Patient characteristics
Number of study patients | 71 |
Median age, y (range) | 8.0 (0.6-23.1) |
Median follow-up after transplantation, y (range) | 1.5 (0.1-4.3) |
Disease status xabefore transplantation, n | |
CR1 | 23 |
CR2 | 29 |
CR > 2 | 2 |
NR | 17 |
Donor, n | |
MSD | 23 |
MUD | 31 |
MMFD | 17 |
Stem-cell source, n | |
BM | 45 |
PB | 23 |
Other | 3 |
T-cell depletion, n | |
Yes | 15 |
No | 56 |
Myeloablative conditioning regimen, n | |
Busulfan-based | |
Bus + Cyc + Mel ± ATG, n | 34 |
Bus + Cyc ± ATG | 9 |
Other (TBI/treosulfan-based) | 4 |
RIC, n | |
Flu + Thio + Mel + OKT3 | 12 |
TBI (4 Gy) + Amsa + Flu + Cyt ± Cyc ± Bus ± ATG | 7 |
Other | 5 |
Number of study patients | 71 |
Median age, y (range) | 8.0 (0.6-23.1) |
Median follow-up after transplantation, y (range) | 1.5 (0.1-4.3) |
Disease status xabefore transplantation, n | |
CR1 | 23 |
CR2 | 29 |
CR > 2 | 2 |
NR | 17 |
Donor, n | |
MSD | 23 |
MUD | 31 |
MMFD | 17 |
Stem-cell source, n | |
BM | 45 |
PB | 23 |
Other | 3 |
T-cell depletion, n | |
Yes | 15 |
No | 56 |
Myeloablative conditioning regimen, n | |
Busulfan-based | |
Bus + Cyc + Mel ± ATG, n | 34 |
Bus + Cyc ± ATG | 9 |
Other (TBI/treosulfan-based) | 4 |
RIC, n | |
Flu + Thio + Mel + OKT3 | 12 |
TBI (4 Gy) + Amsa + Flu + Cyt ± Cyc ± Bus ± ATG | 7 |
Other | 5 |
Amsa indicates amsacrine; ATG, antithymocyte globulin; Bus, busulfan; Cyc, cyclophosphamide; Cyt, cytarabine; Flu, fludarabine; OKT3, anti-CD3 mAb; Mel, melphalan; TBI, total body irradiation; and Thio, thiotepa.