Vasoactive MC mediators
| . | Vascular permeability . | WPB exocytosis . | Chemoattraction . | Adhesion molecule up-regulation . | Angiogenesis/lymphangiogenesis . |
|---|---|---|---|---|---|
| Preformed | |||||
| Histamine | + | + | * | + | |
| Tryptase | + | + | * | Δ | Δ |
| Chymase | * | Δ | |||
| Cathepsin G | + | + | * | ||
| Serglycin-heparin proteoglycan | Δ | Δ | |||
| TNF | + | Δ | + | + | |
| IL-8 | + | + | |||
| VEGF | + | + | Δ/* | + | |
| bFGF | Δ | Δ/* | + | ||
| TGFβ | Δ | + | |||
| Eicosanoids | |||||
| LTB4 | + | ||||
| LTC4 | + | + | |||
| LTD4 | + | + | |||
| LTE4 | + | + | |||
| PGD2 | Δ/* | * | |||
| PAF | + | + | + | + | |
| Selected de novo cytokines | |||||
| TNF | + | + | + | ||
| IL-1 | Δ/* | + | + | ||
| IL-6 | Δ | Δ | + | ||
| GM-CSF | * | ||||
| CCL1 | + | ||||
| MCP1 (CCL2) | + | Δ | /* | ||
| MIP1α (CCL3) | + | Δ/* | |||
| MIP1β (CCL4) | + | ||||
| MIP2 (CXCL2) | + | Δ |
| . | Vascular permeability . | WPB exocytosis . | Chemoattraction . | Adhesion molecule up-regulation . | Angiogenesis/lymphangiogenesis . |
|---|---|---|---|---|---|
| Preformed | |||||
| Histamine | + | + | * | + | |
| Tryptase | + | + | * | Δ | Δ |
| Chymase | * | Δ | |||
| Cathepsin G | + | + | * | ||
| Serglycin-heparin proteoglycan | Δ | Δ | |||
| TNF | + | Δ | + | + | |
| IL-8 | + | + | |||
| VEGF | + | + | Δ/* | + | |
| bFGF | Δ | Δ/* | + | ||
| TGFβ | Δ | + | |||
| Eicosanoids | |||||
| LTB4 | + | ||||
| LTC4 | + | + | |||
| LTD4 | + | + | |||
| LTE4 | + | + | |||
| PGD2 | Δ/* | * | |||
| PAF | + | + | + | + | |
| Selected de novo cytokines | |||||
| TNF | + | + | + | ||
| IL-1 | Δ/* | + | + | ||
| IL-6 | Δ | Δ | + | ||
| GM-CSF | * | ||||
| CCL1 | + | ||||
| MCP1 (CCL2) | + | Δ | /* | ||
| MIP1α (CCL3) | + | Δ/* | |||
| MIP1β (CCL4) | + | ||||
| MIP2 (CXCL2) | + | Δ |
+ indicates clear evidence for a direct role in this process; Δ, possible role/limited or conflicting evidence; and *, potentiates the effect of another mediator.