ASE activity distributions (< 50 U/L and > 50 U/L) with different ASE preparations compared against E coli ASE, at different Ab levels. Results were generated applying a generalized linear model that was fitted by generalized estimating equations (GEE)
| ASE . | Ab level* . | OR (activity >50 U/L) . | Confidence limits . | P (χ2) . | Statistically significant difference in therapy? . |
|---|---|---|---|---|---|
| ASE activity comparison between native and pegylated E coli ASE at different Ab levels | |||||
| Native E coli vs pegylated E coli | Ab− | 1.08 | 0.28-4.25 | .9074 | No, both therapies are comparably effective, native is insignificantly better than pegylated E coli ASE |
| Pegylated E coli vs native E coli | Ab+ | 15.62 | 1.82-134.07 | .0122 | Yes, pegylated is superior to native E coli ASE by OR |
| Pegylated E coli vs native E coli | Ab++ | 8.97 | 2.74-29.34 | .0003 | Yes, pegylated is superior to native E coli ASE by OR |
| Pegylated E coli vs native E coli | Ab+++ | 3.24 | 0.36-29.34 | .295 | No, both therapies are comparably ineffective, pegylated is insignificantly better than native E coli ASE |
| ASE activity comparison between native E coli and Erwinia ASE at different Ab levels | |||||
| Native E coli vs Erwinia | Ab− | 4.02 | 1.37-11.82 | .0114 | Yes, native E coli is superior to Erwinia ASE by OR |
| Erwinia vs native E coli | Ab+ | 5.17 | 0.84-31.78 | .0762 | Borderline yes, Erwinia is superior to native E coli ASE by OR |
| Erwinia vs native E coli | Ab++ | 8.15 | 2.37-28.03 | .0009 | Yes, Erwinia is superior to native E coli ASE by OR |
| Erwinia vs native E coli | Ab+++ | 34.90 | 3.76-323.75 | .0018 | Yes, Erwinia is superior to native E coli ASE by OR |
| ASE activity comparison between pegylated E coli and Erwinia ASE at different Ab levels | |||||
| Pegylated E coli vs Erwinia | Ab− | 3.71 | 0.95-14.49 | .0593 | Borderline yes, pegylated E coli ASE is superior to Erwinia ASE by OR |
| Pegylated E coli vs Erwinia | Ab+ | 3.02 | 0.42-21.87 | .2736 | No, both therapies are comparably effective, pegylated E coli ASE is insignificantly better than Erwinia ASE |
| Pegylated E coli vs Erwinia | Ab++ | 1.10 | 0.54-2.23 | .7884 | No, both therapies are comparably effective, pegylated E coli ASE is insignificantly better than Erwinia ASE |
| Erwinia vs pegylated E coli | Ab+++ | 10.76 | 5.94-19.49 | <.0001 | Yes, Erwinia ASE is superior to pegylated E coli ASE by OR |
| ASE . | Ab level* . | OR (activity >50 U/L) . | Confidence limits . | P (χ2) . | Statistically significant difference in therapy? . |
|---|---|---|---|---|---|
| ASE activity comparison between native and pegylated E coli ASE at different Ab levels | |||||
| Native E coli vs pegylated E coli | Ab− | 1.08 | 0.28-4.25 | .9074 | No, both therapies are comparably effective, native is insignificantly better than pegylated E coli ASE |
| Pegylated E coli vs native E coli | Ab+ | 15.62 | 1.82-134.07 | .0122 | Yes, pegylated is superior to native E coli ASE by OR |
| Pegylated E coli vs native E coli | Ab++ | 8.97 | 2.74-29.34 | .0003 | Yes, pegylated is superior to native E coli ASE by OR |
| Pegylated E coli vs native E coli | Ab+++ | 3.24 | 0.36-29.34 | .295 | No, both therapies are comparably ineffective, pegylated is insignificantly better than native E coli ASE |
| ASE activity comparison between native E coli and Erwinia ASE at different Ab levels | |||||
| Native E coli vs Erwinia | Ab− | 4.02 | 1.37-11.82 | .0114 | Yes, native E coli is superior to Erwinia ASE by OR |
| Erwinia vs native E coli | Ab+ | 5.17 | 0.84-31.78 | .0762 | Borderline yes, Erwinia is superior to native E coli ASE by OR |
| Erwinia vs native E coli | Ab++ | 8.15 | 2.37-28.03 | .0009 | Yes, Erwinia is superior to native E coli ASE by OR |
| Erwinia vs native E coli | Ab+++ | 34.90 | 3.76-323.75 | .0018 | Yes, Erwinia is superior to native E coli ASE by OR |
| ASE activity comparison between pegylated E coli and Erwinia ASE at different Ab levels | |||||
| Pegylated E coli vs Erwinia | Ab− | 3.71 | 0.95-14.49 | .0593 | Borderline yes, pegylated E coli ASE is superior to Erwinia ASE by OR |
| Pegylated E coli vs Erwinia | Ab+ | 3.02 | 0.42-21.87 | .2736 | No, both therapies are comparably effective, pegylated E coli ASE is insignificantly better than Erwinia ASE |
| Pegylated E coli vs Erwinia | Ab++ | 1.10 | 0.54-2.23 | .7884 | No, both therapies are comparably effective, pegylated E coli ASE is insignificantly better than Erwinia ASE |
| Erwinia vs pegylated E coli | Ab+++ | 10.76 | 5.94-19.49 | <.0001 | Yes, Erwinia ASE is superior to pegylated E coli ASE by OR |
Results were generated applying a generalized linear model that was fitted by generalized estimating equations.
ASE indicates antileukemic enzyme asparaginase; and OR, odds ratio.
Ab−: < 6.25 AU/mL; Ab+: 6.25-20 AU/mL; Ab++: 20-200 AU/mL; Ab+++: > 200 AU/mL.