Clinical characteristics of 1185 AML patients
| Characteristics . | AML without prognostic cytogenetic markers (group I)* . | CBF leukemias (group II) . | APL (AML-M3; group III) . |
|---|---|---|---|
| Sex, no. of the patients (%) | |||
| Male | 348 (29.4) | 104 (8.8) | 199 (16.8) |
| Female | 257 (21.7) | 72 (6.1) | 189 (15.9) |
| Mean age, y | 43.2 ± 18.9 | 31.4 ± 19.5 | 34.7 ± 17.1 |
| Range | 18-86 | 18-75 | 18-80 |
| No. of the patients aged < 60† | 481 | 160 | 354 |
| Median WBC count, × 109/L (range) | 13.35 (0.5-453) | 10.05 (0.8-177.9) | 2.9 (0.3-205.7) |
| Median BM blasts, % (range) | 69 (22.5-97) | 60 (23.5-91) | 64 (22.5-91.0) |
| FAB subtype, no. of the patients (%) | |||
| M0 | 10 (0.8) | ||
| M1 | 33 (2.8) | ||
| M2a | 120 (10.1) | ||
| M2b | 124 (10.5) | ||
| M3 | 388 (32.7) | ||
| M4 | 188 (15.9) | 25 (2.1) | |
| M4eo | 18 (1.5) | ||
| M5 | 200 (16.9) | 5 (0.4) | |
| M6 | 23 (1.9) | ||
| M7 | 2 (0.2) | ||
| Not classified | 29 (2.4) | 4 (3.4) |
| Characteristics . | AML without prognostic cytogenetic markers (group I)* . | CBF leukemias (group II) . | APL (AML-M3; group III) . |
|---|---|---|---|
| Sex, no. of the patients (%) | |||
| Male | 348 (29.4) | 104 (8.8) | 199 (16.8) |
| Female | 257 (21.7) | 72 (6.1) | 189 (15.9) |
| Mean age, y | 43.2 ± 18.9 | 31.4 ± 19.5 | 34.7 ± 17.1 |
| Range | 18-86 | 18-75 | 18-80 |
| No. of the patients aged < 60† | 481 | 160 | 354 |
| Median WBC count, × 109/L (range) | 13.35 (0.5-453) | 10.05 (0.8-177.9) | 2.9 (0.3-205.7) |
| Median BM blasts, % (range) | 69 (22.5-97) | 60 (23.5-91) | 64 (22.5-91.0) |
| FAB subtype, no. of the patients (%) | |||
| M0 | 10 (0.8) | ||
| M1 | 33 (2.8) | ||
| M2a | 120 (10.1) | ||
| M2b | 124 (10.5) | ||
| M3 | 388 (32.7) | ||
| M4 | 188 (15.9) | 25 (2.1) | |
| M4eo | 18 (1.5) | ||
| M5 | 200 (16.9) | 5 (0.4) | |
| M6 | 23 (1.9) | ||
| M7 | 2 (0.2) | ||
| Not classified | 29 (2.4) | 4 (3.4) |
In addition to groups I, II, and III, there was a small group of 16 cases with relatively rare prognostic cytogenetic markers (see text).
Not classified refers to the AML patients without typical morphological characteristics and could not be defined by FAB classification.
WBC indicates white blood cell; BM, bone marrow; and no., number
Except for those with 11q23 (see text).
These patients were treated intensively in group I and II (see text).