Hematopoietic parameters and organ weight in Dmtf1-mutant mice
| . | WT . | KO . | Het . |
|---|---|---|---|
| PB count at 13 wk of age, /μL | |||
| WBCs | 16 829 ± 6338 | 21 418 ± 7365 | 16 826 ± 5163 |
| Neutrophils | 4211 ± 1672 | 4593 ± 2906 | 3647 ± 1366 |
| Lymphocytes | 11 617 ± 4679*** | 15 160 ± 4647### | 11 957 ± 3938 |
| Monocytes | 777 ± 427** | 1327 ± 552## | 964 ± 419 |
| RBCs, × 104/μL | 114 ± 9.1* | 129 ± 13.3# | 115 ± 7.3 |
| Hemoglobin, g/dL | 15.8 ± 1.9* | 18.7 ± 1.6# | 16.3 ± 1.2 |
| Hematocrit, % | 51.3 ± 4.2* | 58.9 ± 6.8# | 51.7 ± 3.1 |
| Platelets, × 104/μL | 997.6 ± 292.1 | 1018.8 ± 138.2 | 1052.1 ± 222.3 |
| Distribution of WBCs, % | |||
| CD4 | 20.9 ± 4.94*** | 16.2 ± 3.71 | 18.4 ± 5.51 |
| CD8 | 15.6 ± 3.34*** | 12.6 ± 2.97 | 13.4 ± 3.09 |
| B220 | 41.6 ± 9.19 | 45.7 ± 8.51 | 43.9 ± 9.99 |
| Myeloid | 21.6 ± 4.94 | 24.6 ± 4.52 | 22.1 ± 5.98 |
| BM count at 13 wk of age, × 107/2 femurs | 4.94 ± 0.9* | 6.75 ± 0.8# | 5.35 ± 0.6 |
| Myeloid, % | 80.81 ± 7.23 | 74.25 ± 6.50 | |
| B220, % | 13.28 ± 4.11** | 20.03 ± 3.61 | |
| CD3, % | 2.01 ± 0.57 | 2.18 ± 0.65 | |
| Weights | |||
| Body weight at 13 wk of age, g | 27.9 ± 1.8* | 24.5 ± 1.1# | 27.5 ± 2.1 |
| Spleen weight at 14 wk of age, mg | 98.4 ± 16.1 | 88.4 ± 15.4 | 92.1 ± 14.5 |
| Thymus weight at 14 wk of age, mg | 59.6 ± 9.4* | 34.8 ± 9.5# | 56.3 ± 12.7 |
| . | WT . | KO . | Het . |
|---|---|---|---|
| PB count at 13 wk of age, /μL | |||
| WBCs | 16 829 ± 6338 | 21 418 ± 7365 | 16 826 ± 5163 |
| Neutrophils | 4211 ± 1672 | 4593 ± 2906 | 3647 ± 1366 |
| Lymphocytes | 11 617 ± 4679*** | 15 160 ± 4647### | 11 957 ± 3938 |
| Monocytes | 777 ± 427** | 1327 ± 552## | 964 ± 419 |
| RBCs, × 104/μL | 114 ± 9.1* | 129 ± 13.3# | 115 ± 7.3 |
| Hemoglobin, g/dL | 15.8 ± 1.9* | 18.7 ± 1.6# | 16.3 ± 1.2 |
| Hematocrit, % | 51.3 ± 4.2* | 58.9 ± 6.8# | 51.7 ± 3.1 |
| Platelets, × 104/μL | 997.6 ± 292.1 | 1018.8 ± 138.2 | 1052.1 ± 222.3 |
| Distribution of WBCs, % | |||
| CD4 | 20.9 ± 4.94*** | 16.2 ± 3.71 | 18.4 ± 5.51 |
| CD8 | 15.6 ± 3.34*** | 12.6 ± 2.97 | 13.4 ± 3.09 |
| B220 | 41.6 ± 9.19 | 45.7 ± 8.51 | 43.9 ± 9.99 |
| Myeloid | 21.6 ± 4.94 | 24.6 ± 4.52 | 22.1 ± 5.98 |
| BM count at 13 wk of age, × 107/2 femurs | 4.94 ± 0.9* | 6.75 ± 0.8# | 5.35 ± 0.6 |
| Myeloid, % | 80.81 ± 7.23 | 74.25 ± 6.50 | |
| B220, % | 13.28 ± 4.11** | 20.03 ± 3.61 | |
| CD3, % | 2.01 ± 0.57 | 2.18 ± 0.65 | |
| Weights | |||
| Body weight at 13 wk of age, g | 27.9 ± 1.8* | 24.5 ± 1.1# | 27.5 ± 2.1 |
| Spleen weight at 14 wk of age, mg | 98.4 ± 16.1 | 88.4 ± 15.4 | 92.1 ± 14.5 |
| Thymus weight at 14 wk of age, mg | 59.6 ± 9.4* | 34.8 ± 9.5# | 56.3 ± 12.7 |
Values shown are the means ± SD (all male). PB counts are for 18-20 mice per genotype; BM cell counts are for 10-14 mice per genotype; body weights are for 10-15 mice per genotype; and spleen/thymus weights are for 7-9 mice per genotype.
* and # indicate significant statistical differences between WT and KO and KO and Het, respectively. */#P < .01, **/##P < .03, and ***/###P < .05.