Table 3

RRs with 95% CIs for associations of sun sensitivity or exposure with risk of CLL/SLL, MM, and HL

Sun sensitivity or exposureChronic lymphocytic leukemia/small lymphocytic lymphoma
Multiple myeloma
Pheterogeneity by lymphoma subtype†Hodgkin lymphoma
Cases (n)RR (95% CI)*Cases (n)RR (95% CI)*Cases (n)RR (95% CI)*
Skin reaction to hot sun exposure for 1 hour without protection        
    Severe burn with blistering 15 1.00 (reference) 17 1.00 (reference)  13 1.00 (reference) 
    Severe burn without blistering 24 1.21 (0.63-2.30) 17 0.75 (0.38-1.46)    
    Mild burn, then tan or darken 56 1.25 (0.71-2.22) 51 0.99 (0.57-1.71)  22 0.86 (0.43-1.70) 
    No burn 25 1.13 (0.59-2.14) 28 1.08 (0.59-1.98) .55   
Skin reaction to repeated sun exposure        
    Deep tan or darkening 30 1.00 (reference) 29 1.00 (reference)  24 1.00 (reference) 
    Moderate tan or darkening 50 0.78 (0.50-1.23) 41 0.67 (0.42-1.08)    
    Light or no tan or darkening 36 0.73 (0.45-1.18) 42 0.90 (0.56-1.45) .78 11 0.99 (0.48-2.02) 
Age at first blistering sunburn, y        
    Never 38 1.00 (reference) 45 1.00 (reference)  12 1.00 (reference) 
    ≤ 10 18 1.11 (0.63-1.96) 13 0.67 (0.36-1.24)  13 0.93 (0.42-2.04) 
    11-15 25 1.02 (0.61-1.69) 21 0.73 (0.43-1.23)    
    16-20 21 1.04 (0.61-1.77) 18 0.77 (0.44-1.33)  11 1.16 (0.51-2.63) 
    ≥ 21 17 1.36 (0.77-2.42) 16 1.11 (0.63-1.97) .67   
Number of times with blistering sunburn        
    Never 38 1.00 (reference) 45 1.00 (reference)  12 1.00 (reference) 
    1-2 33 0.99 (0.62-1.58) 34 0.87 (0.56-1.36)  13 1.25 (0.57-2.74) 
    3-4 27 1.32 (0.81-2.17) 14 0.59 (0.32-1.07)  11 0.87 (0.38-1.97) 
    ≥ 5 19 1.05 (0.60-1.83) 18 0.85 (0.49-1.47) .25   
History of melanoma or other skin cancer        
    No 102 1.00 (reference) 105 1.00 (reference)  35 1.00 (reference) 
    Yes 23 1.18 (0.75-1.85) 14 0.70 (0.40-1.22) .07 3 0.68 (0.21-2.27) 
Sun sensitivity or exposureChronic lymphocytic leukemia/small lymphocytic lymphoma
Multiple myeloma
Pheterogeneity by lymphoma subtype†Hodgkin lymphoma
Cases (n)RR (95% CI)*Cases (n)RR (95% CI)*Cases (n)RR (95% CI)*
Skin reaction to hot sun exposure for 1 hour without protection        
    Severe burn with blistering 15 1.00 (reference) 17 1.00 (reference)  13 1.00 (reference) 
    Severe burn without blistering 24 1.21 (0.63-2.30) 17 0.75 (0.38-1.46)    
    Mild burn, then tan or darken 56 1.25 (0.71-2.22) 51 0.99 (0.57-1.71)  22 0.86 (0.43-1.70) 
    No burn 25 1.13 (0.59-2.14) 28 1.08 (0.59-1.98) .55   
Skin reaction to repeated sun exposure        
    Deep tan or darkening 30 1.00 (reference) 29 1.00 (reference)  24 1.00 (reference) 
    Moderate tan or darkening 50 0.78 (0.50-1.23) 41 0.67 (0.42-1.08)    
    Light or no tan or darkening 36 0.73 (0.45-1.18) 42 0.90 (0.56-1.45) .78 11 0.99 (0.48-2.02) 
Age at first blistering sunburn, y        
    Never 38 1.00 (reference) 45 1.00 (reference)  12 1.00 (reference) 
    ≤ 10 18 1.11 (0.63-1.96) 13 0.67 (0.36-1.24)  13 0.93 (0.42-2.04) 
    11-15 25 1.02 (0.61-1.69) 21 0.73 (0.43-1.23)    
    16-20 21 1.04 (0.61-1.77) 18 0.77 (0.44-1.33)  11 1.16 (0.51-2.63) 
    ≥ 21 17 1.36 (0.77-2.42) 16 1.11 (0.63-1.97) .67   
Number of times with blistering sunburn        
    Never 38 1.00 (reference) 45 1.00 (reference)  12 1.00 (reference) 
    1-2 33 0.99 (0.62-1.58) 34 0.87 (0.56-1.36)  13 1.25 (0.57-2.74) 
    3-4 27 1.32 (0.81-2.17) 14 0.59 (0.32-1.07)  11 0.87 (0.38-1.97) 
    ≥ 5 19 1.05 (0.60-1.83) 18 0.85 (0.49-1.47) .25   
History of melanoma or other skin cancer        
    No 102 1.00 (reference) 105 1.00 (reference)  35 1.00 (reference) 
    Yes 23 1.18 (0.75-1.85) 14 0.70 (0.40-1.22) .07 3 0.68 (0.21-2.27) 
*

All models adjusted for age (as timescale) and calendar-year effects.

†

Lymphoma subtypes include diffuse large B-cell lymphoma, follicular lymphoma, CLL/SLL, and MM.

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