Table 1 Hyperphosphorylation of... | American Society of Hematology

Table 1

Hyperphosphorylation of autoantigenic paraprotein targets

Paratarg no.	Antigen	Type of antigen	No. of binding	Subtype*	Phosphorylation state
1	Cylicin 2	Allaontigen†	1/115 nonfamilial cases	1 × IgA-λ	No data available
2	TPP2	Autoantigen‡	1/115 nonfamilial cases	1 × IgG-κ	Hyperphosphorylated
3	IGFBP-2	Autoantigen‡	1/115 nonfamilial cases	1 × IgG-κ	No data available
4	Porcine kinesin	Heteroantigen	1/115 nonfamilial cases	1 × IgG-κ	No data available
5	Microtubule-associated protein	Autoantigen‡	2/103 nonfamilial cases	1 × IgM-κ, 1 × IgG-λ	Hyperphosphorylated
6	LAPTM5	Autoantigen‡	3/103 nonfamilial cases	2 × IgG-λ, 1 × IgG-κ	Hyperphosphorylated
7	SLP-2	Autoantigen‡	4 cases from 2 families; 76/650 nonfamilial cases	See Grass et al²	Hyperphosphorylated
8	ATG13	Autoantigen‡	4 cases from 1 family; 1/300 nonfamilial cases	3 × IgG-λ, 1 × IgG-κ	Hyperphosphorylated
9	RSP16	Autoantigen‡	1/300 nonfamilial cases	1 × IgG-κ	Hyperphosphorylated
10	SPAG7	Autoantigen‡	2/300 nonfamilial cases	2 × IgG-λ	Hyperphosphorylated
11	SIVA	Autoantigen‡	2/300 nonfamilial cases	1 × IgG-κ, 1 × IgA-λ	Hyperphosphorylated

Paratarg no.	Antigen	Type of antigen	No. of binding	Subtype*	Phosphorylation state
1	Cylicin 2	Allaontigen†	1/115 nonfamilial cases	1 × IgA-λ	No data available
2	TPP2	Autoantigen‡	1/115 nonfamilial cases	1 × IgG-κ	Hyperphosphorylated
3	IGFBP-2	Autoantigen‡	1/115 nonfamilial cases	1 × IgG-κ	No data available
4	Porcine kinesin	Heteroantigen	1/115 nonfamilial cases	1 × IgG-κ	No data available
5	Microtubule-associated protein	Autoantigen‡	2/103 nonfamilial cases	1 × IgM-κ, 1 × IgG-λ	Hyperphosphorylated
6	LAPTM5	Autoantigen‡	3/103 nonfamilial cases	2 × IgG-λ, 1 × IgG-κ	Hyperphosphorylated
7	SLP-2	Autoantigen‡	4 cases from 2 families; 76/650 nonfamilial cases	See Grass et al²	Hyperphosphorylated
8	ATG13	Autoantigen‡	4 cases from 1 family; 1/300 nonfamilial cases	3 × IgG-λ, 1 × IgG-κ	Hyperphosphorylated
9	RSP16	Autoantigen‡	1/300 nonfamilial cases	1 × IgG-κ	Hyperphosphorylated
10	SPAG7	Autoantigen‡	2/300 nonfamilial cases	2 × IgG-λ	Hyperphosphorylated
11	SIVA	Autoantigen‡	2/300 nonfamilial cases	1 × IgG-κ, 1 × IgA-λ	Hyperphosphorylated

The number of paraproteins with the respective specificity among all paraproteins tested for this specificity.

Cylicin 2 is sperm-specific; hence, it functioned as an alloantigen in the respective female patient.

Autoantigen, because it is expressed in the autologous patient's tissues.