Biological processes significantly enriched in down-regulated gene transcripts in Nrf2−/− mice
| . | P . | No. of molecules . |
|---|---|---|
| Top physiological system development and function | ||
| Hematological system development and function | 1.53 × 10−24 to 3.61 × 10−06 | 39 |
| Immune-cell trafficking | 1.53 × 10−24 to 3.61 × 10−06 | 34 |
| Cell-mediated immune response | 2.35 × 10−24 to 2.541 × 10−06 | 44 |
| Humoral immune response | 2.35 × 10−23 to 1.52 × 10−06 | 43 |
| Hematopoiesis | 1.8 × 10−18 to 9.31 × 10−07 | 28 |
| Top molecular and cellular function | ||
| Cell-to-cell signaling and interaction | 2.55 × 10−28 to 3.61 × 10−06 | 41 |
| Cellular development | 4.92 × 10−28 to 2.88 × 10−06 | 40 |
| Ag presentation | 2.35 × 10−23 to 2.17 × 10−06 | 43 |
| Cellular movement | 4.44 × 10−19 to 3.55 × 10−06 | 32 |
| Cell death | 3.05 × 10−18 to 3.41 × 10−06 | 44 |
| . | P . | No. of molecules . |
|---|---|---|
| Top physiological system development and function | ||
| Hematological system development and function | 1.53 × 10−24 to 3.61 × 10−06 | 39 |
| Immune-cell trafficking | 1.53 × 10−24 to 3.61 × 10−06 | 34 |
| Cell-mediated immune response | 2.35 × 10−24 to 2.541 × 10−06 | 44 |
| Humoral immune response | 2.35 × 10−23 to 1.52 × 10−06 | 43 |
| Hematopoiesis | 1.8 × 10−18 to 9.31 × 10−07 | 28 |
| Top molecular and cellular function | ||
| Cell-to-cell signaling and interaction | 2.55 × 10−28 to 3.61 × 10−06 | 41 |
| Cellular development | 4.92 × 10−28 to 2.88 × 10−06 | 40 |
| Ag presentation | 2.35 × 10−23 to 2.17 × 10−06 | 43 |
| Cellular movement | 4.44 × 10−19 to 3.55 × 10−06 | 32 |
| Cell death | 3.05 × 10−18 to 3.41 × 10−06 | 44 |
Data were analyzed using Ingenuity Pathways (Igenuity Systems, www.ingenuity.com). The P value associated with a biological process or pathway annotation is a measure of its statistical significance with respect to the Functions/Pathways/Lists Eligible molecules for the dataset and a Reference Set of molecules (which define the molecules that could possibly have been Functions/Pathways/Lists/Eligible). The P values were calculated with the right-tailed Fisher exact test.