CLL-like clones molecular parameters
ID . | Sex . | Age, y . | Follow-up, mo . | Clone, cells/μL . | Light chain . | FISH . | IGHV gene . | IGHV identity, % . | T-cell clones . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First visit . | Follow-up . | CD4+ . | CD8+ . | CD4highCD8low . | CD4lowCD8high . | ||||||||
VB0010 | F | 65 | 50 | 5.35 | 6.10 | κ | ND | IGHV3-30 | 97.7 | No clones | No clones | TRBV3 = 22.4% TRBV7.1 = 22.4% TRBV8 = 33.9% TRBV13.6 = 32.1% | No clones |
VB0094* | M | 73 | 48 | 16.11 | 1.63 | κ | Normal | IGHV4-59/-61 | 95.6 | No clones | No clones | TRBV8 = 23.1% | No clones |
VB0106 | M | 83 | 48 | 1.03 | 0.35 | λ | ND | IGHV3-30 | 97.8 | ND | ND | ND | ND |
VB0266 | M | 74 | 47 | 6.56 | 8.16 | κ | ND | IGHV3-21 | 89.1 | No clones | No clones | TRBV2 = 25.3% TRBV8 = 27.4% | No clones |
VB0274 | F | 67 | 47 | 7.26 | 11.26 | κ | ND | IGHV4-59/-61 | 95.0 | No clones | TRBV9 = 55.0% | No clones | No clones |
VB0314 | F | 78 | 47 | 5.79 | 4.82 | λ | Del13q14.3† (19%), trisomy 12 (28%) | IGHV4-59/-61 | 94.4 | No clones | No clones | No clones | No clones |
VB0323 | M | 75 | 47 | 0.51 | 0.61 | κ | ND | IGHV4-34 | 97.7 | ND | ND | ND | ND |
VB0399 | M | 66 | 46 | 0.74 | 0.22 | κ | ND | IGHV3-48 | 93.9 | No clones | No clones | No clones | TRBV17 = 21.4% |
VB0400 | M | 65 | 46 | 0.61 | 0.32 | κ | ND | IGHV3-64 | 86.8 | No clones | No clones | No clones | TRBV2 = 22.2% |
VB0457 | F | 83 | 46 | 0.44 | 2.22 | κ | Normal | IGHV3-23 | 100.0 | No clones | TRBV8 = 28.4% | TRBV2 = 21.1% | TRBV22 = 21.4% |
VB0537 | M | 74 | 47 | 1.79 | 0.75 | κ | ND | IGHV3-30 | 97.5 | ND | ND | ND | ND |
VB0588 | F | 65 | 39 | 96.73 | 319.10 | κ | Del13q14.3 (31%) | IGHV4-59 | 93.5 | No clones | No clones | TRBV5.2 = 21.5% | No clones |
VB0643 | M | 40 | 39 | 0.88 | 0.61 | κ | ND | IGHV3-64 | 93.9 | No clones | No clones | TRBV22 = 50.8% | No clones |
VB0656 | M | 49 | 39 | 0.88 | 0.46 | κ | ND | IGHV3-7 | 97.0 | No clones | No clones | No clones | No clones |
VB0667 | M | 65 | 38 | 0.24 | 0.68 | κ | Normal | ND | ND | No clones | No clones | No clones | TRBV22 = 26.1% |
VB0670 | M | 68 | 37 | 0.24 | 0.21 | κ | ND | ND | ND | ND | ND | ND | ND |
VB0679 | M | 67 | 38 | 6.34 | 9.25 | λ | ND | IGHV4-59/-61 | 89.4 | No clones | No clones | TRBV7.2 = 39.4% TRBV8 = 30.1% | No clones |
VB0689 | M | 60 | 38 | 221.33 | 247.09 | κ | Normal | IGHV3-73 | 92.6 | No clones | No clones | TRBV2 = 25.7% | No clones |
VB0777 | M | 68 | 37 | 0.66 | 0.79 | κ | ND | ND | ND | ND | ND | ND | ND |
VB0790 | F | 61 | 36 | 1.50 | 13.55 | κ | Normal | IGHV4-30-4 | 94.4 | No clones | No clones | No clones | TRBV13.1 = 48.1% |
VB0819 | M | 85 | 37 | 0.19 | 0.46 | κ | ND | IGHV3-48 | 88.3 | ND | ND | ND | ND |
VB0902 | M | 69 | 36 | 0.96 | 6.76 | κ | Normal | IGHV4-39 | 100.0 | No clones | TRBV2 = 35.7% | No clones | No clones |
VB1002 | F | 63 | 35 | 1.67 | 1.60 | κ | Del17p (80%) | IGHV4-59/-61 | 97.0 | No clones | No clones | TRBV9 = 24.8% TRBV16 = 38.9% | TRBV5.3 = 32.6% TRBV16 = 38.3% |
VB1091 | F | 46 | 35 | 1.12 | 1.61 | Polyclonal | ND | IGHV3-15 | 93.5 | No clones | TRBV18 = 37.5% | TRBV2 = 30.2% TRBV8 = 19.4% | No clones |
VB1134 | M | 58 | 34 | 2.36 | 0.46 | κ | Del13q34 (25%) | ND | ND | No clones | No clones | No clones | TRBV13.6 = 22.2% |
VB1135 | M | 62 | 35 | 0.35 | 0.35 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1170 | F | 58 | 34 | 0.85 | 0.33 | κ | ND | ND | ND | No clones | No clones | TRBV2 = 30.2% TRBV17 = 21.1% | TRBV2 = 25.0% TRBV22 = 21.7% |
VB1189 | M | 80 | 34 | 189.76 | 399.29 | κ | Normal | IGHV3-21 | 88.2 | No clones | TRBV8 = 23.1% | TRVB13.6 = 42.8% | No clones |
VB1202 | F | 61 | 34 | 4.72 | 18.56 | κ | Del13q14.3 (48%) | ND | ND | No clones | No clones | No clones | No clones |
VB1231 | F | 64 | 35 | 50.38 | 50.59 | κ | ND | IGHV3-64 | 100.0 | No clones | No clones | No clones | TRBV1 = 22.7% |
VB1239 | M | 75 | 34 | 0.41 | 0.50 | κ | ND | IGHV3-23 | 92.0 | ND | ND | ND | ND |
VB1240 | F | 84 | 31 | 1763.90 | 1249.29 | λ | Normal | IGHV3-15 | 98.3 | No clones | No clones | No clones | No clones |
VB1309 | M | 59 | 24 | 0.50 | 0.56 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1320 | F | 61 | 24 | 0.41 | 3.82 | λ | Del13q14.3-q34 (25% and 30%), Del17p (90%) | ND | ND | No clones | No clones | TRBV5.3 = 35.7% TRBV8 = 48.4% TRBV17 = 33.8% | TRBV16 = 32.1% |
VB1349 | M | 72 | 24 | 0.75 | 1.11 | κ | ND | ND | ND | No clones | TRBV1 = 61.5% | No clones | TRBV17 = 21.4% |
VB1377 | M | 68 | 24 | 3.78 | 2.42 | κ | Del13q34 (28%) | ND | ND | No clones | No clones | No clones | No clones |
VB1378 | F | 77 | 25 | 0.54 | 0.42 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1393 | F | 75 | 25 | 0.55 | 1.84 | κ | ND | ND | ND | No clones | TRBV13.2 = 25.8% | No clones | No clones |
VB1395 | F | 76 | 25 | 1.53 | 1.22 | Polyclonal | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1451 | F | 66 | 23 | 0.46 | 2.36 | κ | ND | ND | ND | No clones | No clones | TRBV2 = 45.7% | No clones |
VB1470 | F | 73 | 23 | 0.94 | 4.02 | κ | Del13q14.3† (37%) | ND | ND | No clones | TRBV13.2 = 38.3% | TRBV16 = 40.3% TRBV21.3 = 42.1% | No clones |
VB1484 | M | 64 | 24 | 0.25 | 0.73 | Polyclonal | ND | ND | ND | ND | ND | ND | ND |
VB1487 | M | 84 | 23 | 0.06 | 0.53 | κ | ND | IGHV4-59/-61 | 94.1 | No clones | No clones | No clones | TRBV7.1 = 46.4% TRBV8 = 29.4% TRBV17 = 26.9% TRBV22 = 28.6% |
VB1518 | M | 53 | 22 | 1.21 | 1.16 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1523 | M | 60 | 22 | 0.84 | 1.54 | Polyclonal | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1531 | M | 61 | 23 | 0.50 | 0.75 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1592 | F | 92 | 21 | 0.29 | 0.20 | Polyclonal | ND | IGHV3-64 | 98.1 | ND | ND | ND | ND |
VB1646 | M | 62 | 22 | 9.03 | 4.84 | Negative | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1686 | M | 83 | 22 | 0.96 | 1.31 | κ | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1688 | M | 55 | 21 | 1.22 | 1.07 | Polyclonal | ND | IGHV3-21 | 95.1 | ND | ND | ND | ND |
VB1698 | M | 48 | 21 | 264.98 | 336.74 | λ | ND | IGHV3-15 | 93.0 | No clones | No clones | TRBV2 = 42.2% | TRBV17 = 42.2% |
VB1711 | F | 56 | 11 | 0.41 | 0.32 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1712 | M | 72 | 11 | 0.35 | 1.53 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1736 | M | 48 | 11 | 0.68 | 0.26 | Kappa | ND | ND | ND | ND | ND | ND | ND |
ID . | Sex . | Age, y . | Follow-up, mo . | Clone, cells/μL . | Light chain . | FISH . | IGHV gene . | IGHV identity, % . | T-cell clones . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First visit . | Follow-up . | CD4+ . | CD8+ . | CD4highCD8low . | CD4lowCD8high . | ||||||||
VB0010 | F | 65 | 50 | 5.35 | 6.10 | κ | ND | IGHV3-30 | 97.7 | No clones | No clones | TRBV3 = 22.4% TRBV7.1 = 22.4% TRBV8 = 33.9% TRBV13.6 = 32.1% | No clones |
VB0094* | M | 73 | 48 | 16.11 | 1.63 | κ | Normal | IGHV4-59/-61 | 95.6 | No clones | No clones | TRBV8 = 23.1% | No clones |
VB0106 | M | 83 | 48 | 1.03 | 0.35 | λ | ND | IGHV3-30 | 97.8 | ND | ND | ND | ND |
VB0266 | M | 74 | 47 | 6.56 | 8.16 | κ | ND | IGHV3-21 | 89.1 | No clones | No clones | TRBV2 = 25.3% TRBV8 = 27.4% | No clones |
VB0274 | F | 67 | 47 | 7.26 | 11.26 | κ | ND | IGHV4-59/-61 | 95.0 | No clones | TRBV9 = 55.0% | No clones | No clones |
VB0314 | F | 78 | 47 | 5.79 | 4.82 | λ | Del13q14.3† (19%), trisomy 12 (28%) | IGHV4-59/-61 | 94.4 | No clones | No clones | No clones | No clones |
VB0323 | M | 75 | 47 | 0.51 | 0.61 | κ | ND | IGHV4-34 | 97.7 | ND | ND | ND | ND |
VB0399 | M | 66 | 46 | 0.74 | 0.22 | κ | ND | IGHV3-48 | 93.9 | No clones | No clones | No clones | TRBV17 = 21.4% |
VB0400 | M | 65 | 46 | 0.61 | 0.32 | κ | ND | IGHV3-64 | 86.8 | No clones | No clones | No clones | TRBV2 = 22.2% |
VB0457 | F | 83 | 46 | 0.44 | 2.22 | κ | Normal | IGHV3-23 | 100.0 | No clones | TRBV8 = 28.4% | TRBV2 = 21.1% | TRBV22 = 21.4% |
VB0537 | M | 74 | 47 | 1.79 | 0.75 | κ | ND | IGHV3-30 | 97.5 | ND | ND | ND | ND |
VB0588 | F | 65 | 39 | 96.73 | 319.10 | κ | Del13q14.3 (31%) | IGHV4-59 | 93.5 | No clones | No clones | TRBV5.2 = 21.5% | No clones |
VB0643 | M | 40 | 39 | 0.88 | 0.61 | κ | ND | IGHV3-64 | 93.9 | No clones | No clones | TRBV22 = 50.8% | No clones |
VB0656 | M | 49 | 39 | 0.88 | 0.46 | κ | ND | IGHV3-7 | 97.0 | No clones | No clones | No clones | No clones |
VB0667 | M | 65 | 38 | 0.24 | 0.68 | κ | Normal | ND | ND | No clones | No clones | No clones | TRBV22 = 26.1% |
VB0670 | M | 68 | 37 | 0.24 | 0.21 | κ | ND | ND | ND | ND | ND | ND | ND |
VB0679 | M | 67 | 38 | 6.34 | 9.25 | λ | ND | IGHV4-59/-61 | 89.4 | No clones | No clones | TRBV7.2 = 39.4% TRBV8 = 30.1% | No clones |
VB0689 | M | 60 | 38 | 221.33 | 247.09 | κ | Normal | IGHV3-73 | 92.6 | No clones | No clones | TRBV2 = 25.7% | No clones |
VB0777 | M | 68 | 37 | 0.66 | 0.79 | κ | ND | ND | ND | ND | ND | ND | ND |
VB0790 | F | 61 | 36 | 1.50 | 13.55 | κ | Normal | IGHV4-30-4 | 94.4 | No clones | No clones | No clones | TRBV13.1 = 48.1% |
VB0819 | M | 85 | 37 | 0.19 | 0.46 | κ | ND | IGHV3-48 | 88.3 | ND | ND | ND | ND |
VB0902 | M | 69 | 36 | 0.96 | 6.76 | κ | Normal | IGHV4-39 | 100.0 | No clones | TRBV2 = 35.7% | No clones | No clones |
VB1002 | F | 63 | 35 | 1.67 | 1.60 | κ | Del17p (80%) | IGHV4-59/-61 | 97.0 | No clones | No clones | TRBV9 = 24.8% TRBV16 = 38.9% | TRBV5.3 = 32.6% TRBV16 = 38.3% |
VB1091 | F | 46 | 35 | 1.12 | 1.61 | Polyclonal | ND | IGHV3-15 | 93.5 | No clones | TRBV18 = 37.5% | TRBV2 = 30.2% TRBV8 = 19.4% | No clones |
VB1134 | M | 58 | 34 | 2.36 | 0.46 | κ | Del13q34 (25%) | ND | ND | No clones | No clones | No clones | TRBV13.6 = 22.2% |
VB1135 | M | 62 | 35 | 0.35 | 0.35 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1170 | F | 58 | 34 | 0.85 | 0.33 | κ | ND | ND | ND | No clones | No clones | TRBV2 = 30.2% TRBV17 = 21.1% | TRBV2 = 25.0% TRBV22 = 21.7% |
VB1189 | M | 80 | 34 | 189.76 | 399.29 | κ | Normal | IGHV3-21 | 88.2 | No clones | TRBV8 = 23.1% | TRVB13.6 = 42.8% | No clones |
VB1202 | F | 61 | 34 | 4.72 | 18.56 | κ | Del13q14.3 (48%) | ND | ND | No clones | No clones | No clones | No clones |
VB1231 | F | 64 | 35 | 50.38 | 50.59 | κ | ND | IGHV3-64 | 100.0 | No clones | No clones | No clones | TRBV1 = 22.7% |
VB1239 | M | 75 | 34 | 0.41 | 0.50 | κ | ND | IGHV3-23 | 92.0 | ND | ND | ND | ND |
VB1240 | F | 84 | 31 | 1763.90 | 1249.29 | λ | Normal | IGHV3-15 | 98.3 | No clones | No clones | No clones | No clones |
VB1309 | M | 59 | 24 | 0.50 | 0.56 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1320 | F | 61 | 24 | 0.41 | 3.82 | λ | Del13q14.3-q34 (25% and 30%), Del17p (90%) | ND | ND | No clones | No clones | TRBV5.3 = 35.7% TRBV8 = 48.4% TRBV17 = 33.8% | TRBV16 = 32.1% |
VB1349 | M | 72 | 24 | 0.75 | 1.11 | κ | ND | ND | ND | No clones | TRBV1 = 61.5% | No clones | TRBV17 = 21.4% |
VB1377 | M | 68 | 24 | 3.78 | 2.42 | κ | Del13q34 (28%) | ND | ND | No clones | No clones | No clones | No clones |
VB1378 | F | 77 | 25 | 0.54 | 0.42 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1393 | F | 75 | 25 | 0.55 | 1.84 | κ | ND | ND | ND | No clones | TRBV13.2 = 25.8% | No clones | No clones |
VB1395 | F | 76 | 25 | 1.53 | 1.22 | Polyclonal | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1451 | F | 66 | 23 | 0.46 | 2.36 | κ | ND | ND | ND | No clones | No clones | TRBV2 = 45.7% | No clones |
VB1470 | F | 73 | 23 | 0.94 | 4.02 | κ | Del13q14.3† (37%) | ND | ND | No clones | TRBV13.2 = 38.3% | TRBV16 = 40.3% TRBV21.3 = 42.1% | No clones |
VB1484 | M | 64 | 24 | 0.25 | 0.73 | Polyclonal | ND | ND | ND | ND | ND | ND | ND |
VB1487 | M | 84 | 23 | 0.06 | 0.53 | κ | ND | IGHV4-59/-61 | 94.1 | No clones | No clones | No clones | TRBV7.1 = 46.4% TRBV8 = 29.4% TRBV17 = 26.9% TRBV22 = 28.6% |
VB1518 | M | 53 | 22 | 1.21 | 1.16 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1523 | M | 60 | 22 | 0.84 | 1.54 | Polyclonal | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1531 | M | 61 | 23 | 0.50 | 0.75 | Negative | ND | ND | ND | ND | ND | ND | ND |
VB1592 | F | 92 | 21 | 0.29 | 0.20 | Polyclonal | ND | IGHV3-64 | 98.1 | ND | ND | ND | ND |
VB1646 | M | 62 | 22 | 9.03 | 4.84 | Negative | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1686 | M | 83 | 22 | 0.96 | 1.31 | κ | ND | ND | ND | No clones | No clones | No clones | No clones |
VB1688 | M | 55 | 21 | 1.22 | 1.07 | Polyclonal | ND | IGHV3-21 | 95.1 | ND | ND | ND | ND |
VB1698 | M | 48 | 21 | 264.98 | 336.74 | λ | ND | IGHV3-15 | 93.0 | No clones | No clones | TRBV2 = 42.2% | TRBV17 = 42.2% |
VB1711 | F | 56 | 11 | 0.41 | 0.32 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1712 | M | 72 | 11 | 0.35 | 1.53 | κ | ND | ND | ND | ND | ND | ND | ND |
VB1736 | M | 48 | 11 | 0.68 | 0.26 | Kappa | ND | ND | ND | ND | ND | ND | ND |