasms; [M-9920, 9987] | 453 | 2.3 | 0.9 | 63 | 204 | 0.9 | 249 | 0.9 | 0.99 | 0.82-1.20 |
ALL/L* | 9 188 | 100 | 17.3 | 14 | 5 248 | 19.7 | 3 940 | 14.8 | 1.33 | 1.28-1.39 |
Subtype | ||||||||||
B-cell lymphoblastic leukemia/lymphoma; [M-9727(B), 9728, 9835(B), 9836] | 6 213 | 67.6 | 11.7 | 12 | 3 392 | 12.7 | 2 821 | 10.6 | 1.20 | 1.14-1.26 |
T-cell lymphoblastic leukemia/lymphoma; [M-9727(T), 9729, 9835(T), 9837] | 1 396 | 15.2 | 2.6 | 18 | 965 | 3.6 | 431 | 1.6 | 2.20 | 1.96-2.47 |
Lymphoblastic leukemia/lymphoma, unknown lineage; [M-9727(U), 9835(U)] | 1 579 | 17.2 | 3.0 | 12 | 891 | 3.4 | 688 | 2.6 | 1.34 | 1.21-1.48 |
AL of ambiguous lineage* | 997 | 100 | 2.0 | 73 | 546 | 2.5 | 451 | 1.6 | 1.63 | 1.43-1.85 |
Subtype | ||||||||||
Acute undifferentiated leukemia; [M-9801] | 825 | 82.7 | 1.6 | 75 | 443 | 2.1 | 382 | 1.3 | 1.61 | 1.40-1.86 |
Acute biphenotypic leukemia; [M-9805] | 172 | 17.3 | 0.3 | 53 | 103 | 0.4 | 69 | 0.3 | 1.71 | 1.24-2.36 |
All incidence rates are age-adjusted to the 2000 US standard population and expressed per 1 000 000 person-years. Incidence rate ratios are based on unrounded rates.
FAB indicates French-American-British classification; (B), B-cell immunophenotype; (T), T-cell immunophenotype; (U), immunophenotype not specified; and ∼, IRs not calculated for fewer than 10 cases.
Includes all ICD-O-3 morphology codes specified within the respective subtype categories. ICD-O-3 codes are specified within brackets.