Table 1

Proteins identified to be overexpressed on the SD1 plasma membrane

Accession no.NameScoreDescription
Cytoskeleton organization   
    P15153 RAC2 5 Ras-related C3 botulinum toxin substrate 2 
    P13796 LCP1 4 Plastin 2. Actin binding protein 
    P61158 ACTR3 3 Actin-related protein 3 
    Q13707 ACTA2 protein 3 Actin family 
    A7YIJ8 RDX 2 Radixin Isoform b 
    A7YIK0 RDX 2 Radixin Isoform c 
    Q4VB86 EPB41 3 Band 4.1 
    P15311 EZR 2 Ezrin 
    P26038 MSN 2 Moesin 
    P47756 CAPZB 2 F-Actin capping protein subunit 
    P59998 ARPC4 3 Actin-related protein 2/3 complex subunit 4 
    P60709 ACTB 2 β-actin 
    P68032 ACTC 3 Actin, alpha cardiac muscle 1 
    P63261 ACTG 2 Actin, cytoplasmic 2 
    P68133 ACTS 2 Actin, alpha skeletal muscle 
Migration/adhesion/invasion   
    P05362 ICAM1 5 Intercellular adhesion molecule 1 
    P33241 LSP1 5 Lymphocyte-specific protein 1 (F-actin binding protein) 
    P80723 BASP1 5 Brain acid soluble protein 1 
    P84095 RHOG 5 Rho-related GTP-binding protein RhoG 
    P27701 CD82 4 Tetraspanin-27 
    P48960 CD97 4 Leukocyte antigen CD97 
    P05107 ITGB2 3 Integrin β2 
    P19256 CD58 3 Lymphocyte function-associated antigen 3 
    P20701 ITGAL 3 Integrin αL 
    O14672 ADAM10 2 Disintegrin and metalloproteinase domain-containing protein 10 
    O60469 DSCAM 2 Down syndrome cell adhesion molecule 
    P49006 MARCKSL1 2 MARCKS-related protein 
    P55083 MFAP4 2 Microfibril-associated glycoprotein 4 
    P55285 CDH6 2 Cadherin-6 
    Q13418 ILK 2 Integrin-linked protein kinase 
Signaling   
    P16070 CD44 5 Heparan sulfate proteoglycan 
    P32970 CD70 5 Tumor necrosis factor ligand superfamily member 7 
    Q10589 BST2 5 Bone marrow stromal antigen 2 
    Q14699 RFTN1 5 Raftilin 
    P07948 LYN 4 Tyrosine-protein kinase Lyn 
    Q13291 SLAMF1 3 CD150, Signaling lymphocytic activation molecule 
    Q99808 SLC29A1 3 Equilibrative nucleoside transporter 1 
    P06239 LCK 3 Proto-oncogene tyrosine-protein kinase LCK 
    P09769 FGR 3 Proto-oncogene tyrosine-protein kinase FGR 
    P11233 RALA 3 Ras-related protein Ral-A 
    P13987 CD59 2 MEM43 antigen 
    P43250 GRK6 3 G protein-coupled receptor kinase 6 
    Q13077 TRAF1 3 TNF receptor-associated factor 1 
    Q14344 GNA13 3 Guanine nucleotide-binding protein subunit α13 
    P01111 NRAS 2 GTPase NRas 
    P01116 KRAS 2 GTPase KRas 
    P41240 CSK 2 Tyrosine-protein kinase C-SRC 
    P42892 ECE1 3 Endothelin-converting enzyme 1 
    P63244 GNBL21 2 Guanine nucleotide-binding protein subunit β2-like 1 
    Q7L7 × 3 TAO1 2 Serine/threonine-protein kinase TAO1 
    Q9HAV0 GNB4 2 Guanine nucleotide-binding protein subunit β4 
    Q96N67 DOCK7 2 Dedicator of cytokinesis protein 7 
    P54762 EPHB1 2 Ephrin type-B receptor 1 
Endocytosis   
    P02786 CD71 4 Transferrin receptor protein 1 
    P53675 CLTCL1 2 Clathrin heavy chain 2 
    Q14677 CLINT1 2 Clathrin interactor 1 
    Q15075 EEA1 2 Early endosome antigen 1 
    Q9NZN3 EHD3 2 EH domain-containing protein 3 
Vesicle formation   
    Q9H0U4 RAB1B 4 Ras-related protein Rab-1B 
    P20340 RAB6A 4 Ras-related protein Rab-6A 
    P51151 RAB9A 3 Ras-related protein Rab-9A 
    P62491 RAB11A, 3 Ras-related protein Rab-11A 
    Q15907 RAB11B 3 Ras-related protein Rab-11B 
    P51153 RAB13 3 Ras-related protein Rab-13 
    P61106 RAB14 4 Ras-related protein Rab-14 
    P59190 RAB15 3 Ras-related protein Rab-15 
    Q13277 STX3 2 Syntaxin-3 
    Q12846 STX4 2 Syntaxin-4 
    Q86Y82 STX12 4 Syntaxin-12 
    O00161 SNAP23 3 Synaptosomal-associated protein 23 
    O43760 SYNGR2 3 Synaptogyrin-2 
    O00186 STXBP3 2 Syntaxin-binding protein 3 
    P38606 ATP6V1A 3 V-type proton ATPase catalytic subunit A 
    P51809 VAMP7 3 Vesicle-associated membrane protein 7 
    Q9BV40 VAMP8 3 Vesicle-associated membrane protein 8 
    Q9NRW7 VPS45 3 Vacuolar protein sorting 45A 
Differentiation   
    P09326 CD48 5 B-lymphocyte activation marker BLAST-1 
    P11836 CD20 5 B-lymphocyte antigen CD20 
    P15814 IGLL1 2 Immunoglobulin lambda-like polypeptide 1 
    P20273 CD22 2 Sialic acid-binding Ig-like lectin 2 
Others   
    A8K0J3 Similar to TAOK3 2 Evidence at transcript level 
    A8K379 Similar To LYN 2 Evidence at transcript level 
    P06733 ENO1 3 Alpha-enolase 
    A8K6A6 Similar to MCAM 2 Evidence at transcript level 
    A8MVA9 WDR1 2 Putative uncharacterized protein WDR1 
    O60292 SIPA1L3 2 Signal-induced proliferation-associated 1-like protein 3 
    Q14168 MPP2 2 MAGUK p55 subfamily member 2 
    Q53GP0 EGF like 2 Evidence at transcript level 
    Q59GR1 Niemann-Pick disease, type C1 variant 2 Evidence at transcript level 
    Q6ICT6 TNFRSF6 2 Evidence at transcript level 
    Q8N440 NEGR1 2 Evidence at transcript level 
    Q96IH1 FSCN1 2 Evidence at transcript level 
    Q9BXV4 PNAS140 2 Evidence at transcript level 
    Q9UJM1 Putative protein 2 Evidence at transcript level 
Accession no.NameScoreDescription
Cytoskeleton organization   
    P15153 RAC2 5 Ras-related C3 botulinum toxin substrate 2 
    P13796 LCP1 4 Plastin 2. Actin binding protein 
    P61158 ACTR3 3 Actin-related protein 3 
    Q13707 ACTA2 protein 3 Actin family 
    A7YIJ8 RDX 2 Radixin Isoform b 
    A7YIK0 RDX 2 Radixin Isoform c 
    Q4VB86 EPB41 3 Band 4.1 
    P15311 EZR 2 Ezrin 
    P26038 MSN 2 Moesin 
    P47756 CAPZB 2 F-Actin capping protein subunit 
    P59998 ARPC4 3 Actin-related protein 2/3 complex subunit 4 
    P60709 ACTB 2 β-actin 
    P68032 ACTC 3 Actin, alpha cardiac muscle 1 
    P63261 ACTG 2 Actin, cytoplasmic 2 
    P68133 ACTS 2 Actin, alpha skeletal muscle 
Migration/adhesion/invasion   
    P05362 ICAM1 5 Intercellular adhesion molecule 1 
    P33241 LSP1 5 Lymphocyte-specific protein 1 (F-actin binding protein) 
    P80723 BASP1 5 Brain acid soluble protein 1 
    P84095 RHOG 5 Rho-related GTP-binding protein RhoG 
    P27701 CD82 4 Tetraspanin-27 
    P48960 CD97 4 Leukocyte antigen CD97 
    P05107 ITGB2 3 Integrin β2 
    P19256 CD58 3 Lymphocyte function-associated antigen 3 
    P20701 ITGAL 3 Integrin αL 
    O14672 ADAM10 2 Disintegrin and metalloproteinase domain-containing protein 10 
    O60469 DSCAM 2 Down syndrome cell adhesion molecule 
    P49006 MARCKSL1 2 MARCKS-related protein 
    P55083 MFAP4 2 Microfibril-associated glycoprotein 4 
    P55285 CDH6 2 Cadherin-6 
    Q13418 ILK 2 Integrin-linked protein kinase 
Signaling   
    P16070 CD44 5 Heparan sulfate proteoglycan 
    P32970 CD70 5 Tumor necrosis factor ligand superfamily member 7 
    Q10589 BST2 5 Bone marrow stromal antigen 2 
    Q14699 RFTN1 5 Raftilin 
    P07948 LYN 4 Tyrosine-protein kinase Lyn 
    Q13291 SLAMF1 3 CD150, Signaling lymphocytic activation molecule 
    Q99808 SLC29A1 3 Equilibrative nucleoside transporter 1 
    P06239 LCK 3 Proto-oncogene tyrosine-protein kinase LCK 
    P09769 FGR 3 Proto-oncogene tyrosine-protein kinase FGR 
    P11233 RALA 3 Ras-related protein Ral-A 
    P13987 CD59 2 MEM43 antigen 
    P43250 GRK6 3 G protein-coupled receptor kinase 6 
    Q13077 TRAF1 3 TNF receptor-associated factor 1 
    Q14344 GNA13 3 Guanine nucleotide-binding protein subunit α13 
    P01111 NRAS 2 GTPase NRas 
    P01116 KRAS 2 GTPase KRas 
    P41240 CSK 2 Tyrosine-protein kinase C-SRC 
    P42892 ECE1 3 Endothelin-converting enzyme 1 
    P63244 GNBL21 2 Guanine nucleotide-binding protein subunit β2-like 1 
    Q7L7 × 3 TAO1 2 Serine/threonine-protein kinase TAO1 
    Q9HAV0 GNB4 2 Guanine nucleotide-binding protein subunit β4 
    Q96N67 DOCK7 2 Dedicator of cytokinesis protein 7 
    P54762 EPHB1 2 Ephrin type-B receptor 1 
Endocytosis   
    P02786 CD71 4 Transferrin receptor protein 1 
    P53675 CLTCL1 2 Clathrin heavy chain 2 
    Q14677 CLINT1 2 Clathrin interactor 1 
    Q15075 EEA1 2 Early endosome antigen 1 
    Q9NZN3 EHD3 2 EH domain-containing protein 3 
Vesicle formation   
    Q9H0U4 RAB1B 4 Ras-related protein Rab-1B 
    P20340 RAB6A 4 Ras-related protein Rab-6A 
    P51151 RAB9A 3 Ras-related protein Rab-9A 
    P62491 RAB11A, 3 Ras-related protein Rab-11A 
    Q15907 RAB11B 3 Ras-related protein Rab-11B 
    P51153 RAB13 3 Ras-related protein Rab-13 
    P61106 RAB14 4 Ras-related protein Rab-14 
    P59190 RAB15 3 Ras-related protein Rab-15 
    Q13277 STX3 2 Syntaxin-3 
    Q12846 STX4 2 Syntaxin-4 
    Q86Y82 STX12 4 Syntaxin-12 
    O00161 SNAP23 3 Synaptosomal-associated protein 23 
    O43760 SYNGR2 3 Synaptogyrin-2 
    O00186 STXBP3 2 Syntaxin-binding protein 3 
    P38606 ATP6V1A 3 V-type proton ATPase catalytic subunit A 
    P51809 VAMP7 3 Vesicle-associated membrane protein 7 
    Q9BV40 VAMP8 3 Vesicle-associated membrane protein 8 
    Q9NRW7 VPS45 3 Vacuolar protein sorting 45A 
Differentiation   
    P09326 CD48 5 B-lymphocyte activation marker BLAST-1 
    P11836 CD20 5 B-lymphocyte antigen CD20 
    P15814 IGLL1 2 Immunoglobulin lambda-like polypeptide 1 
    P20273 CD22 2 Sialic acid-binding Ig-like lectin 2 
Others   
    A8K0J3 Similar to TAOK3 2 Evidence at transcript level 
    A8K379 Similar To LYN 2 Evidence at transcript level 
    P06733 ENO1 3 Alpha-enolase 
    A8K6A6 Similar to MCAM 2 Evidence at transcript level 
    A8MVA9 WDR1 2 Putative uncharacterized protein WDR1 
    O60292 SIPA1L3 2 Signal-induced proliferation-associated 1-like protein 3 
    Q14168 MPP2 2 MAGUK p55 subfamily member 2 
    Q53GP0 EGF like 2 Evidence at transcript level 
    Q59GR1 Niemann-Pick disease, type C1 variant 2 Evidence at transcript level 
    Q6ICT6 TNFRSF6 2 Evidence at transcript level 
    Q8N440 NEGR1 2 Evidence at transcript level 
    Q96IH1 FSCN1 2 Evidence at transcript level 
    Q9BXV4 PNAS140 2 Evidence at transcript level 
    Q9UJM1 Putative protein 2 Evidence at transcript level 

Scoring matrix is presented in the text. Proteins marked in bold have been previously identified as present in lipid rafts.50-52  Functional classification is for the purpose of this study only and proteins listed may fall into more than one category.

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